PMID- 29544228
OWN - NLM
STAT- MEDLINE
DCOM- 20181001
LR  - 20181001
IS  - 1439-0221 (Electronic)
IS  - 0032-0943 (Linking)
VI  - 84
IP  - 9-10
DP  - 2018 Jul
TI  - Lipid Nanocarriers for Oral Delivery of Serenoa repens CO2 Extract: A Study of 
      Microemulsion and Self-Microemulsifying Drug Delivery Systems.
PG  - 736-742
LID - 10.1055/a-0589-0474 [doi]
AB  - The aim of this study was the development and characterization of lipid 
      nanocarriers using food grade components for oral delivery of Serenoa repens 
      CO(2) extract, namely microemulsions (MEs) and self-microemulsifying drug 
      delivery systems (SMEDDSs) to improve the oral absorption. A commercial blend 
      (CB) containing 320 of S. repens CO(2) extract plus the aqueous soluble extracts 
      of nettle root and pineapple stem was formulated in two MEs and two SMEDDSs. The 
      optimized ME loaded with the CB (CBM2) had a very low content of water (only 
      17.3%). The drug delivery systems were characterized by dynamic light scattering, 
      transmission electron microscopy, and high-performance liquid chromatography 
      (HPLC) with a diode-array detector analyses in order to evaluate the size, the 
      homogeneity, the morphology, and the encapsulation efficiency. beta-carotene was 
      selected as marker for the quantitative HPLC analysis. Additionally, physical and 
      chemical stabilities were acceptable during 3 wk at 4  degrees C. Stability of these 
      nanocarriers in simulated stomach and intestinal conditions was proved. Finally, 
      the improvement of oral absorption of S. repens was studied in vitro using 
      parallel artificial membrane permeability assay. An enhancement of oral 
      permeation was found in both CBM2 and CBS2 nanoformulations comparing with the CB 
      and S. repens CO(2) extract. The best performance was obtained by the CBM2 
      nanoformulation (~ 17%) predicting a 30 - 70% passive oral human absorption in 
      vivo.
CI  - Georg Thieme Verlag KG Stuttgart . New York.
FAU - Guccione, Clizia
AU  - Guccione C
AD  - Department of Chemistry, University of Florence, Sesto Fiorentino (Florence), 
      Italy.
FAU - Bergonzi, Maria Camilla
AU  - Bergonzi MC
AD  - Department of Chemistry, University of Florence, Sesto Fiorentino (Florence), 
      Italy.
FAU - Awada, Khaled M
AU  - Awada KM
AD  - Department of Chemistry, University of Florence, Sesto Fiorentino (Florence), 
      Italy.
FAU - Piazzini, Vieri
AU  - Piazzini V
AD  - Department of Chemistry, University of Florence, Sesto Fiorentino (Florence), 
      Italy.
FAU - Bilia, Anna Rita
AU  - Bilia AR
AD  - Department of Chemistry, University of Florence, Sesto Fiorentino (Florence), 
      Italy.
LA  - eng
PT  - Journal Article
DEP - 20180315
PL  - Germany
TA  - Planta Med
JT  - Planta medica
JID - 0066751
RN  - 0 (Emulsions)
RN  - 0 (Lipids)
RN  - 01YAE03M7J (beta Carotene)
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
MH  - Administration, Oral
MH  - Carbon Dioxide/*administration & dosage
MH  - *Drug Delivery Systems
MH  - Emulsions
MH  - Humans
MH  - Lipids/*chemistry
MH  - *Nanotechnology
MH  - Serenoa/*chemistry
MH  - beta Carotene/*administration & dosage
COIS- The authors declare no conflict of interest.
EDAT- 2018/03/16 06:00
MHDA- 2018/10/03 06:00
CRDT- 2018/03/16 06:00
PHST- 2018/03/16 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
PHST- 2018/03/16 06:00 [entrez]
AID - 10.1055/a-0589-0474 [doi]
PST - ppublish
SO  - Planta Med. 2018 Jul;84(9-10):736-742. doi: 10.1055/a-0589-0474. Epub 2018 Mar 
      15.