PMID- 29537221
OWN - NLM
STAT- MEDLINE
DCOM- 20180329
LR  - 20191113
IS  - 2522-9028 (Print)
IS  - 2522-9028 (Linking)
VI  - 62
IP  - 2
DP  - 2016
TI  - EXCITABILITY PROPERTIES OF TRIGEMINAL GANGLION NEURONS.
PG  - 24-34
AB  - The firing properties of small neurons (with diameters of soma less than 25 microm) 
      were investigated using patch-clamp technique in whole-cell configuration in 
      primary culture of trigeminal ganglia (TG) of postnatal rats. TG neurons were 
      divided into three groups according to their firing responses to long-lasting 
      depolarizing pulses: adaptive neurons (AN) characterized by a strongly adaptive 
      responses; tonic neurons (TN) characterized by a multiple tonic firing; neurons 
      with a delay before initiation of AP generation, namely, NDG. AN, TN and NDG also 
      differed in AP electrophysiological and pharmacological characteristics. TN was 
      distinguished by responses to hyperpolarization and the greatest value of input 
      resistance. TN, AN and NDG were characterized by different active properties 
      (amplitude of action potential and afterhyperpolarization, reobase, threshold). 
      Each group of neurons was characterized by heterogeneity of AP duration and of 
      frequency properties for TN. The application of tetrodotoxin (TTX) (250 nM) 
      resulted in full or partial inhibition of AP generation and some neurons had TTX 
      - insensitive firing responses. Neurons that were not affected by TTX had 
      markedly longer AP. TTX had no effect on electrical activity of some AN and NDG. 
      Based on sensitivity to TTX and their electrophysiological properties, AN and NDG 
      seem to be C-fiber nococeptors.
FAU - Telka, M V
AU  - Telka MV
FAU - Rikhalsky, O V
AU  - Rikhalsky OV
FAU - Veselovsky, N S
AU  - Veselovsky NS
LA  - eng
PT  - Journal Article
PL  - Ukraine
TA  - Fiziol Zh (1994)
JT  - Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)
JID - 9601541
RN  - 0 (Sodium Channel Blockers)
RN  - 0 (Sodium Channels)
RN  - 4368-28-9 (Tetrodotoxin)
SB  - IM
MH  - Action Potentials/drug effects/*physiology
MH  - Animals
MH  - Animals, Newborn
MH  - Female
MH  - Male
MH  - Neurons/*classification/cytology/drug effects/*physiology
MH  - Patch-Clamp Techniques
MH  - Primary Cell Culture
MH  - Rats
MH  - Rats, Wistar
MH  - Sodium Channel Blockers/pharmacology
MH  - Sodium Channels/metabolism
MH  - Tetrodotoxin/pharmacology
MH  - Time Factors
MH  - Trigeminal Ganglion/cytology/drug effects/*physiology
EDAT- 2016/01/01 00:00
MHDA- 2018/03/30 06:00
CRDT- 2018/03/15 06:00
PHST- 2018/03/15 06:00 [entrez]
PHST- 2016/01/01 00:00 [pubmed]
PHST- 2018/03/30 06:00 [medline]
AID - 10.15407/fz62.02.024 [doi]
PST - ppublish
SO  - Fiziol Zh (1994). 2016;62(2):24-34. doi: 10.15407/fz62.02.024.