PMID- 29545027
OWN - NLM
STAT- MEDLINE
DCOM- 20190315
LR  - 20190315
IS  - 1873-5177 (Electronic)
IS  - 0091-3057 (Linking)
VI  - 168
DP  - 2018 May
TI  - Early paracetamol exposure decreases brain-derived neurotrophic factor (BDNF) in 
      striatum and affects social behaviour and exploration in rats.
PG  - 25-32
LID - S0091-3057(17)30711-6 [pii]
LID - 10.1016/j.pbb.2018.03.004 [doi]
AB  - The biochemical and behavioral responses to prenatal and early postnatal exposure 
      to paracetamol in rats are not well understood. The effect of daily maternal and 
      early life administration of 5 mg/kg (group P5) or 15 mg/kg paracetamol (group 
      P15) was evaluated in two-month old male rats, relative to control animals 
      receiving tap water (Con). Social behavior and episodic memory were investigated 
      with Social Interaction and Novel Object Recognition (NOR) tests. Quantification 
      of brain-derived neurotrophic factor (BDNF) was determined in prefrontal cortex, 
      hippocampus and striatum using enzyme-linked immunosorbent assay (ELISA). Control 
      animals exhibited a higher total frequency of social interactions and greater 
      frequency of sniffing compared to rats exposed to paracetamol, and we found a 
      statistically significant increase in the occurrence of pinning in 
      paracetamol-treated animals. Rats from the 15 mg/kg group exhibited a greater 
      interest in objects in the NOR test and spent more time exploring objects during 
      the familiarization and choice phases. Biochemical analysis showed significant 
      differences in striatal BDNF between the groups, specifically, a nearly two-fold 
      decrease in striatal BDNF in the paracetamol groups (P5: 6.78 +/- 0.60 pg/mg; P15: 
      6.06 +/- 0.46 pg/mg) relative to the control group (Con: 11.33 +/- 2.00 pg/mg). These 
      results indicate that paracetamol exposure induces changes in social behaviour 
      and exploration in rats and results in a significant decrease of striatal BDNF.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Blecharz-Klin, Kamilla
AU  - Blecharz-Klin K
AD  - Department of Experimental and Clinical Pharmacology, Medical University of 
      Warsaw, Centre for Preclinical Research and Technology CePT, Banacha 1B, 02-097 
      Warsaw, Poland.
FAU - Wawer, Adriana
AU  - Wawer A
AD  - Department of Experimental and Clinical Pharmacology, Medical University of 
      Warsaw, Centre for Preclinical Research and Technology CePT, Banacha 1B, 02-097 
      Warsaw, Poland.
FAU - Jawna-Zboinska, Katarzyna
AU  - Jawna-Zboinska K
AD  - Department of Experimental and Clinical Pharmacology, Medical University of 
      Warsaw, Centre for Preclinical Research and Technology CePT, Banacha 1B, 02-097 
      Warsaw, Poland.
FAU - Pyrzanowska, Justyna
AU  - Pyrzanowska J
AD  - Department of Experimental and Clinical Pharmacology, Medical University of 
      Warsaw, Centre for Preclinical Research and Technology CePT, Banacha 1B, 02-097 
      Warsaw, Poland. Electronic address: justyna.pyrzanowska@wum.edu.pl.
FAU - Piechal, Agnieszka
AU  - Piechal A
AD  - Department of Experimental and Clinical Pharmacology, Medical University of 
      Warsaw, Centre for Preclinical Research and Technology CePT, Banacha 1B, 02-097 
      Warsaw, Poland.
FAU - Mirowska-Guzel, Dagmara
AU  - Mirowska-Guzel D
AD  - Department of Experimental and Clinical Pharmacology, Medical University of 
      Warsaw, Centre for Preclinical Research and Technology CePT, Banacha 1B, 02-097 
      Warsaw, Poland.
FAU - Widy-Tyszkiewicz, Ewa
AU  - Widy-Tyszkiewicz E
AD  - Department of Experimental and Clinical Pharmacology, Medical University of 
      Warsaw, Centre for Preclinical Research and Technology CePT, Banacha 1B, 02-097 
      Warsaw, Poland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180313
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 0 (Bdnf protein, rat)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 362O9ITL9D (Acetaminophen)
SB  - IM
MH  - Acetaminophen/administration & dosage/*pharmacology
MH  - Analgesics, Non-Narcotic/*pharmacology
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cognition/drug effects
MH  - Corpus Striatum/*drug effects/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Exploratory Behavior/*drug effects
MH  - Female
MH  - Male
MH  - *Maternal Exposure
MH  - Motor Activity/drug effects
MH  - Pregnancy
MH  - Rats, Wistar
MH  - *Social Behavior
OTO - NOTNLM
OT  - Acetaminophen
OT  - BDNF
OT  - Memory
OT  - Paracetamol
OT  - Social behavior
OT  - Striatum
EDAT- 2018/03/17 06:00
MHDA- 2019/03/16 06:00
CRDT- 2018/03/17 06:00
PHST- 2017/12/22 00:00 [received]
PHST- 2018/02/07 00:00 [revised]
PHST- 2018/03/12 00:00 [accepted]
PHST- 2018/03/17 06:00 [pubmed]
PHST- 2019/03/16 06:00 [medline]
PHST- 2018/03/17 06:00 [entrez]
AID - S0091-3057(17)30711-6 [pii]
AID - 10.1016/j.pbb.2018.03.004 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2018 May;168:25-32. doi: 10.1016/j.pbb.2018.03.004. Epub 
      2018 Mar 13.