PMID- 29540625
OWN - NLM
STAT- MEDLINE
DCOM- 20180702
LR  - 20211204
IS  - 1347-5223 (Electronic)
IS  - 0009-2363 (Linking)
VI  - 66
IP  - 6
DP  - 2018 Jun 1
TI  - Dietary Exposure Risk Assessment of Flonicamid and Its Effect on Constituents 
      after Application in Lonicerae Japonicae Flos.
PG  - 608-611
LID - 10.1248/cpb.c17-00985 [doi]
AB  - To investigate the dietary exposure risk of flonicamid application on Lonicerae 
      Japonicae Flos and the effect of flonicamid on constituents of Lonicerae 
      Japonicae Flos, field experiments were conducted in Fengqiu, Henan province, and 
      flonicamid residue in samples collected was detected by gas chromatography 
      equipped with electron capture detector (GC-ECD). And chlorogenic acid and 
      luteoloside were determined by HPLC. Dietary exposure risk assessment was 
      conducted through comparing the estimated daily intake (EDI) which was calculated 
      by using the consumed residual level along with the acceptable daily intake 
      (ADI). The effect of flonicamid on chlorogenic acid and luteoloside were obtained 
      by ANOVA statistical analysis and least significant difference (LSD)-t test. The 
      results showed that the terminal-residue contents of flonicamid were under 1.6 mg 
      kg(-1). And risk quotient ranged from 0.0011 to 0.0028, indicating the long-term 
      exposure to flonicamid residual through consumption of Lonicerae Japonicae Flos 
      in consumers was relatively low. Flonicamid could suppress the generation of 
      luteoloside, so it was not advised to be used in L. japonica flowering phase. The 
      study aims at providing the useful suggestion on the reasonable flonicamid usage 
      and the reference for the establishment of maximum residue limits (MRLs) of 
      flonicamid in Lonicerae Japonicae Flos.
FAU - Li, Jiaxin
AU  - Li J
AD  - Institute of Medicinal Plant Development, Chinese Academy of Medical Science & 
      Peking Union Medical College.
FAU - Wang, Yujie
AU  - Wang Y
AD  - Institute of Medicinal Plant Development, Chinese Academy of Medical Science & 
      Peking Union Medical College.
FAU - Xue, Jian
AU  - Xue J
AD  - Institute of Medicinal Plant Development, Chinese Academy of Medical Science & 
      Peking Union Medical College.
FAU - Wang, Pengsi
AU  - Wang P
AD  - Institute of Medicinal Plant Development, Chinese Academy of Medical Science & 
      Peking Union Medical College.
FAU - Shi, Shangmei
AU  - Shi S
AD  - Chinese Pharmacopoeia Commission.
LA  - eng
PT  - Journal Article
DEP - 20180314
PL  - Japan
TA  - Chem Pharm Bull (Tokyo)
JT  - Chemical & pharmaceutical bulletin
JID - 0377775
RN  - 0 (Plant Extracts)
RN  - 25X51I8RD4 (Niacinamide)
RN  - 4465L2WS4Y (lonicerae flos)
RN  - 9500W2Z53J (flonicamid)
SB  - IM
MH  - Dietary Exposure
MH  - Lonicera
MH  - Niacinamide/adverse effects/*analogs & derivatives/analysis
MH  - Plant Extracts/*chemistry
MH  - Risk Assessment
OTO - NOTNLM
OT  - Lonicerae Japonicae Flos
OT  - constituent
OT  - dietary exposure risk assessment
OT  - flonicamid
OT  - terminal pesticide residue
EDAT- 2018/03/16 06:00
MHDA- 2018/07/03 06:00
CRDT- 2018/03/16 06:00
PHST- 2018/03/16 06:00 [pubmed]
PHST- 2018/07/03 06:00 [medline]
PHST- 2018/03/16 06:00 [entrez]
AID - 10.1248/cpb.c17-00985 [doi]
PST - ppublish
SO  - Chem Pharm Bull (Tokyo). 2018 Jun 1;66(6):608-611. doi: 10.1248/cpb.c17-00985. 
      Epub 2018 Mar 14.