PMID- 29536218
OWN - NLM
STAT- MEDLINE
DCOM- 20181102
LR  - 20181114
IS  - 1568-5608 (Electronic)
IS  - 0925-4692 (Linking)
VI  - 26
IP  - 4
DP  - 2018 Aug
TI  - Pharmacological mechanisms underlying gastroprotective activities of binapthyl 
      diselenide in Wistar rats.
PG  - 1117-1123
LID - 10.1007/s10787-018-0451-7 [doi]
AB  - Selenium (Se) is a dietary essential trace element with important biological 
      roles. It is a nutrient related to the complex metabolic and enzymatic functions. 
      Organoselenium compounds have been reported to have anti-ulcer activity and used 
      as drug for the treatment of gastrointestinal disorders. The antiulcer activity 
      of binapthyl diselenide (NapSe)2 was investigated in ethanol-induced gastric 
      lesions in rats. A number of markers of oxidative stress were examined in rats 
      stomach including thiobarbituric acid reactive species (TBARS), catalase (CAT), 
      superoxide dismutase (SOD), non-protein thiol groups (NPSH) and ascorbic acid. 
      (NapSe)2 was found to be significantly restoring the deficits in the antioxidant 
      defense mechanisms (CAT, SOD, NPSH and ascorbic acid), and suppressed lipid 
      peroxidation in rat stomach resulting from EtOH administration. It is 
      experimentally concluded that ethanol exposure causes alterations in the 
      antioxidant defense system and induces oxidative stress in rat stomach. These 
      studies establish a promising foundation for investigating and understanding the 
      beneficial effects of organoselenium compounds on human health. Moreover, 
      (NaPSe)(2) deserves further investigation as a therapeutic and preventive agent 
      against gastric ulcer in humans.
FAU - Ibrahim, Mohammad
AU  - Ibrahim M
AD  - Programa de Pos-Graduacao em Ciencias Biologicas- Bioquimica Toxicologica, Centro 
      de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, 
      RS, CEP 97105-900, Brazil. dribrahim@awkum.edu.pk.
AD  - Department of Chemistry, Abdul Wali Khan University Mardan (AWKUM) KPK, Mardan, 
      Pakistan. dribrahim@awkum.edu.pk.
FAU - Ibrahim, Musadiq
AU  - Ibrahim M
AD  - Department of Chemistry and Division of Biochemistry and Life Science, University 
      of Glasgow, Glasgow, G128QQ, UK.
AD  - Department of Chemistry, Kohat University of Science and Technology, Kohat, 
      Khyber Pakhtun Khwa, Pakistan.
FAU - Muhammad, Niaz
AU  - Muhammad N
AD  - Programa de Pos-Graduacao em Ciencias Biologicas- Bioquimica Toxicologica, Centro 
      de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, 
      RS, CEP 97105-900, Brazil.
FAU - Shah, Muhammad Ishaq Ali
AU  - Shah MIA
AD  - Department of Chemistry, Abdul Wali Khan University Mardan (AWKUM) KPK, Mardan, 
      Pakistan.
FAU - de Oliveira Leite, Gerlania
AU  - de Oliveira Leite G
AD  - Programa de Pos-Graduacao em Ciencias Biologicas- Bioquimica Toxicologica, Centro 
      de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, 
      RS, CEP 97105-900, Brazil.
FAU - Rocha, Joao B T
AU  - Rocha JBT
AD  - Programa de Pos-Graduacao em Ciencias Biologicas- Bioquimica Toxicologica, Centro 
      de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, 
      RS, CEP 97105-900, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20180313
PL  - Switzerland
TA  - Inflammopharmacology
JT  - Inflammopharmacology
JID - 9112626
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Organoselenium Compounds)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 0 (binaphthyl diselenide)
RN  - 3K9958V90M (Ethanol)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Animals
MH  - Anti-Ulcer Agents/*pharmacology
MH  - Antioxidants/metabolism
MH  - Catalase/metabolism
MH  - Disease Models, Animal
MH  - Ethanol/toxicity
MH  - Lipid Peroxidation/drug effects
MH  - Male
MH  - Organoselenium Compounds/*pharmacology
MH  - Oxidative Stress/*drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Stomach Ulcer/*prevention & control
MH  - Superoxide Dismutase/metabolism
MH  - Thiobarbituric Acid Reactive Substances/metabolism
OTO - NOTNLM
OT  - Anti-ulcer activity
OT  - Lipid peroxidation
OT  - SOD
OT  - Selenium: Oxidative stress: TBARS: CAT
EDAT- 2018/03/15 06:00
MHDA- 2018/11/06 06:00
CRDT- 2018/03/15 06:00
PHST- 2017/10/02 00:00 [received]
PHST- 2018/02/01 00:00 [accepted]
PHST- 2018/03/15 06:00 [pubmed]
PHST- 2018/11/06 06:00 [medline]
PHST- 2018/03/15 06:00 [entrez]
AID - 10.1007/s10787-018-0451-7 [pii]
AID - 10.1007/s10787-018-0451-7 [doi]
PST - ppublish
SO  - Inflammopharmacology. 2018 Aug;26(4):1117-1123. doi: 10.1007/s10787-018-0451-7. 
      Epub 2018 Mar 13.