PMID- 29539998
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2194-802X (Electronic)
IS  - 2194-802X (Linking)
VI  - 1
IP  - 3
DP  - 2014 Sep 1
TI  - Framingham Risk Score for the prediction of coronary artery disease in patients 
      with chronic rheumatic heart disease.
PG  - 233-238
LID - /j/dx.2014.1.issue-3/dx-2014-0010/dx-2014-0010.xml [pii]
LID - 10.1515/dx-2014-0010 [doi]
AB  - BACKGROUND: Patients with chronic rheumatic heart disease (CRHD) have concomitant 
      coronary artery disease (CAD), but the model to detect coexistent coronary artery 
      stenosis prior to surgery has not been validated. Our study investigated whether 
      the Framingham Risk Score (FRS) is a valid predictor of CAD in patients 
      undergoing surgery for CRHD. METHODS: A total of 989 rheumatic patients were 
      enrolled between 2005 and 2010. They were subdivided into two groups according to 
      coronary angiography (CAG) results to identify potential factors in the 
      development of CAD. Finally, all patients were assessed using the FRS to examine 
      the association between the 10-year cardiovascular disease (CVD) risk and CAD. 
      RESULTS: There were statistically significant inter-group differences in terms of 
      age, sex, smoking, hypertension, bypass surgery and cardiac function in the New 
      York Heart Association (NYHA) classification status (p<0.05). We showed that the 
      FRS had high accuracy in predicting CAD in female and male patients with CRHD. In 
      the male group, the area under the curve (AUC) for predicting CAD was 0.904, with 
      a specificity of 90.3% and sensitivity of 76.1%. In the female group, the AUC for 
      predicting CAD was 0.924, with a specificity of 77.5% and sensitivity of 90.9%, 
      respectively. With a cut-off point of a 10-year CVD risk of 12.5 (%) in the male 
      group and a 10-year CVD risk of 2.5 (%) in the female group, the FRS identified 
      746 low-risk patients, including 11 (4.3%) with CAD in the male group and 4 
      (0.8%) with CAD in the female group. None of the patients needed an indication 
      for coronary artery bypass grafting (CABG). CONCLUSIONS: The FRS model can 
      accurately predict the prevalence of significant CAD and can reliably identify 
      low-risk patients in whom routine pre-surgical angiography could be avoided.
FAU - Lin, Yaowang
AU  - Lin Y
AD  - 1Department of Cardiology, Southern Medical University Affiliated Guangdong 
      General Hospital (Guangdong Academy of Medical Sciences), Guangzhou, P.R. China.
FAU - Wei, Xuebiao
AU  - Wei X
AD  - 1Department of Cardiology, Southern Medical University Affiliated Guangdong 
      General Hospital (Guangdong Academy of Medical Sciences), Guangzhou, P.R. China.
FAU - Cai, Anping
AU  - Cai A
AD  - 2Department of Cardiology, Guangdong General Hospital (Guangdong Academy of 
      Medical Sciences), Guangzhou, P.R. China.
FAU - Yang, Xing
AU  - Yang X
AD  - 2Department of Cardiology, Guangdong General Hospital (Guangdong Academy of 
      Medical Sciences), Guangzhou, P.R. China.
FAU - Zhou, Yingling
AU  - Zhou Y
AD  - 2Department of Cardiology, Guangdong General Hospital (Guangdong Academy of 
      Medical Sciences), Guangzhou, P.R. China.
FAU - Yu, Danqing
AU  - Yu D
AD  - 2Department of Cardiology, Guangdong General Hospital (Guangdong Academy of 
      Medical Sciences), Guangzhou, P.R. China.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Diagnosis (Berl)
JT  - Diagnosis (Berlin, Germany)
JID - 101654734
OTO - NOTNLM
OT  - Framingham Risk Score
OT  - chronic rheumatic heart disease
OT  - coronary artery disease
EDAT- 2014/09/01 00:00
MHDA- 2014/09/01 00:01
CRDT- 2018/03/16 06:00
PHST- 2014/02/15 00:00 [received]
PHST- 2014/05/15 00:00 [accepted]
PHST- 2018/03/16 06:00 [entrez]
PHST- 2014/09/01 00:00 [pubmed]
PHST- 2014/09/01 00:01 [medline]
AID - /j/dx.2014.1.issue-3/dx-2014-0010/dx-2014-0010.xml [pii]
AID - 10.1515/dx-2014-0010 [doi]
PST - ppublish
SO  - Diagnosis (Berl). 2014 Sep 1;1(3):233-238. doi: 10.1515/dx-2014-0010.