PMID- 29545632
OWN - NLM
STAT- MEDLINE
DCOM- 20190909
LR  - 20190909
IS  - 1572-0241 (Electronic)
IS  - 0002-9270 (Linking)
VI  - 113
IP  - 7
DP  - 2018 Jul
TI  - Helicobacter pylori infection does not protect against eosinophilic esophagitis: 
      results from a large multicenter case-control study.
PG  - 972-979
LID - 10.1038/s41395-018-0035-6 [doi]
AB  - OBJECTIVES: Rising trends in eosinophilic esophagitis (EoE) have been repeatedly 
      linked to declining Helicobacter pylori (H. pylori) infection, mostly in 
      retrospective studies. We aimed to prospectively evaluate this inverse 
      association. METHODS: Prospective case-control study conducted in 23 centers. 
      Children and adults naive to eradication therapy for H. pylori were included. 
      Cases were EoE patients, whereas controls were defined by esophageal symptoms and 
      <5 eos/HPF on esophageal biopsies. H. pylori status was diagnosed by non-invasive 
      (excluding serology) or invasive testing off proton pump inhibitor (PPI) therapy 
      for 2 weeks. Atopy was defined by the presence of IgE-mediated conditions 
      diagnosed by an allergist. RESULTS: 808 individuals, including 404 cases and 404 
      controls (170 children) were enrolled. Overall H. pylori prevalence was 38% (45% 
      children vs. 37% adults, p 0.009) and was not different between cases and 
      controls (37% vs. 40%, p 0.3; odds ratio (OR) 0.97; 95% confidence interval (CI) 
      0.73-1.30), neither in children (42% vs. 46%, p 0.1) nor in adults (36% vs. 38%, 
      p 0.4). Atopy (OR 0.85; 95%CI 0.75-0.98) and allergic rhinitis (OR 0.81; 95%CI 
      0.68-0.98) showed a borderline inverse association with H. pylori infection in 
      EoE patients. This trend was not confirmed for asthma or food allergy. 
      CONCLUSIONS: H. pylori infection was not inversely associated with EoE, neither 
      in children nor in adults. A borderline inverse association was confirmed for 
      atopy and allergic rhinitis, but not asthma of food allergy. Our findings 
      question a true protective role of H. pylori infection against allergic 
      disorders, including EoE.
FAU - Molina-Infante, Javier
AU  - Molina-Infante J
AD  - Department of Gastroenterology, Hospital Universitario San Pedro de Alcantara, 
      Caceres, Spain. Centro de Investigacion Biomedica en Red de Enfermedades 
      Hepaticas y Digestivas (CIBEREHD), Madrid, Spain. Department of Pediatrics, 
      Pediatric Gastroenterology Unit, Hospital Universitario Puerta de 
      Hierro-Majadahonda, Madrid, Spain. Department of Surgery, Division of 
      Gastroenterology, Oncology and Gastroenterology, University of Padua, Padua, 
      Italy. Gastroenterology and Endoscopy Unit, Universita degli Studi di Milano, 
      Milan, Italy. Department of Gastroenterology, Consorci Sanitari Terrassa, 
      Barcelona, Spain. Department of Allergy, Hospital Universitario Gregorio Maranon, 
      Madrid, Spain. Department of Gastroenterology, Hospital Universitario Miguel 
      Servet, Zaragoza, Spain. Department of Gastroenterology, Hospital de Viladecans, 
      Barcelona, Spain. Department of Gastroenterology, Hospital de la Santa Creu I 
      Sant Pau, Barcelona, Spain. Department of Gastroenterology, Hospital Clinico 
      Universitario, Valladolid, Spain. Clinical Analysis and Pediatrics, Hospital 
      Universitario Rio Hortega, Valladolid, Spain. Department of Pediatrics, Hospital 
      Universitario San Pedro de Alcantara, Caceres, Spain. Department of 
      Gastroenterology, Hospital Quiron, Marbella, Spain. Departement of 
      Gastroenterology, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP), and CIBEREHD, Madrid, Spain. 
      Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, and 
      CIBEREHD, Ciudad Real, Spain.
