PMID- 29537940
OWN - NLM
STAT- MEDLINE
DCOM- 20200417
LR  - 20200417
IS  - 2045-7723 (Electronic)
IS  - 1079-0268 (Print)
IS  - 1079-0268 (Linking)
VI  - 42
IP  - 1
DP  - 2019 Jan
TI  - Epidural stimulation with locomotor training improves body composition in 
      individuals with cervical or upper thoracic motor complete spinal cord injury: A 
      series of case studies.
PG  - 32-38
LID - 10.1080/10790268.2018.1449373 [doi]
AB  - CONTEXT: Four individuals with motor complete SCI with an implanted epidural 
      stimulator who were enrolled in another study were assessed for cardiovascular 
      fitness, metabolic function and body composition at four time points before, 
      during, and after task specific training. Following 80 locomotor training 
      sessions, a 16-electrode array was surgically placed on the dura (L1-S1 cord 
      segments) to allow for electrical stimulation. After implantation individuals 
      received 160 sessions of task specific training with epidural stimulation (stand 
      and step). OUTCOME MEASURES: Dual-energy X-ray absorptiometry (DXA), resting 
      metabolic rate and peak oxygen consumption (VO(2)peak) were measured before 
      locomotor training, after locomotor training but before epidural stimulator 
      implant, at mid-locomotor training with spinal cord epidural stimulation (scES) 
      and after locomotor training with scES. FINDINGS: Participants showed increases 
      in lean body mass with decreases on percentage of body fat, particularly android 
      body fat, and android/gynoid ratio from baseline to post training; resting 
      metabolic rate and VO(2)peak also show increases that are of clinical relevance 
      in this population. CONCLUSIONS: Task specific training combined with epidural 
      stimulation has the potential to show improvements in cardiovascular fitness and 
      body composition in individuals with cervical or upper thoracic motor complete 
      SCI.
FAU - Terson de Paleville, Daniela G L
AU  - Terson de Paleville DGL
AD  - a Department of Health and Sport Sciences, Exercise Physiology , University of 
      Louisville , Louisville , Kentucky.
FAU - Harkema, Susan J
AU  - Harkema SJ
AD  - b Kentucky Spinal Cord Injury Center , University of Louisville , Louisville , 
      Kentucky.
AD  - c Department of Neurological Surgery , University of Louisville , Louisville , 
      Kentucky.
AD  - d Human Locomotion Research Center, Frazier Rehab Institute , Louisville , 
      Kentucky.
FAU - Angeli, Claudia A
AU  - Angeli CA
AD  - b Kentucky Spinal Cord Injury Center , University of Louisville , Louisville , 
      Kentucky.
AD  - d Human Locomotion Research Center, Frazier Rehab Institute , Louisville , 
      Kentucky.
LA  - eng
GR  - R01 EB007615/EB/NIBIB NIH HHS/United States
GR  - P30 GM103507/GM/NIGMS NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20180314
PL  - England
TA  - J Spinal Cord Med
JT  - The journal of spinal cord medicine
JID - 9504452
SB  - IM
MH  - Adult
MH  - *Body Composition
MH  - Cervical Vertebrae/injuries
MH  - Epidural Space/physiopathology
MH  - Exercise Therapy/*methods
MH  - Humans
MH  - *Locomotion
MH  - Male
MH  - Oxygen Consumption
MH  - Spinal Cord Injuries/*rehabilitation
MH  - Spinal Cord Stimulation/*methods
MH  - Thoracic Vertebrae/injuries
PMC - PMC6340278
OTO - NOTNLM
OT  - Body composition
OT  - Cardiovascular fitness
OT  - Epidural stimulation with locomotor training
EDAT- 2018/03/15 06:00
MHDA- 2020/04/18 06:00
PMCR- 2020/01/01
CRDT- 2018/03/15 06:00
PHST- 2018/03/15 06:00 [pubmed]
PHST- 2020/04/18 06:00 [medline]
PHST- 2018/03/15 06:00 [entrez]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 1449373 [pii]
AID - 10.1080/10790268.2018.1449373 [doi]
PST - ppublish
SO  - J Spinal Cord Med. 2019 Jan;42(1):32-38. doi: 10.1080/10790268.2018.1449373. Epub 
      2018 Mar 14.