PMID- 29540242 OWN - NLM STAT- MEDLINE DCOM- 20180910 LR - 20181114 IS - 1756-0500 (Electronic) IS - 1756-0500 (Linking) VI - 11 IP - 1 DP - 2018 Mar 14 TI - Comparison of single nucleotide polymorphisms in the 3' untranslated region of HLA-G in placentas between spontaneous preterm birth and preeclampsia. PG - 176 LID - 10.1186/s13104-018-3280-2 [doi] LID - 176 AB - OBJECTIVE: To compare single nucleotide polymorphisms (SNPs) in the 3'-untranslated region (3'UTR) of human leukocyte antigen (HLA)-G in placentas between spontaneous preterm birth and preeclampsia pregnancies. RESULTS: Placental samples matched for gestational age were obtained from 20 cases of spontaneous preterm births and 19 cases of preeclampsia. Genomic deoxyribonucleic acid was extracted from placenta tissue and the 3'UTR region of HLA-G was amplified via polymerase chain reaction. Nine SNPs were analyzed by direct Sanger sequencing. There was no significant difference in gestational age at delivery or birth weight between two groups. And there were no significant differences in the allele and phenotype frequencies between two groups. FAU - Lee, Ji Young AU - Lee JY AD - Department of Obstetrics and Gynecology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, 130 Dongdeok-ro, Jung-gu, Daegu, 700-721, South Korea. FAU - Kim, Hyun Mi AU - Kim HM AD - Department of Obstetrics and Gynecology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, 130 Dongdeok-ro, Jung-gu, Daegu, 700-721, South Korea. FAU - Kim, Mi Ju AU - Kim MJ AD - Department of Obstetrics and Gynecology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, 130 Dongdeok-ro, Jung-gu, Daegu, 700-721, South Korea. FAU - Cha, Hyun-Hwa AU - Cha HH AD - Department of Obstetrics and Gynecology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, 130 Dongdeok-ro, Jung-gu, Daegu, 700-721, South Korea. chh9861@knu.ac.kr. FAU - Seong, Won Joon AU - Seong WJ AD - Department of Obstetrics and Gynecology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, 130 Dongdeok-ro, Jung-gu, Daegu, 700-721, South Korea. LA - eng PT - Comparative Study PT - Journal Article DEP - 20180314 PL - England TA - BMC Res Notes JT - BMC research notes JID - 101462768 RN - 0 (3' Untranslated Regions) RN - 0 (HLA-G Antigens) SB - IM MH - 3' Untranslated Regions/*genetics MH - Adult MH - Female MH - HLA-G Antigens/*genetics MH - Humans MH - Placenta/*metabolism MH - Polymorphism, Single Nucleotide MH - Pre-Eclampsia/*genetics MH - Pregnancy MH - Premature Birth/*genetics PMC - PMC5853103 OTO - NOTNLM OT - HLA-G OT - Placenta OT - Preeclampsia OT - Preterm births OT - Single nucleotide polymorphism EDAT- 2018/03/16 06:00 MHDA- 2018/09/11 06:00 PMCR- 2018/03/14 CRDT- 2018/03/16 06:00 PHST- 2017/12/27 00:00 [received] PHST- 2018/03/07 00:00 [accepted] PHST- 2018/03/16 06:00 [entrez] PHST- 2018/03/16 06:00 [pubmed] PHST- 2018/09/11 06:00 [medline] PHST- 2018/03/14 00:00 [pmc-release] AID - 10.1186/s13104-018-3280-2 [pii] AID - 3280 [pii] AID - 10.1186/s13104-018-3280-2 [doi] PST - epublish SO - BMC Res Notes. 2018 Mar 14;11(1):176. doi: 10.1186/s13104-018-3280-2.