AD  - Department of Gastroenterology, Hospital Universitario San Pedro de Alcantara, 
      Caceres, Spain. Centro de Investigacion Biomedica en Red de Enfermedades 
      Hepaticas y Digestivas (CIBEREHD), Madrid, Spain. Department of Pediatrics, 
      Pediatric Gastroenterology Unit, Hospital Universitario Puerta de 
      Hierro-Majadahonda, Madrid, Spain. Department of Surgery, Division of 
      Gastroenterology, Oncology and Gastroenterology, University of Padua, Padua, 
      Italy. Gastroenterology and Endoscopy Unit, Universita degli Studi di Milano, 
      Milan, Italy. Department of Gastroenterology, Consorci Sanitari Terrassa, 
      Barcelona, Spain. Department of Allergy, Hospital Universitario Gregorio Maranon, 
      Madrid, Spain. Department of Gastroenterology, Hospital Universitario Miguel 
      Servet, Zaragoza, Spain. Department of Gastroenterology, Hospital de Viladecans, 
      Barcelona, Spain. Department of Gastroenterology, Hospital de la Santa Creu I 
      Sant Pau, Barcelona, Spain. Department of Gastroenterology, Hospital Clinico 
      Universitario, Valladolid, Spain. Clinical Analysis and Pediatrics, Hospital 
      Universitario Rio Hortega, Valladolid, Spain. Department of Pediatrics, Hospital 
      Universitario San Pedro de Alcantara, Caceres, Spain. Department of 
      Gastroenterology, Hospital Quiron, Marbella, Spain. Departement of 
      Gastroenterology, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP), and CIBEREHD, Madrid, Spain. 
      Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, and 
      CIBEREHD, Ciudad Real, Spain.
FAU - Gutierrez-Junquera, Carolina
AU  - Gutierrez-Junquera C
AD  - Department of Gastroenterology, Hospital Universitario San Pedro de Alcantara, 
      Caceres, Spain. Centro de Investigacion Biomedica en Red de Enfermedades 
      Hepaticas y Digestivas (CIBEREHD), Madrid, Spain. Department of Pediatrics, 
      Pediatric Gastroenterology Unit, Hospital Universitario Puerta de 
      Hierro-Majadahonda, Madrid, Spain. Department of Surgery, Division of 
      Gastroenterology, Oncology and Gastroenterology, University of Padua, Padua, 
      Italy. Gastroenterology and Endoscopy Unit, Universita degli Studi di Milano, 
      Milan, Italy. Department of Gastroenterology, Consorci Sanitari Terrassa, 
      Barcelona, Spain. Department of Allergy, Hospital Universitario Gregorio Maranon, 
      Madrid, Spain. Department of Gastroenterology, Hospital Universitario Miguel 
      Servet, Zaragoza, Spain. Department of Gastroenterology, Hospital de Viladecans, 
      Barcelona, Spain. Department of Gastroenterology, Hospital de la Santa Creu I 
      Sant Pau, Barcelona, Spain. Department of Gastroenterology, Hospital Clinico 
      Universitario, Valladolid, Spain. Clinical Analysis and Pediatrics, Hospital 
      Universitario Rio Hortega, Valladolid, Spain. Department of Pediatrics, Hospital 
      Universitario San Pedro de Alcantara, Caceres, Spain. Department of 
      Gastroenterology, Hospital Quiron, Marbella, Spain. Departement of 
      Gastroenterology, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP), and CIBEREHD, Madrid, Spain. 
      Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, and 
      CIBEREHD, Ciudad Real, Spain.
FAU - Savarino, Edoardo
AU  - Savarino E
AD  - Department of Gastroenterology, Hospital Universitario San Pedro de Alcantara, 
      Caceres, Spain. Centro de Investigacion Biomedica en Red de Enfermedades 
      Hepaticas y Digestivas (CIBEREHD), Madrid, Spain. Department of Pediatrics, 
      Pediatric Gastroenterology Unit, Hospital Universitario Puerta de 
      Hierro-Majadahonda, Madrid, Spain. Department of Surgery, Division of 
      Gastroenterology, Oncology and Gastroenterology, University of Padua, Padua, 
      Italy. Gastroenterology and Endoscopy Unit, Universita degli Studi di Milano, 
      Milan, Italy. Department of Gastroenterology, Consorci Sanitari Terrassa, 
      Barcelona, Spain. Department of Allergy, Hospital Universitario Gregorio Maranon, 
      Madrid, Spain. Department of Gastroenterology, Hospital Universitario Miguel 
      Servet, Zaragoza, Spain. Department of Gastroenterology, Hospital de Viladecans, 
      Barcelona, Spain. Department of Gastroenterology, Hospital de la Santa Creu I 
      Sant Pau, Barcelona, Spain. Department of Gastroenterology, Hospital Clinico 
      Universitario, Valladolid, Spain. Clinical Analysis and Pediatrics, Hospital 
      Universitario Rio Hortega, Valladolid, Spain. Department of Pediatrics, Hospital 
      Universitario San Pedro de Alcantara, Caceres, Spain. Department of 
      Gastroenterology, Hospital Quiron, Marbella, Spain. Departement of 
      Gastroenterology, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP), and CIBEREHD, Madrid, Spain. 
      Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, and 
      CIBEREHD, Ciudad Real, Spain.
FAU - Penagini, Roberto
AU  - Penagini R
AD  - Department of Gastroenterology, Hospital Universitario San Pedro de Alcantara, 
      Caceres, Spain. Centro de Investigacion Biomedica en Red de Enfermedades 
      Hepaticas y Digestivas (CIBEREHD), Madrid, Spain. Department of Pediatrics, 
      Pediatric Gastroenterology Unit, Hospital Universitario Puerta de 
      Hierro-Majadahonda, Madrid, Spain. Department of Surgery, Division of 
      Gastroenterology, Oncology and Gastroenterology, University of Padua, Padua, 
      Italy. Gastroenterology and Endoscopy Unit, Universita degli Studi di Milano, 
      Milan, Italy. Department of Gastroenterology, Consorci Sanitari Terrassa, 
      Barcelona, Spain. Department of Allergy, Hospital Universitario Gregorio Maranon, 
      Madrid, Spain. Department of Gastroenterology, Hospital Universitario Miguel 
      Servet, Zaragoza, Spain. Department of Gastroenterology, Hospital de Viladecans, 
      Barcelona, Spain. Department of Gastroenterology, Hospital de la Santa Creu I 
      Sant Pau, Barcelona, Spain. Department of Gastroenterology, Hospital Clinico 
      Universitario, Valladolid, Spain. Clinical Analysis and Pediatrics, Hospital 
      Universitario Rio Hortega, Valladolid, Spain. Department of Pediatrics, Hospital 
      Universitario San Pedro de Alcantara, Caceres, Spain. Department of 
      Gastroenterology, Hospital Quiron, Marbella, Spain. Departement of 
      Gastroenterology, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP), and CIBEREHD, Madrid, Spain. 
      Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, and 
      CIBEREHD, Ciudad Real, Spain.
FAU - Modolell, Ines
AU  - Modolell I
AD  - Department of Gastroenterology, Hospital Universitario San Pedro de Alcantara, 
      Caceres, Spain. Centro de Investigacion Biomedica en Red de Enfermedades 
      Hepaticas y Digestivas (CIBEREHD), Madrid, Spain. Department of Pediatrics, 
      Pediatric Gastroenterology Unit, Hospital Universitario Puerta de 
      Hierro-Majadahonda, Madrid, Spain. Department of Surgery, Division of 
      Gastroenterology, Oncology and Gastroenterology, University of Padua, Padua, 
      Italy. Gastroenterology and Endoscopy Unit, Universita degli Studi di Milano, 
      Milan, Italy. Department of Gastroenterology, Consorci Sanitari Terrassa, 
      Barcelona, Spain. Department of Allergy, Hospital Universitario Gregorio Maranon, 
      Madrid, Spain. Department of Gastroenterology, Hospital Universitario Miguel 
      Servet, Zaragoza, Spain. Department of Gastroenterology, Hospital de Viladecans, 
      Barcelona, Spain. Department of Gastroenterology, Hospital de la Santa Creu I 
      Sant Pau, Barcelona, Spain. Department of Gastroenterology, Hospital Clinico 
      Universitario, Valladolid, Spain. Clinical Analysis and Pediatrics, Hospital 
      Universitario Rio Hortega, Valladolid, Spain. Department of Pediatrics, Hospital 
      Universitario San Pedro de Alcantara, Caceres, Spain. Department of 
      Gastroenterology, Hospital Quiron, Marbella, Spain. Departement of 
      Gastroenterology, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP), and CIBEREHD, Madrid, Spain. 
      Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, and 
      CIBEREHD, Ciudad Real, Spain.
