PMID- 29537920
OWN - NLM
STAT- MEDLINE
DCOM- 20190716
LR  - 20190716
IS  - 1522-1598 (Electronic)
IS  - 0022-3077 (Print)
IS  - 0022-3077 (Linking)
VI  - 120
IP  - 1
DP  - 2018 Jul 1
TI  - Sherlock Holmes and the curious case of the human locomotor central pattern 
      generator.
PG  - 53-77
LID - 10.1152/jn.00554.2017 [doi]
AB  - Evidence first described in reduced animal models over 100 years ago led to 
      deductions about the control of locomotion through spinal locomotor central 
      pattern-generating (CPG) networks. These discoveries in nature were 
      contemporaneous with another form of deductive reasoning found in popular 
      culture, that of Arthur Conan Doyle's detective, Sherlock Holmes. Because the 
      invasive methods used in reduced nonhuman animal preparations are not amenable to 
      study in humans, we are left instead with deducing from other measures and 
      observations. Using the deductive reasoning approach of Sherlock Holmes as a 
      metaphor for framing research into human CPGs, we speculate and weigh the 
      evidence that should be observable in humans based on knowledge from other 
      species. This review summarizes indirect inference to assess "observable 
      evidence" of pattern-generating activity that leads to the logical deduction of 
      CPG contributions to arm and leg activity during locomotion in humans. The 
      question of where a CPG may be housed in the human nervous system remains 
      incompletely resolved at this time. Ongoing understanding, elaboration, and 
      application of functioning locomotor CPGs in humans is important for gait 
      rehabilitation strategies in those with neurological injuries.
FAU - Klarner, Taryn
AU  - Klarner T
AD  - Rehabilitation Neuroscience Laboratory, University of Victoria , Victoria, 
      British Columbia , Canada.
AD  - Human Discovery Science, International Collaboration on Repair Discoveries , 
      Vancouver, British Columbia , Canada.
AD  - Centre for Biomedical Research, University of Victoria , Victoria, British 
      Columbia , Canada.
FAU - Zehr, E Paul
AU  - Zehr EP
AD  - Rehabilitation Neuroscience Laboratory, University of Victoria , Victoria, 
      British Columbia , Canada.
AD  - Human Discovery Science, International Collaboration on Repair Discoveries , 
      Vancouver, British Columbia , Canada.
AD  - Centre for Biomedical Research, University of Victoria , Victoria, British 
      Columbia , Canada.
AD  - Division of Medical Sciences, University of Victoria, British Columbia, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180314
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
SB  - IM
MH  - Animals
MH  - Central Pattern Generators/*physiology
MH  - Humans
MH  - *Locomotion
PMC - PMC6093959
EDAT- 2018/03/15 06:00
MHDA- 2019/07/17 06:00
PMCR- 2019/07/01
CRDT- 2018/03/15 06:00
PHST- 2018/03/15 06:00 [pubmed]
PHST- 2019/07/17 06:00 [medline]
PHST- 2018/03/15 06:00 [entrez]
PHST- 2019/07/01 00:00 [pmc-release]
AID - JN-00554-2017 [pii]
AID - 10.1152/jn.00554.2017 [doi]
PST - ppublish
SO  - J Neurophysiol. 2018 Jul 1;120(1):53-77. doi: 10.1152/jn.00554.2017. Epub 2018 
      Mar 14.