PMID- 29545386
OWN - NLM
STAT- MEDLINE
DCOM- 20190204
LR  - 20190215
IS  - 1549-5485 (Electronic)
IS  - 1072-0502 (Print)
IS  - 1072-0502 (Linking)
VI  - 25
IP  - 4
DP  - 2018 Apr
TI  - alpha(2)-Adrenergic receptor activation promotes long-term potentiation at excitatory 
      synapses in the mouse accessory olfactory bulb.
PG  - 147-157
LID - 10.1101/lm.046391.117 [doi]
AB  - The formation of mate recognition memory in mice is associated with neural 
      changes at the reciprocal dendrodendritic synapses between glutamatergic mitral 
      cell (MC) projection neurons and GABAergic granule cell (GC) interneurons in the 
      accessory olfactory bulb (AOB). Although noradrenaline (NA) plays a critical role 
      in the formation of the memory, the mechanism by which it exerts this effect 
      remains unclear. Here we used extracellular field potential and whole-cell 
      patch-clamp recordings to assess the actions of bath-applied NA (10 microM) on the 
      glutamatergic transmission and its plasticity at the MC-to-GC synapse in the AOB. 
      Stimulation (400 stimuli) of MC axons at 10 Hz but not at 100 Hz effectively 
      induced N-methyl-d-aspartate (NMDA) receptor-dependent long-term potentiation 
      (LTP), which exhibited reversibility. NA paired with subthreshold 10-Hz 
      stimulation (200 stimuli) facilitated the induction of NMDA receptor-dependent 
      LTP via the activation of alpha(2)-adrenergic receptors (ARs). We next examined how 
      NA, acting at alpha(2)-ARs, facilitates LTP induction. In terms of acute actions, NA 
      suppressed GC excitatory postsynaptic current (EPSC) responses to single pulse 
      stimulation of MC axons by reducing glutamate release from MCs via G-protein 
      coupled inhibition of calcium channels. Consequently, NA reduced recurrent 
      inhibition of MCs, resulting in the enhancement of evoked EPSCs and spike 
      fidelity in GCs during the 10-Hz stimulation used to induce LTP. These results 
      suggest that NA, acting at alpha(2)-ARs, facilitates the induction of NMDA 
      receptor-dependent LTP at the MC-to-GC synapse by shifting its threshold through 
      disinhibition of MCs.
CI  - (c) 2018 Huang et al.; Published by Cold Spring Harbor Laboratory Press.
FAU - Huang, Guang-Zhe
AU  - Huang GZ
AD  - Department of Physiology, Kochi Medical School, Kochi University, Nankoku, Kochi 
      783-8505, Japan.
AD  - CREST, Japan Science and Technology Corporation, Saitama 332-0012, Japan.
FAU - Taniguchi, Mutsuo
AU  - Taniguchi M
AD  - Department of Physiology, Kochi Medical School, Kochi University, Nankoku, Kochi 
      783-8505, Japan.
AD  - CREST, Japan Science and Technology Corporation, Saitama 332-0012, Japan.
FAU - Zhou, Ye-Bo
AU  - Zhou YB
AD  - Department of Physiology, Kochi Medical School, Kochi University, Nankoku, Kochi 
      783-8505, Japan.
FAU - Zhang, Jing-Ji
AU  - Zhang JJ
AD  - Department of Physiology, Kochi Medical School, Kochi University, Nankoku, Kochi 
      783-8505, Japan.
AD  - CREST, Japan Science and Technology Corporation, Saitama 332-0012, Japan.
FAU - Okutani, Fumino
AU  - Okutani F
AD  - Department of Physiology, Kochi Medical School, Kochi University, Nankoku, Kochi 
      783-8505, Japan.
AD  - CREST, Japan Science and Technology Corporation, Saitama 332-0012, Japan.
FAU - Murata, Yoshihiro
AU  - Murata Y
AD  - Department of Physiology, Kochi Medical School, Kochi University, Nankoku, Kochi 
      783-8505, Japan.
FAU - Yamaguchi, Masahiro
AU  - Yamaguchi M
AD  - Department of Physiology, Kochi Medical School, Kochi University, Nankoku, Kochi 
      783-8505, Japan.
FAU - Kaba, Hideto
AU  - Kaba H
AD  - Department of Physiology, Kochi Medical School, Kochi University, Nankoku, Kochi 
      783-8505, Japan kabah@kochi-u.ac.jp.
AD  - CREST, Japan Science and Technology Corporation, Saitama 332-0012, Japan.
AD  - Division of Adaptation Development, Department of Developmental Physiology, 
      National Institute for Physiological Sciences, Okazaki 444-8585, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180315
PL  - United States
TA  - Learn Mem
JT  - Learning & memory (Cold Spring Harbor, N.Y.)
JID - 9435678
RN  - 0 (Receptors, Adrenergic, alpha-2)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
SB  - IM
MH  - Action Potentials
MH  - Animals
MH  - Excitatory Postsynaptic Potentials
MH  - Glutamic Acid/metabolism
MH  - Interneurons/physiology
MH  - *Long-Term Potentiation
MH  - Mice, Inbred BALB C
MH  - Neurons/*physiology
MH  - Olfactory Bulb/*physiology
MH  - Receptors, Adrenergic, alpha-2/*physiology
MH  - Receptors, N-Methyl-D-Aspartate/physiology
MH  - Synapses/*physiology
MH  - gamma-Aminobutyric Acid/metabolism
PMC - PMC5855524
EDAT- 2018/03/17 06:00
MHDA- 2019/02/05 06:00
PMCR- 2018/04/01
CRDT- 2018/03/17 06:00
PHST- 2017/08/13 00:00 [received]
PHST- 2018/01/22 00:00 [accepted]
PHST- 2018/03/17 06:00 [entrez]
PHST- 2018/03/17 06:00 [pubmed]
PHST- 2019/02/05 06:00 [medline]
PHST- 2018/04/01 00:00 [pmc-release]
AID - 25/4/147 [pii]
AID - LM046391Hua [pii]
AID - 10.1101/lm.046391.117 [doi]
PST - epublish
SO  - Learn Mem. 2018 Mar 15;25(4):147-157. doi: 10.1101/lm.046391.117. Print 2018 Apr.