FAU - Bartolo, Ottavia
AU  - Bartolo O
AD  - Department of Gastroenterology, Hospital Universitario San Pedro de Alcantara, 
      Caceres, Spain. Centro de Investigacion Biomedica en Red de Enfermedades 
      Hepaticas y Digestivas (CIBEREHD), Madrid, Spain. Department of Pediatrics, 
      Pediatric Gastroenterology Unit, Hospital Universitario Puerta de 
      Hierro-Majadahonda, Madrid, Spain. Department of Surgery, Division of 
      Gastroenterology, Oncology and Gastroenterology, University of Padua, Padua, 
      Italy. Gastroenterology and Endoscopy Unit, Universita degli Studi di Milano, 
      Milan, Italy. Department of Gastroenterology, Consorci Sanitari Terrassa, 
      Barcelona, Spain. Department of Allergy, Hospital Universitario Gregorio Maranon, 
      Madrid, Spain. Department of Gastroenterology, Hospital Universitario Miguel 
      Servet, Zaragoza, Spain. Department of Gastroenterology, Hospital de Viladecans, 
      Barcelona, Spain. Department of Gastroenterology, Hospital de la Santa Creu I 
      Sant Pau, Barcelona, Spain. Department of Gastroenterology, Hospital Clinico 
      Universitario, Valladolid, Spain. Clinical Analysis and Pediatrics, Hospital 
      Universitario Rio Hortega, Valladolid, Spain. Department of Pediatrics, Hospital 
      Universitario San Pedro de Alcantara, Caceres, Spain. Department of 
      Gastroenterology, Hospital Quiron, Marbella, Spain. Departement of 
      Gastroenterology, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP), and CIBEREHD, Madrid, Spain. 
      Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, and 
      CIBEREHD, Ciudad Real, Spain.
FAU - Prieto-Garcia, Alicia
AU  - Prieto-Garcia A
AD  - Department of Gastroenterology, Hospital Universitario San Pedro de Alcantara, 
      Caceres, Spain. Centro de Investigacion Biomedica en Red de Enfermedades 
      Hepaticas y Digestivas (CIBEREHD), Madrid, Spain. Department of Pediatrics, 
      Pediatric Gastroenterology Unit, Hospital Universitario Puerta de 
      Hierro-Majadahonda, Madrid, Spain. Department of Surgery, Division of 
      Gastroenterology, Oncology and Gastroenterology, University of Padua, Padua, 
      Italy. Gastroenterology and Endoscopy Unit, Universita degli Studi di Milano, 
      Milan, Italy. Department of Gastroenterology, Consorci Sanitari Terrassa, 
      Barcelona, Spain. Department of Allergy, Hospital Universitario Gregorio Maranon, 
      Madrid, Spain. Department of Gastroenterology, Hospital Universitario Miguel 
      Servet, Zaragoza, Spain. Department of Gastroenterology, Hospital de Viladecans, 
      Barcelona, Spain. Department of Gastroenterology, Hospital de la Santa Creu I 
      Sant Pau, Barcelona, Spain. Department of Gastroenterology, Hospital Clinico 
      Universitario, Valladolid, Spain. Clinical Analysis and Pediatrics, Hospital 
      Universitario Rio Hortega, Valladolid, Spain. Department of Pediatrics, Hospital 
      Universitario San Pedro de Alcantara, Caceres, Spain. Department of 
      Gastroenterology, Hospital Quiron, Marbella, Spain. Departement of 
      Gastroenterology, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP), and CIBEREHD, Madrid, Spain. 
      Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, and 
      CIBEREHD, Ciudad Real, Spain.
FAU - Mauro, Aurelio
AU  - Mauro A
AD  - Department of Gastroenterology, Hospital Universitario San Pedro de Alcantara, 
      Caceres, Spain. Centro de Investigacion Biomedica en Red de Enfermedades 
      Hepaticas y Digestivas (CIBEREHD), Madrid, Spain. Department of Pediatrics, 
      Pediatric Gastroenterology Unit, Hospital Universitario Puerta de 
      Hierro-Majadahonda, Madrid, Spain. Department of Surgery, Division of 
      Gastroenterology, Oncology and Gastroenterology, University of Padua, Padua, 
      Italy. Gastroenterology and Endoscopy Unit, Universita degli Studi di Milano, 
      Milan, Italy. Department of Gastroenterology, Consorci Sanitari Terrassa, 
      Barcelona, Spain. Department of Allergy, Hospital Universitario Gregorio Maranon, 
      Madrid, Spain. Department of Gastroenterology, Hospital Universitario Miguel 
      Servet, Zaragoza, Spain. Department of Gastroenterology, Hospital de Viladecans, 
      Barcelona, Spain. Department of Gastroenterology, Hospital de la Santa Creu I 
      Sant Pau, Barcelona, Spain. Department of Gastroenterology, Hospital Clinico 
      Universitario, Valladolid, Spain. Clinical Analysis and Pediatrics, Hospital 
      Universitario Rio Hortega, Valladolid, Spain. Department of Pediatrics, Hospital 
      Universitario San Pedro de Alcantara, Caceres, Spain. Department of 
      Gastroenterology, Hospital Quiron, Marbella, Spain. Departement of 
      Gastroenterology, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP), and CIBEREHD, Madrid, Spain. 
      Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, and 
      CIBEREHD, Ciudad Real, Spain.
FAU - Alcedo, Javier
AU  - Alcedo J
AD  - Department of Gastroenterology, Hospital Universitario San Pedro de Alcantara, 
      Caceres, Spain. Centro de Investigacion Biomedica en Red de Enfermedades 
      Hepaticas y Digestivas (CIBEREHD), Madrid, Spain. Department of Pediatrics, 
      Pediatric Gastroenterology Unit, Hospital Universitario Puerta de 
      Hierro-Majadahonda, Madrid, Spain. Department of Surgery, Division of 
      Gastroenterology, Oncology and Gastroenterology, University of Padua, Padua, 
      Italy. Gastroenterology and Endoscopy Unit, Universita degli Studi di Milano, 
      Milan, Italy. Department of Gastroenterology, Consorci Sanitari Terrassa, 
      Barcelona, Spain. Department of Allergy, Hospital Universitario Gregorio Maranon, 
      Madrid, Spain. Department of Gastroenterology, Hospital Universitario Miguel 
      Servet, Zaragoza, Spain. Department of Gastroenterology, Hospital de Viladecans, 
      Barcelona, Spain. Department of Gastroenterology, Hospital de la Santa Creu I 
      Sant Pau, Barcelona, Spain. Department of Gastroenterology, Hospital Clinico 
      Universitario, Valladolid, Spain. Clinical Analysis and Pediatrics, Hospital 
      Universitario Rio Hortega, Valladolid, Spain. Department of Pediatrics, Hospital 
      Universitario San Pedro de Alcantara, Caceres, Spain. Department of 
      Gastroenterology, Hospital Quiron, Marbella, Spain. Departement of 
      Gastroenterology, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP), and CIBEREHD, Madrid, Spain. 
      Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, and 
      CIBEREHD, Ciudad Real, Spain.
FAU - Perello, Antonia
AU  - Perello A
AD  - Department of Gastroenterology, Hospital Universitario San Pedro de Alcantara, 
      Caceres, Spain. Centro de Investigacion Biomedica en Red de Enfermedades 
      Hepaticas y Digestivas (CIBEREHD), Madrid, Spain. Department of Pediatrics, 
      Pediatric Gastroenterology Unit, Hospital Universitario Puerta de 
      Hierro-Majadahonda, Madrid, Spain. Department of Surgery, Division of 
      Gastroenterology, Oncology and Gastroenterology, University of Padua, Padua, 
      Italy. Gastroenterology and Endoscopy Unit, Universita degli Studi di Milano, 
      Milan, Italy. Department of Gastroenterology, Consorci Sanitari Terrassa, 
      Barcelona, Spain. Department of Allergy, Hospital Universitario Gregorio Maranon, 
      Madrid, Spain. Department of Gastroenterology, Hospital Universitario Miguel 
      Servet, Zaragoza, Spain. Department of Gastroenterology, Hospital de Viladecans, 
      Barcelona, Spain. Department of Gastroenterology, Hospital de la Santa Creu I 
      Sant Pau, Barcelona, Spain. Department of Gastroenterology, Hospital Clinico 
      Universitario, Valladolid, Spain. Clinical Analysis and Pediatrics, Hospital 
      Universitario Rio Hortega, Valladolid, Spain. Department of Pediatrics, Hospital 
      Universitario San Pedro de Alcantara, Caceres, Spain. Department of 
      Gastroenterology, Hospital Quiron, Marbella, Spain. Departement of 
      Gastroenterology, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP), and CIBEREHD, Madrid, Spain. 
      Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, and 
      CIBEREHD, Ciudad Real, Spain.
