PMID- 29536615 OWN - NLM STAT- MEDLINE DCOM- 20181217 LR - 20211204 IS - 1613-4133 (Electronic) IS - 1613-4125 (Linking) VI - 62 IP - 10 DP - 2018 May TI - Plasma ANGPTL-4 is Associated with Obesity and Glucose Tolerance: Cross-Sectional and Longitudinal Findings. PG - e1800060 LID - 10.1002/mnfr.201800060 [doi] AB - SCOPE: Angiopoietin-like protein 4 (ANGPTL-4) regulates plasma lipoprotein levels, but its relevance in human obesity and type 2 diabetes (T2D) is largely unknown. We aim to investigate the regulation of circulating ANGPTL-4 levels in obesity, T2D, and after changes in body weight. METHODS AND RESULTS: Circulating ANGPTL-4 levels were measured in two different cohorts. First, in a cross-sectional study, we evaluated ANGPTL-4 levels in lean and obese patients with normoglycemia or with altered glucose tolerance (AGT; n = 282). Second, in a longitudinal intervention study, 51 obese participants were evaluated. A hypocaloric diet was prescribed, with follow-up 2 years later. ANGPTL-4 levels were significantly increased in obese patients with AGT compared to lean participants. Moreover, ANGPTL-4 was positively correlated with BMI, waist circumference, fat mass, HbA1c, HOMA-IR, fasting triglycerides, and with inflammatory markers. Participants gaining weight after the follow-up showed increased ANGPTL-4 levels in parallel to increased BMI, fat mass, and fasting glucose, while ANGPTL-4 levels were reduced in participants losing weight. CONCLUSION: Our data support a relevant role of ANGPTL-4 in human obesity and its involvement in long-term body weight changes. CI - (c) 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. FAU - Barja-Fernandez, Silvia AU - Barja-Fernandez S AD - Grupo Fisiopatologia Endocrina, IDIS, Complejo Hospitalario Universitario de Santiago de Compostela, Spain. AD - Departamento de Pediatria, Universidad de Santiago de Compostela, Spain. AD - CIBER Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Spain. FAU - Moreno-Navarrete, Jose Maria AU - Moreno-Navarrete JM AD - CIBER Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Spain. AD - Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigacio Biomedica de Girona Hospital Dr. Josep Trueta, Girona, Spain. FAU - Folgueira, Cintia AU - Folgueira C AD - Grupo Fisiopatologia Endocrina, IDIS, Complejo Hospitalario Universitario de Santiago de Compostela, Spain. AD - CIBER Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Spain. AD - Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigacion Sanitaria, Santiago de Compostela, 15782, Spain. FAU - Xifra, Gemma AU - Xifra G AD - CIBER Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Spain. AD - Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigacio Biomedica de Girona Hospital Dr. Josep Trueta, Girona, Spain. FAU - Sabater, Monica AU - Sabater M AD - CIBER Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Spain. AD - Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigacio Biomedica de Girona Hospital Dr. Josep Trueta, Girona, Spain. FAU - Castelao, Cecilia AU - Castelao C AD - Grupo Fisiopatologia Endocrina, IDIS, Complejo Hospitalario Universitario de Santiago de Compostela, Spain. AD - CIBER Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Spain. FAU - FernO, Johan AU - FernO J AD - KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway. FAU - Leis, Rosaura AU - Leis R AD - Departamento de Pediatria, Universidad de Santiago de Compostela, Spain. AD - CIBER Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Spain. FAU - Dieguez, Carlos AU - Dieguez C AD - CIBER Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Spain. AD - Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigacion Sanitaria, Santiago de Compostela, 15782, Spain. FAU - Casanueva, Felipe F AU - Casanueva FF AD - CIBER Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Spain. AD - Departamento de Medicina, Universidad de Santiago de Compostela, Spain. FAU - Ricart, Wifredo AU - Ricart W AD - CIBER Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Spain. AD - Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigacio Biomedica de Girona Hospital Dr. Josep Trueta, Girona, Spain. FAU - Seoane, Luisa M AU - Seoane LM AD - Grupo Fisiopatologia Endocrina, IDIS, Complejo Hospitalario Universitario de Santiago de Compostela, Spain. AD - CIBER Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Spain. FAU - Fernandez-Real, Jose Manuel AU - Fernandez-Real JM AD - CIBER Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Spain. AD - Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigacio Biomedica de Girona Hospital Dr. Josep Trueta, Girona, Spain. FAU - Nogueiras, Ruben AU - Nogueiras R AD - CIBER Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Spain. AD - Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigacion Sanitaria, Santiago de Compostela, 15782, Spain. LA - eng PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20180430 PL - Germany TA - Mol Nutr Food Res JT - Molecular nutrition & food research JID - 101231818 RN - 0 (ANGPTL4 protein, human) RN - 0 (Angiopoietin-Like Protein 4) SB - IM MH - Adult MH - Angiopoietin-Like Protein 4/*blood MH - Body Weight MH - Cross-Sectional Studies MH - Diabetes Mellitus, Type 2/*blood MH - Female MH - Glucose Intolerance MH - Humans MH - Longitudinal Studies MH - Male MH - Middle Aged MH - Obesity/*blood/diet therapy MH - Waist Circumference MH - Weight Loss OTO - NOTNLM OT - ANGPTL-4 OT - BMI OT - glucose intolerance OT - obesity OT - weight changes EDAT- 2018/03/15 06:00 MHDA- 2018/12/18 06:00 CRDT- 2018/03/15 06:00 PHST- 2018/01/16 00:00 [received] PHST- 2018/02/14 00:00 [revised] PHST- 2018/03/15 06:00 [pubmed] PHST- 2018/12/18 06:00 [medline] PHST- 2018/03/15 06:00 [entrez] AID - 10.1002/mnfr.201800060 [doi] PST - ppublish SO - Mol Nutr Food Res. 2018 May;62(10):e1800060. doi: 10.1002/mnfr.201800060. Epub 2018 Apr 30.