PMID- 29539155
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1943-3670 (Electronic)
IS  - 0022-3492 (Linking)
VI  - 78
IP  - 7
DP  - 2007 Jul
TI  - Effect of 17beta-Estradiol and Alendronate on the Removal Torque of Osseointegrated 
      Titanium Implants in Ovariectomized Rats.
PG  - 1316-1321
LID - 10.1902/jop.2007.060390 [doi]
AB  - BACKGROUND: This study investigated the influence of estrogen deficiency and its 
      treatment with estrogen and alendronate on the removal torque of osseointegrated 
      titanium implants. METHODS: Fifty-eight female Wistar rats received a titanium 
      implant in the tibia metaphysis. After 60 days, which was needed for implant 
      osseointegration, the animals were randomly divided into five groups: control 
      (CTLE; N = 10), sham surgery (SHAM; N = 12), ovariectomy (OVX; N = 12), 
      ovariectomy followed by hormone replacement (EST; N = 12), and ovariectomy 
      followed by treatment with alendronate (ALE; N = 12). The CTLE group was 
      sacrificed to confirm osseointegration, whereas the remaining groups were 
      submitted to sham surgery or ovariectomy according to their designations. After 
      90 days, these animals were also sacrificed. Densitometry of femur and lumbar 
      vertebrae was performed by dual-energy x-ray absorptiometry (DXA) to confirm 
      systemic impairment of the animals. All implants were subjected to removal 
      torque. RESULTS: Densitometric analysis of the femur and lumbar vertebrae 
      confirmed a systemic impairment of the animals, disclosing lower values of bone 
      mineral density for OVX. Analysis of the removal torque of the implants showed 
      statistically lower values (P <0.05) for the OVX group in relation to the other 
      groups. However, the group treated with alendronate (ALE group) presented 
      significantly higher torque values compared to the others. CONCLUSION: According 
      to this study, estrogen deficiency was observed to have a negative influence on 
      the removal torque of osseointegrated implants, whereas treatment with 
      alendronate increased the torque needed to remove the implants.
CI  - (c) 2007 American Academy of Periodontology.
FAU - Giro, Gabriela
AU  - Giro G
AD  - Department of Oral Diagnosis and Surgery, School of Dentistry of Araraquara, 
      State University of Sao Paulo, Araraquara, SP, Brazil.
FAU - Sakakura, Celso Eduardo
AU  - Sakakura CE
AD  - Department of Oral Diagnosis and Surgery, School of Dentistry of Araraquara, 
      State University of Sao Paulo, Araraquara, SP, Brazil.
FAU - Goncalves, Daniela
AU  - Goncalves D
AD  - Department of Oral Diagnosis and Surgery, School of Dentistry of Araraquara, 
      State University of Sao Paulo, Araraquara, SP, Brazil.
FAU - Pereira, Rosa M R
AU  - Pereira RMR
AD  - Department of Rheumatology, School of Medicine, University of Sao Paulo, Sao 
      Paulo, SP, Brazil.
FAU - Marcantonio, Elcio Jr
AU  - Marcantonio E Jr
AD  - Department of Oral Diagnosis and Surgery, School of Dentistry of Araraquara, 
      State University of Sao Paulo, Araraquara, SP, Brazil.
FAU - Orrico, Silvana R P
AU  - Orrico SRP
AD  - Department of Oral Diagnosis and Surgery, School of Dentistry of Araraquara, 
      State University of Sao Paulo, Araraquara, SP, Brazil.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
OTO - NOTNLM
OT  - Alendronate
OT  - dental implants
OT  - estrogen replacement therapy
OT  - osteoporosis
OT  - ovariectomy
OT  - rats
EDAT- 2007/07/01 00:00
MHDA- 2007/07/01 00:01
CRDT- 2018/03/15 06:00
PHST- 2006/10/02 00:00 [received]
PHST- 2007/01/28 00:00 [accepted]
PHST- 2018/03/15 06:00 [entrez]
PHST- 2007/07/01 00:00 [pubmed]
PHST- 2007/07/01 00:01 [medline]
AID - 10.1902/jop.2007.060390 [doi]
PST - ppublish
SO  - J Periodontol. 2007 Jul;78(7):1316-1321. doi: 10.1902/jop.2007.060390.