FAU - Guarner-Argente, Carlos
AU  - Guarner-Argente C
AD  - Department of Gastroenterology, Hospital Universitario San Pedro de Alcantara, 
      Caceres, Spain. Centro de Investigacion Biomedica en Red de Enfermedades 
      Hepaticas y Digestivas (CIBEREHD), Madrid, Spain. Department of Pediatrics, 
      Pediatric Gastroenterology Unit, Hospital Universitario Puerta de 
      Hierro-Majadahonda, Madrid, Spain. Department of Surgery, Division of 
      Gastroenterology, Oncology and Gastroenterology, University of Padua, Padua, 
      Italy. Gastroenterology and Endoscopy Unit, Universita degli Studi di Milano, 
      Milan, Italy. Department of Gastroenterology, Consorci Sanitari Terrassa, 
      Barcelona, Spain. Department of Allergy, Hospital Universitario Gregorio Maranon, 
      Madrid, Spain. Department of Gastroenterology, Hospital Universitario Miguel 
      Servet, Zaragoza, Spain. Department of Gastroenterology, Hospital de Viladecans, 
      Barcelona, Spain. Department of Gastroenterology, Hospital de la Santa Creu I 
      Sant Pau, Barcelona, Spain. Department of Gastroenterology, Hospital Clinico 
      Universitario, Valladolid, Spain. Clinical Analysis and Pediatrics, Hospital 
      Universitario Rio Hortega, Valladolid, Spain. Department of Pediatrics, Hospital 
      Universitario San Pedro de Alcantara, Caceres, Spain. Department of 
      Gastroenterology, Hospital Quiron, Marbella, Spain. Departement of 
      Gastroenterology, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP), and CIBEREHD, Madrid, Spain. 
      Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, and 
      CIBEREHD, Ciudad Real, Spain.
FAU - Alcaide, Noelia
AU  - Alcaide N
AD  - Department of Gastroenterology, Hospital Universitario San Pedro de Alcantara, 
      Caceres, Spain. Centro de Investigacion Biomedica en Red de Enfermedades 
      Hepaticas y Digestivas (CIBEREHD), Madrid, Spain. Department of Pediatrics, 
      Pediatric Gastroenterology Unit, Hospital Universitario Puerta de 
      Hierro-Majadahonda, Madrid, Spain. Department of Surgery, Division of 
      Gastroenterology, Oncology and Gastroenterology, University of Padua, Padua, 
      Italy. Gastroenterology and Endoscopy Unit, Universita degli Studi di Milano, 
      Milan, Italy. Department of Gastroenterology, Consorci Sanitari Terrassa, 
      Barcelona, Spain. Department of Allergy, Hospital Universitario Gregorio Maranon, 
      Madrid, Spain. Department of Gastroenterology, Hospital Universitario Miguel 
      Servet, Zaragoza, Spain. Department of Gastroenterology, Hospital de Viladecans, 
      Barcelona, Spain. Department of Gastroenterology, Hospital de la Santa Creu I 
      Sant Pau, Barcelona, Spain. Department of Gastroenterology, Hospital Clinico 
      Universitario, Valladolid, Spain. Clinical Analysis and Pediatrics, Hospital 
      Universitario Rio Hortega, Valladolid, Spain. Department of Pediatrics, Hospital 
      Universitario San Pedro de Alcantara, Caceres, Spain. Department of 
      Gastroenterology, Hospital Quiron, Marbella, Spain. Departement of 
      Gastroenterology, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP), and CIBEREHD, Madrid, Spain. 
      Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, and 
      CIBEREHD, Ciudad Real, Spain.
