PMID- 29541146
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231112
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2018
DP  - 2018
TI  - Association of Tongue Bacterial Flora and Subtypes of Liver-Fire Hyperactivity 
      Syndrome in Hypertensive Patients.
PG  - 9536924
LID - 10.1155/2018/9536924 [doi]
LID - 9536924
AB  - Structural changes in symbiotic human microorganisms can affect host phenotype. 
      Liver-fire hyperactivity syndrome (LFHS) presents as bitter taste, halitosis, 
      xerostomia, odontalgia, and other oral symptoms. LFHS is associated with 
      hypertension (EH). In this study, tongue flora was analyzed to further understand 
      the intrinsic relationship between tongue flora and LFHS. Samples of tongue 
      coating, from 16 patients with EH-LFHS, 16 with EH-non-LFHS, and 16 controls, 
      were obtained; then, 16S rRNA variable (V3-V4) regions were amplified and 
      sequenced by MiSeq PE300 Sequencing. Tag clustering and Operational Taxonomic 
      Units (OTUs) abundance analysis were used to compare the OTU sequence with the 
      16S database. The species were classified, and diversity and structure of the 
      bacterial flora were compared between the three groups. Alpha diversity analysis, 
      including Observed Species index and Chao index, indicated significantly higher 
      richness of species in patients with EH-LFHS (p < 0.05). Higher phylogenetic 
      diversity, in patients with EH-non-LFHS, indicates greater differences in 
      evolutionary history than in patients with EH-LFHS. Streptococcus, Rothia, 
      Neisseria, and Sphingomonas were the most prevalent in patients with EH-LFHS, 
      differed from the other two groups. This indicates that richer bacterial 
      diversity, and structure associated with EH-LFHS, may affect the occurrence, 
      development, and outcome of hypertension and syndrome subtypes recognized by TCM.
FAU - Luo, Jie-Wei
AU  - Luo JW
AUID- ORCID: 0000-0003-4271-4848
AD  - Provincial Clinical Medical College, Fujian Medical University, Fuzhou 350001, 
      China.
AD  - Department of Traditional Chinese Medicine, Fujian Provincial Hospital, Fuzhou 
      350001, China.
FAU - Lin, Cong-Huai
AU  - Lin CH
AD  - Department of Traditional Chinese Medicine, Fujian Provincial Hospital, Fuzhou 
      350001, China.
FAU - Zhu, Yao-Bin
AU  - Zhu YB
AD  - Provincial Clinical Medical College, Fujian Medical University, Fuzhou 350001, 
      China.
AD  - Department of Traditional Chinese Medicine, The First Affiliated Hospital, Fujian 
      Medical University, Fuzhou 350005, China.
FAU - Zheng, Xing-Yu
AU  - Zheng XY
AD  - Provincial Clinical Medical College, Fujian Medical University, Fuzhou 350001, 
      China.
AD  - Department of Traditional Chinese Medicine, Fujian Provincial Hospital, Fuzhou 
      350001, China.
FAU - Wu, Yong-Xi
AU  - Wu YX
AD  - Provincial Clinical Medical College, Fujian Medical University, Fuzhou 350001, 
      China.
AD  - Department of Traditional Chinese Medicine, Fujian Provincial Hospital, Fuzhou 
      350001, China.
FAU - Chen, Wei-Wei
AU  - Chen WW
AD  - Department of Traditional Chinese Medicine, Fujian Provincial Hospital, Fuzhou 
      350001, China.
FAU - Yang, Xiao
AU  - Yang X
AD  - Teaching and Research Office of Medical Cosmetology, Department of Management, 
      Fujian Health College, Fuzhou 350101, China.
LA  - eng
PT  - Journal Article
DEP - 20180110
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC5818919
EDAT- 2018/03/16 06:00
MHDA- 2018/03/16 06:01
PMCR- 2018/01/10
CRDT- 2018/03/16 06:00
PHST- 2017/07/10 00:00 [received]
PHST- 2017/12/04 00:00 [accepted]
PHST- 2018/03/16 06:00 [entrez]
PHST- 2018/03/16 06:00 [pubmed]
PHST- 2018/03/16 06:01 [medline]
PHST- 2018/01/10 00:00 [pmc-release]
AID - 10.1155/2018/9536924 [doi]
PST - epublish
SO  - Evid Based Complement Alternat Med. 2018 Jan 10;2018:9536924. doi: 
      10.1155/2018/9536924. eCollection 2018.