PMID- 29545230
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1309-0399 (Print)
IS  - 1309-0380 (Electronic)
IS  - 1309-0380 (Linking)
VI  - 19
IP  - 2
DP  - 2018 Jun 4
TI  - Does progesterone have protective effects on ovarian ischemia-reperfusion injury?
PG  - 87-93
LID - 10.4274/jtgga.2017.0047 [doi]
AB  - OBJECTIVE: The aim of the present study was to evaluate the effects of 
      progesterone (PG) against ovarian ischemia-reperfusion (I/R) injury through the 
      evaluation of biochemical and histopathologic parameters. MATERIAL AND METHODS: 
      Twenty-one female Wistar albino rats were divided into three groups. Group 1: 
      Sham; group 2: I/R; group 3: I/R+PG (8 mg/kg). PG was administered 
      intraperitoneally to the rats in group 3, 30 minutes before a detorsion 
      operation. Ovarian I/R injury was evaluated in serum and tissue by using 
      biochemical parameters including malondialdehyde (MDA), total antioxidant status 
      (TAS), total oxidant status (TOS), oxidative stress index, neutrophil 
      gelatinase-associated lipocalin (NGAL) and immunofluorescence staining by using a 
      terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) 
      assay. RESULTS: Serum and tissue TOS levels were significantly lower in group 3 
      than in group 2. Tissue TAS levels were higher in group 3 than in group 2 
      (p<0.001). NGAL and MDA levels were similar between the groups. Histologic score, 
      including vascular congestion, hemorrhage, polymorphonuclear neutrophils, and 
      interstitial edema, was higher in group 2. Pre-treatment with PG decreased the 
      score, but this difference was not statistically significant. The number of 
      apoptotic cells was higher in group 2 than in groups 1 and 3. The TUNEL-positive 
      cell number decreased with PG in group 3. CONCLUSION: Preoperative PG treatment 
      might exert protective effects on ovarian I/R injury through its anti-apoptotic 
      and antioxidative properties.
FAU - Gulec Baser, Banu
AU  - Gulec Baser B
AD  - Department of Obstetrics and Gynecology, Balikesir University School of Medicine, 
      Balikesir, Turkey
FAU - Islimye Taskin, Mine
AU  - Islimye Taskin M
AD  - Department of Obstetrics and Gynecology, Balikesir University School of Medicine, 
      Balikesir, Turkey
FAU - Adali, Ertan
AU  - Adali E
AD  - Department of Obstetrics and Gynecology, Balikesir University School of Medicine, 
      Balikesir, Turkey
FAU - Ozturk, Emine
AU  - Ozturk E
AD  - Department of Obstetrics and Gynecology, Balikesir University School of Medicine, 
      Balikesir, Turkey
FAU - Hismiogullari, Adnan Adil
AU  - Hismiogullari AA
AD  - Department of Biochemistry, Balikesir University School of Medicine, Balikesir, 
      Turkey
FAU - Yay, Arzu
AU  - Yay A
AD  - Department of Histology and Embryology, Erciyes University School of Medicine, 
      Kayseri, Turkey
LA  - eng
PT  - Journal Article
DEP - 20180316
PL  - Turkey
TA  - J Turk Ger Gynecol Assoc
JT  - Journal of the Turkish German Gynecological Association
JID - 101272522
PMC - PMC5994815
OTO - NOTNLM
OT  - Ischemia-reperfusion
OT  - NGAL
OT  - progesterone
COIS- Conflict of Interest: No conflict of interest is declared by the authors.
EDAT- 2018/03/17 06:00
MHDA- 2018/03/17 06:01
PMCR- 2018/06/04
CRDT- 2018/03/17 06:00
PHST- 2018/03/17 06:00 [entrez]
PHST- 2018/03/17 06:00 [pubmed]
PHST- 2018/03/17 06:01 [medline]
PHST- 2018/06/04 00:00 [pmc-release]
AID - 16803 [pii]
AID - 10.4274/jtgga.2017.0047 [doi]
PST - ppublish
SO  - J Turk Ger Gynecol Assoc. 2018 Jun 4;19(2):87-93. doi: 10.4274/jtgga.2017.0047. 
      Epub 2018 Mar 16.