PMID- 29544095
OWN - NLM
STAT- MEDLINE
DCOM- 20180924
LR  - 20200930
IS  - 1934-6069 (Electronic)
IS  - 1931-3128 (Linking)
VI  - 23
IP  - 3
DP  - 2018 Mar 14
TI  - A Sub-population of Group A Streptococcus Elicits a Population-wide Production of 
      Bacteriocins to Establish Dominance in the Host.
PG  - 312-323.e6
LID - S1931-3128(18)30088-X [pii]
LID - 10.1016/j.chom.2018.02.002 [doi]
AB  - Bacteria use quorum sensing (QS) to regulate gene expression. We identified a 
      group A Streptococcus (GAS) strain possessing the QS system sil, which produces 
      functional bacteriocins, through a sequential signaling pathway integrating host 
      and bacterial signals. Host cells infected by GAS release asparagine (ASN), which 
      is sensed by the bacteria to alter its gene expression and rate of proliferation. 
      We show that upon ASN sensing, GAS upregulates expression of the QS autoinducer 
      peptide SilCR. Initial SilCR expression activates the autoinduction cycle for 
      further SilCR production. The autoinduction process propagates throughout the GAS 
      population, resulting in bacteriocin production. Subcutaneous co-injection of 
      mice with a bacteriocin-producing strain and the globally disseminated M1T1 GAS 
      clone results in M1T1 killing within soft tissue. Thus, by sensing host signals, 
      a fraction of a bacterial population can trigger an autoinduction mechanism 
      mediated by QS, which acts on the entire bacterial community to outcompete other 
      bacteria within the infection.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Hertzog, Baruch B
AU  - Hertzog BB
AD  - Department of Microbiology and Molecular Genetics, The Institute for Medical 
      Research, Israel-Canada (IMRIC), The Hebrew University of Jerusalem, Faculty of 
      Medicine, Jerusalem 9112102, Israel.
FAU - Kaufman, Yael
AU  - Kaufman Y
AD  - Department of Microbiology and Molecular Genetics, The Institute for Medical 
      Research, Israel-Canada (IMRIC), The Hebrew University of Jerusalem, Faculty of 
      Medicine, Jerusalem 9112102, Israel.
FAU - Biswas, Debabrata
AU  - Biswas D
AD  - NUS-HUJ-CREATE Programme for Inflammation Research, Center for Research 
      Excellence & Technological Enterprise (CREATE), Department of Microbiology and 
      Immunology, National University of Singapore, Singapore 138602, Singapore.
FAU - Ravins, Miriam
AU  - Ravins M
AD  - Department of Microbiology and Molecular Genetics, The Institute for Medical 
      Research, Israel-Canada (IMRIC), The Hebrew University of Jerusalem, Faculty of 
      Medicine, Jerusalem 9112102, Israel.
FAU - Ambalavanan, Poornima
AU  - Ambalavanan P
AD  - NUS-HUJ-CREATE Programme for Inflammation Research, Center for Research 
      Excellence & Technological Enterprise (CREATE), Department of Microbiology and 
      Immunology, National University of Singapore, Singapore 138602, Singapore.
FAU - Wiener, Reuven
AU  - Wiener R
AD  - Department of Biochemistry and Molecular Biology, The Institute for Medical 
      Research, Israel-Canada (IMRIC), The Hebrew University of Jerusalem, Faculty of 
      Medicine, Jerusalem 9112102, Israel.
FAU - Angeli, Veronique
AU  - Angeli V
AD  - Department of Microbiology and Immunology, National University of Singapore; LSI 
      Immunology Programme, National University of Singapore, Singapore 117456, 
      Singapore.
FAU - Chen, Swaine L
AU  - Chen SL
AD  - Department of Medicine, Yong Loo Lin School of Medicine, National University of 
      Singapore, and Infectious Diseases Group, Genome Institute of Singapore, 
      Singapore 119074, Singapore.
FAU - Hanski, Emanuel
AU  - Hanski E
AD  - Department of Microbiology and Molecular Genetics, The Institute for Medical 
      Research, Israel-Canada (IMRIC), The Hebrew University of Jerusalem, Faculty of 
      Medicine, Jerusalem 9112102, Israel; NUS-HUJ-CREATE Programme for Inflammation 
      Research, Center for Research Excellence & Technological Enterprise (CREATE), 
      Department of Microbiology and Immunology, National University of Singapore, 
      Singapore 138602, Singapore. Electronic address: emanuelh@ekmd.huji.ac.il.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cell Host Microbe
JT  - Cell host & microbe
JID - 101302316
RN  - 0 (Bacterial Proteins)
RN  - 0 (Bacteriocins)
RN  - 0 (DNA, Bacterial)
RN  - 0 (Virulence Factors)
RN  - 7006-34-0 (Asparagine)
SB  - IM
CIN - Cell Host Microbe. 2018 Mar 14;23 (3):285-287. PMID: 29544091
MH  - Animals
MH  - Asparagine/metabolism
MH  - Bacterial Proteins
MH  - Bacteriocins/genetics/*metabolism
MH  - Cell Line
MH  - DNA, Bacterial/genetics
MH  - Female
MH  - Gene Expression Regulation, Bacterial
MH  - Genes, Bacterial/genetics
MH  - HeLa Cells
MH  - Humans
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Quorum Sensing
MH  - Signal Transduction
MH  - Streptococcal Infections/*metabolism/*microbiology
MH  - Streptococcus/genetics/isolation & purification/*metabolism/*pathogenicity
MH  - Virulence
MH  - Virulence Factors/genetics/metabolism
OTO - NOTNLM
OT  - asparagine
OT  - bacteriocins
OT  - group A Streptococcus
OT  - host sensing
OT  - micro-colonies
OT  - quorum sensing
OT  - sil
OT  - soft tissues
OT  - virulence
EDAT- 2018/03/16 06:00
MHDA- 2018/09/25 06:00
CRDT- 2018/03/16 06:00
PHST- 2017/08/03 00:00 [received]
PHST- 2017/12/26 00:00 [revised]
PHST- 2018/02/07 00:00 [accepted]
PHST- 2018/03/16 06:00 [entrez]
PHST- 2018/03/16 06:00 [pubmed]
PHST- 2018/09/25 06:00 [medline]
AID - S1931-3128(18)30088-X [pii]
AID - 10.1016/j.chom.2018.02.002 [doi]
PST - ppublish
SO  - Cell Host Microbe. 2018 Mar 14;23(3):312-323.e6. doi: 10.1016/j.chom.2018.02.002.