PMID- 29536614
OWN - NLM
STAT- MEDLINE
DCOM- 20180924
LR  - 20180924
IS  - 1097-0231 (Electronic)
IS  - 0951-4198 (Linking)
VI  - 32
IP  - 11
DP  - 2018 Jun 15
TI  - Low-temperature plasma-probe mass spectrometry based method for determination of 
      new psychoactive substances in oral fluid.
PG  - 913-918
LID - 10.1002/rcm.8112 [doi]
AB  - RATIONALE: Owing to the widespread abuse of new psychoactive substances (NPSs), 
      developing a rapid, easily operable method to detect NPSs in oral fluid is of 
      high priority. Their ease of collection and non-invasive nature make oral fluid 
      samples suitable for on-site tests and forensic cases. Herein we report a rapid 
      and sensitive method to screen and quantitate 11 new NPSs in oral fluid. METHODS: 
      Low-temperature plasma-probe mass spectrometry (LTP-MS) was applied and, to 
      improve the signal intensity, thermally assisted desorption was employed. Tandem 
      mass spectrometry was performed to exclude false positive signals and to decrease 
      noise at the m/z values of interest. RESULTS: Linearity was studied using 
      matrix-matched calibration curves; all the analytes exhibited good linearity with 
      R(2) varying from 0.9907 to 0.9981. The estimated limits of detection (LODs) were 
      in the range of 3.0-15.2 ng/mL, which are comparable to those of immunoassay; 
      relative standard deviations (RSDs) are no greater than 23% at the studied 
      concentration levels. CONCLUSIONS: The proposed LTP-MS-based method was promising 
      in forensic and on-site applications to curb the abuse of NPSs.
CI  - Copyright (c) 2018 John Wiley & Sons, Ltd.
FAU - Wang, Xiaochen
AU  - Wang X
AUID- ORCID: 0000-0001-8931-0846
AD  - College of Chemistry and Molecular Engineering, Peking University, Beijing, 
      100871, China.
AD  - Center for Environment and Water Resources, College of Chemistry and Chemical 
      Engineering, Central South University, Changsha, 410083, China.
FAU - Hua, Zhendong
AU  - Hua Z
AD  - National Narcotics Laboratory, Drug Intelligence and Forensic Center of the 
      Ministry of Public Security, Beijing, 100193, China.
FAU - Yang, Zhaoguang
AU  - Yang Z
AD  - Center for Environment and Water Resources, College of Chemistry and Chemical 
      Engineering, Central South University, Changsha, 410083, China.
FAU - Li, Haipu
AU  - Li H
AD  - Center for Environment and Water Resources, College of Chemistry and Chemical 
      Engineering, Central South University, Changsha, 410083, China.
FAU - Liu, Huwei
AU  - Liu H
AD  - College of Chemistry and Molecular Engineering, Peking University, Beijing, 
      100871, China.
FAU - Qiu, Bo
AU  - Qiu B
AD  - Center for Environment and Water Resources, College of Chemistry and Chemical 
      Engineering, Central South University, Changsha, 410083, China.
FAU - Nie, Honggang
AU  - Nie H
AD  - College of Chemistry and Molecular Engineering, Peking University, Beijing, 
      100871, China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Rapid Commun Mass Spectrom
JT  - Rapid communications in mass spectrometry : RCM
JID - 8802365
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Humans
MH  - Limit of Detection
MH  - Psychotropic Drugs/*analysis
MH  - Reproducibility of Results
MH  - Saliva/*chemistry
MH  - Tandem Mass Spectrometry/instrumentation/*methods
MH  - Temperature
EDAT- 2018/03/15 06:00
MHDA- 2018/09/25 06:00
CRDT- 2018/03/15 06:00
PHST- 2017/12/22 00:00 [received]
PHST- 2018/03/06 00:00 [revised]
PHST- 2018/03/09 00:00 [accepted]
PHST- 2018/03/15 06:00 [pubmed]
PHST- 2018/09/25 06:00 [medline]
PHST- 2018/03/15 06:00 [entrez]
AID - 10.1002/rcm.8112 [doi]
PST - ppublish
SO  - Rapid Commun Mass Spectrom. 2018 Jun 15;32(11):913-918. doi: 10.1002/rcm.8112.