PMID- 29544814
OWN - NLM
STAT- MEDLINE
DCOM- 20180918
LR  - 20180918
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 79
IP  - 6
DP  - 2018 Jun
TI  - HLA-G and vertical mother-to-child transmission of human papillomavirus 
      infection.
PG  - 471-476
LID - S0198-8859(18)30066-1 [pii]
LID - 10.1016/j.humimm.2018.03.002 [doi]
AB  - Role of host factors in transmission of human papillomavirus (HPV)-infection from 
      mother to her offspring is not known. Our aim was to study whether human 
      leukocyte antigen (HLA)-G allele concordance among the mother-child pairs could 
      facilitate vertical transmission of HPV, because HLA-G may contribute to immune 
      tolerance in pregnancy. Altogether, 310 mother-child pairs were included from the 
      Finnish Family HPV study. Overall, nine different HLA-G alleles were identified. 
      The HLA-G genotype concordance of G( *)01:01:01/01:04:01 increased the risk of 
      high risk (HR)-HPV genotype positivity in cord blood and infant's oral mucosa. 
      The mother-child concordance of G( *)01:01:02/01:01:02 increased the risk of oral 
      HPV positivity with HR-HPV genotypes both in the mother and offspring; OR 2.45 
      (95%CI 1.24-4.85). Discordant HLA-G allele for G( *)01:04:01 and for G( *)01:06 was 
      significantly associated with infant's oral low risk (LR)-HPV at birth, OR 3.07 
      (95%CI 1.01-9.36) and OR 5.19 (95%CI 1.22-22.03), respectively. HLA-G had no 
      association with HPV genotype-specific concordance between the mother and child 
      at birth nor influence on perinatal HPV status of the child. Taken together, our 
      results show that HLA-G molecules have a role in predicting the newborn's 
      likelihood for oral HPV infection at birth.
CI  - Copyright (c) 2018 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Louvanto, Karolina
AU  - Louvanto K
AD  - Department of Obstetrics and Gynaecology, Turku University Hospital, University 
      of Turku, Kiinanmyllynkatu 13, 20520 Turku, Finland; Wolfson Institute of 
      Preventive Medicine, Queen Mary University of London, Charterhouse Square, London 
      EC1M 6BQ, UK; Department of Oral Pathology and Radiology, University of Turku, 
      Lemminkaisenkatu 2, 20520 Turku, Finland. Electronic address: 
      karolina.louvanto@utu.fi.
FAU - Roger, Michel
AU  - Roger M
AD  - Centre de Recherche du CHUM et Departement de Microbiologie, Infectiologie et 
      Immunologie, Universite de Montreal, 2900, boul. Edouard-Montpetit, Montreal H3T 
      1J4, Canada. Electronic address: michel.roger.chum@ssss.gouv.qc.ca.
FAU - Faucher, Marie-Claude
AU  - Faucher MC
AD  - Centre de Recherche du CHUM et Departement de Microbiologie, Infectiologie et 
      Immunologie, Universite de Montreal, 2900, boul. Edouard-Montpetit, Montreal H3T 
      1J4, Canada. Electronic address: marie-claude.faucher.chum@ssss.gouv.qc.ca.
FAU - Syrjanen, Kari
AU  - Syrjanen K
AD  - Department of Obstetrics and Gynaecology, Turku University Hospital, University 
      of Turku, Kiinanmyllynkatu 13, 20520 Turku, Finland; Department of Clinical 
      Research, Biohit Oyj, Laippatie 1, 00880 Helsinki, Finland. Electronic address: 
      kari.syrjanen@biohit.fi.
FAU - Grenman, Seija
AU  - Grenman S
AD  - Department of Obstetrics and Gynaecology, Turku University Hospital, University 
      of Turku, Kiinanmyllynkatu 13, 20520 Turku, Finland. Electronic address: 
      seija.grenman@tyks.fi.
FAU - Syrjanen, Stina
AU  - Syrjanen S
AD  - Department of Oral Pathology and Radiology, University of Turku, Lemminkaisenkatu 
      2, 20520 Turku, Finland; Department of Pathology, Turku University Hospital, 
      Kiinanmyllynkatu 10, 20520 Turku, Finland. Electronic address: 
      stina.syrjanen@utu.fi.
LA  - eng
PT  - Journal Article
DEP - 20180312
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - Alleles
MH  - Female
MH  - Finland
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-G Antigens/*genetics
MH  - Histocompatibility
MH  - Humans
MH  - Immune Tolerance
MH  - Infant
MH  - Infant, Newborn
MH  - Infant, Newborn, Diseases/*immunology
MH  - Infectious Disease Transmission, Vertical
MH  - Mouth Mucosa/*physiology/virology
MH  - Papillomaviridae/*immunology
MH  - Papillomavirus Infections/*immunology/transmission
MH  - Polymorphism, Genetic
MH  - Pregnancy
OTO - NOTNLM
OT  - HLA-G
OT  - Human papillomavirus
OT  - Mother
OT  - Newborn
OT  - Vertical transmission
EDAT- 2018/03/17 06:00
MHDA- 2018/09/19 06:00
CRDT- 2018/03/17 06:00
PHST- 2017/10/18 00:00 [received]
PHST- 2018/03/06 00:00 [revised]
PHST- 2018/03/06 00:00 [accepted]
PHST- 2018/03/17 06:00 [pubmed]
PHST- 2018/09/19 06:00 [medline]
PHST- 2018/03/17 06:00 [entrez]
AID - S0198-8859(18)30066-1 [pii]
AID - 10.1016/j.humimm.2018.03.002 [doi]
PST - ppublish
SO  - Hum Immunol. 2018 Jun;79(6):471-476. doi: 10.1016/j.humimm.2018.03.002. Epub 2018 
      Mar 12.