PMID- 29541071
OWN - NLM
STAT- MEDLINE
DCOM- 20190327
LR  - 20191210
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 9
DP  - 2018
TI  - Tolerogenic Transcriptional Signatures of Steady-State and Pathogen-Induced 
      Dendritic Cells.
PG  - 333
LID - 10.3389/fimmu.2018.00333 [doi]
LID - 333
AB  - Dendritic cells (DCs) are key directors of tolerogenic and immunogenic immune 
      responses. During the steady state, DCs maintain T cell tolerance to 
      self-antigens by multiple mechanisms including inducing anergy, deletion, and 
      Treg activity. All of these mechanisms help to prevent autoimmune diseases or 
      other hyperreactivities. Different DC subsets contribute to pathogen recognition 
      by expression of different subsets of pattern recognition receptors, including 
      Toll-like receptors or C-type lectins. In addition to the triggering of immune 
      responses in infected hosts, most pathogens have evolved mechanisms for evasion 
      of targeted responses. One such strategy is characterized by adopting the host's 
      T cell tolerance mechanisms. Understanding these tolerogenic mechanisms is of 
      utmost importance for therapeutic approaches to treat immune pathologies, tumors 
      and infections. Transcriptional profiling has developed into a potent tool for DC 
      subset identification. Here, we review and compile pathogen-induced tolerogenic 
      transcriptional signatures from mRNA profiling data of currently available 
      bacterial- or helminth-induced transcriptional signatures. We compare them with 
      signatures of tolerogenic steady-state DC subtypes to identify common and 
      divergent strategies of pathogen induced immune evasion. Candidate molecules are 
      discussed in detail. Our analysis provides further insights into tolerogenic DC 
      signatures and their exploitation by different pathogens.
FAU - Vendelova, Emilia
AU  - Vendelova E
AD  - Institute for Virology and Immunobiology, University of Wurzburg, Wurzburg, 
      Germany.
FAU - Ashour, Diyaaeldin
AU  - Ashour D
AD  - Institute for Virology and Immunobiology, University of Wurzburg, Wurzburg, 
      Germany.
FAU - Blank, Patrick
AU  - Blank P
AD  - Institute for Experimental Infection Research, TWINCORE, Centre for Experimental 
      and Clinical Infection Research, a joint venture between the Helmholtz Centre for 
      Infection Research and the Hannover Medical School, Hannover, Germany.
FAU - Erhard, Florian
AU  - Erhard F
AD  - Institute for Virology and Immunobiology, University of Wurzburg, Wurzburg, 
      Germany.
FAU - Saliba, Antoine-Emmanuel
AU  - Saliba AE
AD  - Helmholtz Institute for RNA-Based Infection Research (HIRI), Wurzburg, Germany.
FAU - Kalinke, Ulrich
AU  - Kalinke U
AD  - Institute for Experimental Infection Research, TWINCORE, Centre for Experimental 
      and Clinical Infection Research, a joint venture between the Helmholtz Centre for 
      Infection Research and the Hannover Medical School, Hannover, Germany.
FAU - Lutz, Manfred B
AU  - Lutz MB
AD  - Institute for Virology and Immunobiology, University of Wurzburg, Wurzburg, 
      Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180228
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology/pathology
MH  - Host-Pathogen Interactions/*immunology
MH  - Humans
MH  - *Immune Tolerance
MH  - Infections/*immunology/pathology
MH  - Neoplasms/immunology/pathology
MH  - Tumor Escape
PMC - PMC5835767
OTO - NOTNLM
OT  - bacteria
OT  - helminths
OT  - immune evasion
OT  - mycobacteria
OT  - steady-state dendritic cells
OT  - tolerogenic dendritic cells
OT  - transcriptional profiling
EDAT- 2018/03/16 06:00
MHDA- 2018/03/16 06:01
PMCR- 2018/01/01
CRDT- 2018/03/16 06:00
PHST- 2017/10/24 00:00 [received]
PHST- 2018/02/06 00:00 [accepted]
PHST- 2018/03/16 06:00 [entrez]
PHST- 2018/03/16 06:00 [pubmed]
PHST- 2018/03/16 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2018.00333 [doi]
PST - epublish
SO  - Front Immunol. 2018 Feb 28;9:333. doi: 10.3389/fimmu.2018.00333. eCollection 
      2018.