PMID- 29543591
OWN - NLM
STAT- MEDLINE
DCOM- 20190131
LR  - 20210213
IS  - 1619-3997 (Electronic)
IS  - 0300-5577 (Linking)
VI  - 46
IP  - 8
DP  - 2018 Oct 25
TI  - Effects of tributyltin on placental cytokine production.
PG  - 867-875
LID - 10.1515/jpm-2017-0336 [doi]
AB  - Objective Tributyltin (TBT) is a persistent pollutant but its effects on 
      placental function are poorly understood as are its possible interactions with 
      infection. We hypothesized that TBT alters the production of sex hormones and 
      biomarkers for inflammation and neurodevelopment in an infection-dependent 
      manner. Methods Placental explant cultures were treated with 0-5000 nM TBT in the 
      presence and absence of Escherichia coli. A conditioned medium was harvested and 
      concentrations of steroids (progesterone, P4; testosterone, T and estradiol, E2) 
      as well as biomarkers of inflammation [interleukin (IL)-1beta (IL-1beta), tumor 
      necrosis factor (TNF-alpha), IL-10, IL-6, soluble glycoprotein 130 (sgp-130) and heme 
      oxygenase-1 (HO-1)], oxidative stress [8-iso-prostaglandin (8-IsoP)] and 
      neurodevelopment [brain-derived neurotrophic factor (BDNF)] were quantified. 
      Results TBT increased P4 slightly but had little or no effect on T or E2 
      production. IL-1beta, IL-6, sgp-130, IL-10 and 8-IsoP production was enhanced by 
      TBT. P4 and IL-6 production was also enhanced by TBT for bacteria-stimulated 
      cultures but TBT significantly inhibited bacteria-induced IL-1beta and sgp-130 
      production. High doses of TBT also inhibited BDNF production. Conclusions TBT 
      increases P4 but has minimal effect on downstream steroids. It enhances the 
      production of inflammatory biomarkers such as IL-1beta, TNF-alpha, IL-10 and IL-6. 
      Inhibition of sgp-130 by TBT suggests that TBT may increase bioactive IL-6 
      production which has been associated with adverse neurodevelopmental outcomes. 
      Reduced expression of BDNF also supports this possibility.
FAU - Arita, Yuko
AU  - Arita Y
AD  - Department of Biomedical Research, NYU Winthrop Hospital, 101 Mineola Blvd, 
      Mineola, NY 11501, USA.
FAU - Kirk, Michael
AU  - Kirk M
AD  - Department of Biomedical Research, NYU Winthrop Hospital, 101 Mineola Blvd, 
      Mineola, NY 11501, USA.
FAU - Gupta, Neha
AU  - Gupta N
AD  - Department of Biomedical Research, NYU Winthrop Hospital, 101 Mineola Blvd, 
      Mineola, NY 11501, USA.
FAU - Menon, Ramkumar
AU  - Menon R
AD  - Department of Obstetrics and Gynecology, UTMB-Galveston, Galveston, TX, USA.
FAU - Getahun, Darios
AU  - Getahun D
AD  - Department of Research and Evaluation, Kaiser-Permenante Southern California, 
      Pasadena, CA, USA.
FAU - Peltier, Morgan R
AU  - Peltier MR
AD  - Department of Biomedical Research, NYU Winthrop Hospital, 101 Mineola Blvd, 
      Mineola, NY 11501, USA.
AD  - Department of Obstetrics and Gynecology, UTMB-Galveston, Galveston, TX, USA.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - J Perinat Med
JT  - Journal of perinatal medicine
JID - 0361031
RN  - 0 (Cytokines)
RN  - 0 (Trialkyltin Compounds)
RN  - 4XDX163P3D (tributyltin)
SB  - IM
MH  - Culture Techniques
MH  - Cytokines/*metabolism
MH  - Escherichia coli
MH  - Female
MH  - Humans
MH  - Placenta/*drug effects/metabolism
MH  - Pregnancy
MH  - Trialkyltin Compounds/*toxicity
OTO - NOTNLM
OT  - Autism
OT  - cytokine
OT  - environmental pollutants
OT  - infection
OT  - placenta
OT  - preterm birth
OT  - tributyltin
EDAT- 2018/03/16 06:00
MHDA- 2019/02/01 06:00
CRDT- 2018/03/16 06:00
PHST- 2017/10/26 00:00 [received]
PHST- 2018/02/06 00:00 [accepted]
PHST- 2018/03/16 06:00 [pubmed]
PHST- 2019/02/01 06:00 [medline]
PHST- 2018/03/16 06:00 [entrez]
AID - jpm-2017-0336 [pii]
AID - 10.1515/jpm-2017-0336 [doi]
PST - ppublish
SO  - J Perinat Med. 2018 Oct 25;46(8):867-875. doi: 10.1515/jpm-2017-0336.