PMID- 29536637
OWN - NLM
STAT- MEDLINE
DCOM- 20181113
LR  - 20181113
IS  - 1865-1682 (Electronic)
IS  - 1865-1674 (Linking)
VI  - 65
IP  - 5
DP  - 2018 Oct
TI  - A modified-live porcine reproductive and respiratory syndrome virus (PRRSV)-1 
      vaccine protects late-term pregnancy gilts against heterologous PRRSV-1 but not 
      PRRSV-2 challenge.
PG  - 1227-1234
LID - 10.1111/tbed.12862 [doi]
AB  - The objective of this study was to determine the efficacy of a commercially 
      available porcine reproductive and respiratory syndrome virus (PRRSV)-1 
      modified-live virus (MLV) vaccine against PRRSV-1 and PRRSV-2 challenge in 
      late-term pregnancy gilts. Gilts were vaccinated with the PRRSV-1 MLV vaccine at 
      4 weeks prior to breeding and then challenged intranasally with PRRSV-1 or 
      PRRSV-2 at 93 days of gestation. After PRRSV-1 challenge, vaccinated pregnant 
      gilts had a significantly longer gestation period, significantly higher numbers 
      of live-born and weaned piglets and a significantly lower number of stillborn 
      piglets at birth compared to unvaccinated pregnant gilts. No significant 
      improvement in reproductive performance was observed between vaccinated and 
      unvaccinated pregnant gilts following PRRSV-2 challenge. Vaccinated pregnant 
      gilts also exhibited a significantly improved reproductive performance after 
      challenge with PRRSV-1 compared to vaccinated pregnant gilts following PRRSV-2 
      challenge. The PRRSV-1 MLV vaccine was able to reduce PRRSV-1 but not PRRSV-2 
      viremia in pregnant gilts. Vaccinated gilts also showed a significantly higher 
      number of PRRSV-1-specific IFN-gamma-secreting cells (IFN-gamma-SC) compared to 
      PRRSV-2-specific IFN-gamma-SC. The data presented here suggest that the vaccination 
      of pregnant gilts with a PRRSV-1 MLV vaccine provides good protection against 
      PRRSV-1 but only limited protection against PRRSV-2 challenge in late-term 
      pregnancy gilts based on improvement of reproductive performance, reduction in 
      viremia and induction of IFN-gamma-SC.
CI  - (c) 2018 Blackwell Verlag GmbH.
FAU - Jeong, J
AU  - Jeong J
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Korea.
FAU - Kang, I
AU  - Kang I
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Korea.
FAU - Kim, S
AU  - Kim S
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Korea.
FAU - Park, S-J
AU  - Park SJ
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Korea.
FAU - Park, K H
AU  - Park KH
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Korea.
FAU - Oh, T
AU  - Oh T
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Korea.
FAU - Yang, S
AU  - Yang S
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Korea.
FAU - Chae, C
AU  - Chae C
AUID- ORCID: 0000-0002-0190-1957
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Korea.
LA  - eng
SI  - GENBANK/JN315686
SI  - GENBANK/JN315685
GR  - Research Institute for Veterinary Science/
GR  - College of Veterinary Medicine/
GR  - 5260-20150100/BK 21 Plus Program/
PT  - Journal Article
DEP - 20180313
PL  - Germany
TA  - Transbound Emerg Dis
JT  - Transboundary and emerging diseases
JID - 101319538
RN  - 0 (Antibodies, Viral)
RN  - 0 (Vaccines, Live, Unattenuated)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Administration, Intranasal
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - Female
MH  - Porcine Reproductive and Respiratory Syndrome/*prevention & control
MH  - Porcine respiratory and reproductive syndrome virus/*immunology
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/prevention & control/*veterinary
MH  - Reproduction
MH  - Stillbirth
MH  - Swine
MH  - Vaccination/*veterinary
MH  - Vaccines, Live, Unattenuated/immunology
MH  - Viral Vaccines/*administration & dosage/immunology
MH  - Viremia/immunology
OTO - NOTNLM
OT  - modified-live virus vaccine
OT  - porcine reproductive and respiratory syndrome virus
OT  - reproductive failure
OT  - sow
OT  - vaccine
EDAT- 2018/03/15 06:00
MHDA- 2018/11/14 06:00
CRDT- 2018/03/15 06:00
PHST- 2017/09/22 00:00 [received]
PHST- 2018/03/15 06:00 [pubmed]
PHST- 2018/11/14 06:00 [medline]
PHST- 2018/03/15 06:00 [entrez]
AID - 10.1111/tbed.12862 [doi]
PST - ppublish
SO  - Transbound Emerg Dis. 2018 Oct;65(5):1227-1234. doi: 10.1111/tbed.12862. Epub 
      2018 Mar 13.