PMID- 29544858
OWN - NLM
STAT- MEDLINE
DCOM- 20191220
LR  - 20220408
IS  - 1522-9653 (Electronic)
IS  - 1063-4584 (Linking)
VI  - 26
IP  - 6
DP  - 2018 Jun
TI  - Osteoarthritis and stem cell therapy in humans: a systematic review.
PG  - 711-729
LID - S1063-4584(18)31080-X [pii]
LID - 10.1016/j.joca.2018.02.906 [doi]
AB  - OBJECTIVE: Osteoarthritis (OA) is a leading cause of disability in the world. 
      Mesenchymal stem cells (MSCs) have been studied to treat OA. This review was 
      performed to systematically assess the quality of literature and compare the 
      procedural specifics surrounding MSC therapy for osteoarthritis. DESIGN: PubMed, 
      CINAHL, EMBASE and Cochrane Central Register of Controlled Trials were searched 
      for studies using MSCs for OA treatment (final search December 2017). Outcomes of 
      interest included study evidence level, patient demographics, MSC protocol, 
      treatment results and adverse events. Level I and II evidence articles were 
      further analyzed. RESULTS: Sixty-one of 3,172 articles were identified. These 
      studies treated 2,390 patients with osteoarthritis. Most used adipose-derived 
      stem cells (ADSCs) (n = 29) or bone marrow-derived stem cells (BMSCs) (n = 30) 
      though the preparation varied within group. 57% of the sixty-one studies were 
      level IV evidence, leaving five level I and nine level II studies containing 288 
      patients to be further analyzed. Eight studies used BMSCs, five ADSCs and one 
      peripheral blood stem cells (PBSCs). The risk of bias in these studies showed 
      five level I studies at low risk with seven level II at moderate and two at high 
      risk. CONCLUSION: While studies support the notion that MSC therapy has a 
      positive effect on OA patients, there is limited high quality evidence and 
      long-term follow-up. The present study summarizes the specifics of high level 
      evidence studies and identifies a lack of consistency, including a diversity of 
      MSC preparations, and thus a lack of reproducibility amongst these articles' 
      methods.
CI  - Copyright (c) 2018 Osteoarthritis Research Society International. Published by 
      Elsevier Ltd. All rights reserved.
FAU - Jevotovsky, D S
AU  - Jevotovsky DS
AD  - Department of Orthopaedic Surgery, NYU Langone Health, New York, NY, USA. 
      Electronic address: david.jevotovsky@nyumc.org.
FAU - Alfonso, A R
AU  - Alfonso AR
AD  - Hansjorg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY, 
      USA.
FAU - Einhorn, T A
AU  - Einhorn TA
AD  - Department of Orthopaedic Surgery, NYU Langone Health, New York, NY, USA.
FAU - Chiu, E S
AU  - Chiu ES
AD  - Hansjorg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY, 
      USA. Electronic address: ernest.chiu@nyumc.org.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20180313
PL  - England
TA  - Osteoarthritis Cartilage
JT  - Osteoarthritis and cartilage
JID - 9305697
SB  - IM
MH  - Humans
MH  - Osteoarthritis/*surgery
MH  - *Stem Cell Transplantation/methods
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Level of evidence
OT  - Mesenchymal stem cells
OT  - Osteoarthritis
OT  - Stem cell therapy
OT  - Systematic review
EDAT- 2018/03/17 06:00
MHDA- 2019/12/21 06:00
CRDT- 2018/03/17 06:00
PHST- 2017/07/24 00:00 [received]
PHST- 2018/01/21 00:00 [revised]
PHST- 2018/02/27 00:00 [accepted]
PHST- 2018/03/17 06:00 [pubmed]
PHST- 2019/12/21 06:00 [medline]
PHST- 2018/03/17 06:00 [entrez]
AID - S1063-4584(18)31080-X [pii]
AID - 10.1016/j.joca.2018.02.906 [doi]
PST - ppublish
SO  - Osteoarthritis Cartilage. 2018 Jun;26(6):711-729. doi: 
      10.1016/j.joca.2018.02.906. Epub 2018 Mar 13.