PMID- 2953691
OWN - NLM
STAT- MEDLINE
DCOM- 19870626
LR  - 20191029
IS  - 0172-4622 (Print)
IS  - 0172-4622 (Linking)
VI  - 8 Suppl 1
DP  - 1987 Mar
TI  - Enzymatic adaptations consequent to long-term strength training.
PG  - 66-9
AB  - The muscle enzymatic changes subsequent to 6 months of strength training followed 
      by 3 months of detraining were examined in 21 physically active men. They were 
      assigned either to a heavy-resistance (HR) or an explosive strength (EX) training 
      program. Muscle biopsies were obtained from m. vastus lateralis for the 
      assessment of activities of the enzymes hexokinase (HK), myofibrillar ATPase 
      (ATPase), citrate synthase (CS), phosphofructokinase (PFK), lactate dehydrogenase 
      (LDH), myokinase (MK) and creatine kinase (CK). The activities were measured on 
      freeze-dried tissue samples using fluorometrical assays. Both groups displayed 
      increased (P less than 0.01-0.001) fast-twitch (FT) fiber area consequent to 
      training with no concomitant hypertrophy of slow-twitch (ST) fiber area. Mean 
      fiber area increased by 16% (P less than 0.001) in HR and 9% (NS) in EX. 
      Following detraining, mean fiber area returned to pretraining value only in EX. 
      HK decreased in both groups (P less than 0.01-0.001) and CK decreased in HR (P 
      less than 0.05). When the two groups were treated together, all enzymes, except 
      for LDH, decreased their activity (P less than 0.05-0.001). It is concluded that 
      6 months of strength training performed either as heavy-resistance or explosive 
      training is not associated with any increased activities of enzymes reflecting 
      phosphagen, glycolytic, or oxidative metabolism. Instead, the present results 
      suggest that exercise-induced hypertrophy is accompanied by attenuation of 
      certain enzyme activities of importance for ATP regeneration.
FAU - Tesch, P A
AU  - Tesch PA
FAU - Komi, P V
AU  - Komi PV
FAU - Hakkinen, K
AU  - Hakkinen K
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Int J Sports Med
JT  - International journal of sports medicine
JID - 8008349
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 2.3.3.1 (Citrate (si)-Synthase)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 2.7.1.11 (Phosphofructokinase-1)
RN  - EC 2.7.3.2 (Creatine Kinase)
RN  - EC 2.7.4.3 (Adenylate Kinase)
RN  - EC 3.6.1.- (Adenosine Triphosphatases)
SB  - IM
MH  - Adenosine Triphosphatases/metabolism
MH  - Adenylate Kinase/metabolism
MH  - Adult
MH  - Body Constitution
MH  - Citrate (si)-Synthase/metabolism
MH  - Creatine Kinase/metabolism
MH  - Hexokinase/metabolism
MH  - Histocytochemistry
MH  - Humans
MH  - L-Lactate Dehydrogenase/metabolism
MH  - Male
MH  - Muscles/anatomy & histology/*enzymology
MH  - Phosphofructokinase-1/metabolism
MH  - *Physical Education and Training
EDAT- 1987/03/01 00:00
MHDA- 1987/03/01 00:01
CRDT- 1987/03/01 00:00
PHST- 1987/03/01 00:00 [pubmed]
PHST- 1987/03/01 00:01 [medline]
PHST- 1987/03/01 00:00 [entrez]
AID - 10.1055/s-2008-1025706 [doi]
PST - ppublish
SO  - Int J Sports Med. 1987 Mar;8 Suppl 1:66-9. doi: 10.1055/s-2008-1025706.