PMID- 29539236
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1943-3670 (Electronic)
IS  - 0022-3492 (Linking)
VI  - 79
IP  - 11
DP  - 2008 Nov
TI  - The Short-Term Effectiveness of Non-Surgical Treatment in Reducing Levels of 
      Interleukin-1beta and Proteases in Gingival Crevicular Fluid From Patients With Type 
      2 Diabetes Mellitus and Chronic Periodontitis.
PG  - 2143-2150
LID - 10.1902/jop.2008.080132 [doi]
AB  - BACKGROUND: This study aimed to compare the effectiveness of non-surgical 
      periodontal treatment in improving periodontal status and reducing gingival 
      crevicular fluid (GCF) levels of interleukin (IL)-1beta and IL-18, elastase 
      activity, and matrix metalloproteinase (MMP)--8 and --9 in periodontitis patients 
      with and without type 2 diabetes mellitus (T2DM). METHODS: Twenty-three patients 
      with T2DM (diabetes group) and 26 systemically healthy subjects (control group) 
      with chronic periodontitis participated in this study. The clinical examination 
      included visible plaque index, gingival bleeding index, probing depth, clinical 
      attachment level, and bleeding on probing. GCF samples were collected from five 
      or six deep sites to evaluate the levels of IL-1beta and -18, elastase, and MMP-8 
      and -9. Shallow sites were analyzed for IL-1beta and elastase. The glycemic control 
      was analyzed by the concentration of glycated hemoglobin (HbA1c). The subjects 
      received non-surgical periodontal treatment and were reexamined 90 days later. 
      RESULTS: All clinical parameters showed a significant improvement after 
      treatment, which was accompanied by a significant reduction in IL-1beta, elastase 
      activity, and MMP-8 and -9 levels in deep sites. The shallow sites also showed 
      significant reductions in IL-1beta and elastase activity levels. Treatment did not 
      significantly reduce HbA1c concentrations in patients with T2DM. CONCLUSIONS: 
      Non-surgical periodontal treatment was effective in reducing the levels of IL-1beta, 
      elastase activity, and MMP-8 and -9 in GCF from diabetes and control groups. 
      Patients with T2DM showed less reduction only in elastase activity in shallow 
      sites compared to controls. This reduction was associated with improvement of the 
      clinical periodontal status.
CI  - (c) 2008 American Academy of Periodontology.
FAU - Correa, Fernanda O B
AU  - Correa FOB
AD  - Department of Diagnosis and Surgery, School of Dentistry, Sao Paulo State 
      University, Araraquara, SP, Brazil.
AD  - Division of Periodontology, Institute of Odontology, Karolinska Institute, 
      Stockholm, Sweden.
FAU - Goncalves, Daniela
AU  - Goncalves D
AD  - Department of Diagnosis and Surgery, School of Dentistry, Sao Paulo State 
      University, Araraquara, SP, Brazil.
FAU - Figueredo, Carlos M S
AU  - Figueredo CMS
AD  - Division of Periodontology, Institute of Odontology, Karolinska Institute, 
      Stockholm, Sweden.
AD  - Department of Periodontology, School of Dentistry, Rio de Janeiro State 
      University, Rio de Janeiro, RJ, Brazil.
FAU - Gustafsson, Anders
AU  - Gustafsson A
AD  - Division of Periodontology, Institute of Odontology, Karolinska Institute, 
      Stockholm, Sweden.
FAU - Orrico, Silvana R P
AU  - Orrico SRP
AD  - Department of Diagnosis and Surgery, School of Dentistry, Sao Paulo State 
      University, Araraquara, SP, Brazil.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
OTO - NOTNLM
OT  - Clinical trial
OT  - cytokines
OT  - diabetes mellitus, type 2
OT  - gingival crevicular fluid
OT  - matrix metalloproteinases
EDAT- 2008/11/01 00:00
MHDA- 2008/11/01 00:01
CRDT- 2018/03/15 06:00
PHST- 2008/03/07 00:00 [received]
PHST- 2008/05/30 00:00 [accepted]
PHST- 2018/03/15 06:00 [entrez]
PHST- 2008/11/01 00:00 [pubmed]
PHST- 2008/11/01 00:01 [medline]
AID - 10.1902/jop.2008.080132 [doi]
PST - ppublish
SO  - J Periodontol. 2008 Nov;79(11):2143-2150. doi: 10.1902/jop.2008.080132.