PMID- 29541037
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220316
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 9
DP  - 2018
TI  - Serum Brain-Derived Neurotrophic Factor, and Plasma Catecholamine Metabolites in 
      People with Major Depression: Preliminary Cross-Sectional Study.
PG  - 52
LID - 10.3389/fpsyt.2018.00052 [doi]
LID - 52
AB  - BACKGROUND: There are complicated interactions between catecholaminergic neurons 
      and brain-derived neurotrophic factor (BDNF) in the brain. However, no reports 
      have addressed the relationship among 3-methoxy-4-hydroxyphenylglycol (MHPG), 
      homovanillic acid (HVA), and BDNF in the blood. OBJECTIVE: This paper sought to 
      investigate correlations between serum BDNF and plasma levels of MHPG and HVA in 
      people with major depression (MD). MATERIALS AND METHODS: A total of 148 patients 
      (male/female 65/83, age 49.5 +/- 12.1 years old) who satisfied criteria for MD 
      based on the Diagnostic and Statistical Manual of Mental Disorders IV were 
      enrolled in the present study. Plasma levels of MHPG and HVA were analyzed using 
      high-performance liquid chromatography, and serum BDNF was measured using ELISA. 
      RESULTS: No interactions were observed between plasma HVA levels 
      (mean +/- SD = 4.5 +/- 1.5 ng/mL) and age, sex, HAMD scores, or serum BDNF levels 
      (mean +/- SD = 9.8 +/- 2.9 ng/mL). No correlations were not also observed between 
      plasma MHPG levels (mean +/- SD = 5.9 +/- 2.1 ng/mL) and age, sex, the HAMD17 scores 
      (mean +/- SD = 22.2 +/- 2.9 ng/mL), or serum BDNF levels. Serum BDNF levels were 
      negatively associated with HAMD17 scores. CONCLUSION: The results suggest that 
      there are no significant correlations between catecholamine metabolites and BDNF 
      in the blood for MDD patients.
FAU - Yoshimura, Reiji
AU  - Yoshimura R
AD  - Department of Psychiatry, School of Medicine, University of Occupational and 
      Environmental Health, Kitakyushu, Japan.
FAU - Kishi, Taro
AU  - Kishi T
AD  - Department of Psychiatry, School of Medicine, Fujita Health University, Toyoake, 
      Japan.
FAU - Atake, Kiyokazu
AU  - Atake K
AD  - Department of Psychiatry, School of Medicine, University of Occupational and 
      Environmental Health, Kitakyushu, Japan.
FAU - Katsuki, Asuka
AU  - Katsuki A
AD  - Department of Psychiatry, School of Medicine, University of Occupational and 
      Environmental Health, Kitakyushu, Japan.
FAU - Iwata, Nakao
AU  - Iwata N
AD  - Department of Psychiatry, School of Medicine, Fujita Health University, Toyoake, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20180228
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC5835900
OTO - NOTNLM
OT  - 3-methoxy-4-hydroxyphenylglycol
OT  - brain-derived neurotrophic factor
OT  - homovanillic acid
OT  - major depression
OT  - plasma
OT  - serum
EDAT- 2018/03/16 06:00
MHDA- 2018/03/16 06:01
PMCR- 2018/02/28
CRDT- 2018/03/16 06:00
PHST- 2017/12/09 00:00 [received]
PHST- 2018/02/06 00:00 [accepted]
PHST- 2018/03/16 06:00 [entrez]
PHST- 2018/03/16 06:00 [pubmed]
PHST- 2018/03/16 06:01 [medline]
PHST- 2018/02/28 00:00 [pmc-release]
AID - 10.3389/fpsyt.2018.00052 [doi]
PST - epublish
SO  - Front Psychiatry. 2018 Feb 28;9:52. doi: 10.3389/fpsyt.2018.00052. eCollection 
      2018.