FAU - Vegas, Ana M
AU  - Vegas AM
AD  - Department of Gastroenterology, Hospital Universitario San Pedro de Alcantara, 
      Caceres, Spain. Centro de Investigacion Biomedica en Red de Enfermedades 
      Hepaticas y Digestivas (CIBEREHD), Madrid, Spain. Department of Pediatrics, 
      Pediatric Gastroenterology Unit, Hospital Universitario Puerta de 
      Hierro-Majadahonda, Madrid, Spain. Department of Surgery, Division of 
      Gastroenterology, Oncology and Gastroenterology, University of Padua, Padua, 
      Italy. Gastroenterology and Endoscopy Unit, Universita degli Studi di Milano, 
      Milan, Italy. Department of Gastroenterology, Consorci Sanitari Terrassa, 
      Barcelona, Spain. Department of Allergy, Hospital Universitario Gregorio Maranon, 
      Madrid, Spain. Department of Gastroenterology, Hospital Universitario Miguel 
      Servet, Zaragoza, Spain. Department of Gastroenterology, Hospital de Viladecans, 
      Barcelona, Spain. Department of Gastroenterology, Hospital de la Santa Creu I 
      Sant Pau, Barcelona, Spain. Department of Gastroenterology, Hospital Clinico 
      Universitario, Valladolid, Spain. Clinical Analysis and Pediatrics, Hospital 
      Universitario Rio Hortega, Valladolid, Spain. Department of Pediatrics, Hospital 
      Universitario San Pedro de Alcantara, Caceres, Spain. Department of 
      Gastroenterology, Hospital Quiron, Marbella, Spain. Departement of 
      Gastroenterology, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP), and CIBEREHD, Madrid, Spain. 
      Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, and 
      CIBEREHD, Ciudad Real, Spain.
FAU - Barros-Garcia, Patricia
AU  - Barros-Garcia P
AD  - Department of Gastroenterology, Hospital Universitario San Pedro de Alcantara, 
      Caceres, Spain. Centro de Investigacion Biomedica en Red de Enfermedades 
      Hepaticas y Digestivas (CIBEREHD), Madrid, Spain. Department of Pediatrics, 
      Pediatric Gastroenterology Unit, Hospital Universitario Puerta de 
      Hierro-Majadahonda, Madrid, Spain. Department of Surgery, Division of 
      Gastroenterology, Oncology and Gastroenterology, University of Padua, Padua, 
      Italy. Gastroenterology and Endoscopy Unit, Universita degli Studi di Milano, 
      Milan, Italy. Department of Gastroenterology, Consorci Sanitari Terrassa, 
      Barcelona, Spain. Department of Allergy, Hospital Universitario Gregorio Maranon, 
      Madrid, Spain. Department of Gastroenterology, Hospital Universitario Miguel 
      Servet, Zaragoza, Spain. Department of Gastroenterology, Hospital de Viladecans, 
      Barcelona, Spain. Department of Gastroenterology, Hospital de la Santa Creu I 
      Sant Pau, Barcelona, Spain. Department of Gastroenterology, Hospital Clinico 
      Universitario, Valladolid, Spain. Clinical Analysis and Pediatrics, Hospital 
      Universitario Rio Hortega, Valladolid, Spain. Department of Pediatrics, Hospital 
      Universitario San Pedro de Alcantara, Caceres, Spain. Department of 
      Gastroenterology, Hospital Quiron, Marbella, Spain. Departement of 
      Gastroenterology, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP), and CIBEREHD, Madrid, Spain. 
      Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, and 
      CIBEREHD, Ciudad Real, Spain.
FAU - Murzi-Pulgar, Marianette
AU  - Murzi-Pulgar M
AD  - Department of Gastroenterology, Hospital Universitario San Pedro de Alcantara, 
      Caceres, Spain. Centro de Investigacion Biomedica en Red de Enfermedades 
      Hepaticas y Digestivas (CIBEREHD), Madrid, Spain. Department of Pediatrics, 
      Pediatric Gastroenterology Unit, Hospital Universitario Puerta de 
      Hierro-Majadahonda, Madrid, Spain. Department of Surgery, Division of 
      Gastroenterology, Oncology and Gastroenterology, University of Padua, Padua, 
      Italy. Gastroenterology and Endoscopy Unit, Universita degli Studi di Milano, 
      Milan, Italy. Department of Gastroenterology, Consorci Sanitari Terrassa, 
      Barcelona, Spain. Department of Allergy, Hospital Universitario Gregorio Maranon, 
      Madrid, Spain. Department of Gastroenterology, Hospital Universitario Miguel 
      Servet, Zaragoza, Spain. Department of Gastroenterology, Hospital de Viladecans, 
      Barcelona, Spain. Department of Gastroenterology, Hospital de la Santa Creu I 
      Sant Pau, Barcelona, Spain. Department of Gastroenterology, Hospital Clinico 
      Universitario, Valladolid, Spain. Clinical Analysis and Pediatrics, Hospital 
      Universitario Rio Hortega, Valladolid, Spain. Department of Pediatrics, Hospital 
      Universitario San Pedro de Alcantara, Caceres, Spain. Department of 
      Gastroenterology, Hospital Quiron, Marbella, Spain. Departement of 
      Gastroenterology, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP), and CIBEREHD, Madrid, Spain. 
      Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, and 
      CIBEREHD, Ciudad Real, Spain.
FAU - Perona, Monica
AU  - Perona M
AD  - Department of Gastroenterology, Hospital Universitario San Pedro de Alcantara, 
      Caceres, Spain. Centro de Investigacion Biomedica en Red de Enfermedades 
      Hepaticas y Digestivas (CIBEREHD), Madrid, Spain. Department of Pediatrics, 
      Pediatric Gastroenterology Unit, Hospital Universitario Puerta de 
      Hierro-Majadahonda, Madrid, Spain. Department of Surgery, Division of 
      Gastroenterology, Oncology and Gastroenterology, University of Padua, Padua, 
      Italy. Gastroenterology and Endoscopy Unit, Universita degli Studi di Milano, 
      Milan, Italy. Department of Gastroenterology, Consorci Sanitari Terrassa, 
      Barcelona, Spain. Department of Allergy, Hospital Universitario Gregorio Maranon, 
      Madrid, Spain. Department of Gastroenterology, Hospital Universitario Miguel 
      Servet, Zaragoza, Spain. Department of Gastroenterology, Hospital de Viladecans, 
      Barcelona, Spain. Department of Gastroenterology, Hospital de la Santa Creu I 
      Sant Pau, Barcelona, Spain. Department of Gastroenterology, Hospital Clinico 
      Universitario, Valladolid, Spain. Clinical Analysis and Pediatrics, Hospital 
      Universitario Rio Hortega, Valladolid, Spain. Department of Pediatrics, Hospital 
      Universitario San Pedro de Alcantara, Caceres, Spain. Department of 
      Gastroenterology, Hospital Quiron, Marbella, Spain. Departement of 
      Gastroenterology, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP), and CIBEREHD, Madrid, Spain. 
      Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, and 
      CIBEREHD, Ciudad Real, Spain.
FAU - Gisbert, Javier P
AU  - Gisbert JP
AD  - Department of Gastroenterology, Hospital Universitario San Pedro de Alcantara, 
      Caceres, Spain. Centro de Investigacion Biomedica en Red de Enfermedades 
      Hepaticas y Digestivas (CIBEREHD), Madrid, Spain. Department of Pediatrics, 
      Pediatric Gastroenterology Unit, Hospital Universitario Puerta de 
      Hierro-Majadahonda, Madrid, Spain. Department of Surgery, Division of 
      Gastroenterology, Oncology and Gastroenterology, University of Padua, Padua, 
      Italy. Gastroenterology and Endoscopy Unit, Universita degli Studi di Milano, 
      Milan, Italy. Department of Gastroenterology, Consorci Sanitari Terrassa, 
      Barcelona, Spain. Department of Allergy, Hospital Universitario Gregorio Maranon, 
      Madrid, Spain. Department of Gastroenterology, Hospital Universitario Miguel 
      Servet, Zaragoza, Spain. Department of Gastroenterology, Hospital de Viladecans, 
      Barcelona, Spain. Department of Gastroenterology, Hospital de la Santa Creu I 
      Sant Pau, Barcelona, Spain. Department of Gastroenterology, Hospital Clinico 
      Universitario, Valladolid, Spain. Clinical Analysis and Pediatrics, Hospital 
      Universitario Rio Hortega, Valladolid, Spain. Department of Pediatrics, Hospital 
      Universitario San Pedro de Alcantara, Caceres, Spain. Department of 
      Gastroenterology, Hospital Quiron, Marbella, Spain. Departement of 
      Gastroenterology, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP), and CIBEREHD, Madrid, Spain. 
      Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, and 
      CIBEREHD, Ciudad Real, Spain.
AD  - Department of Gastroenterology, Hospital Universitario San Pedro de Alcantara, 
      Caceres, Spain. Centro de Investigacion Biomedica en Red de Enfermedades 
      Hepaticas y Digestivas (CIBEREHD), Madrid, Spain. Department of Pediatrics, 
      Pediatric Gastroenterology Unit, Hospital Universitario Puerta de 
      Hierro-Majadahonda, Madrid, Spain. Department of Surgery, Division of 
      Gastroenterology, Oncology and Gastroenterology, University of Padua, Padua, 
      Italy. Gastroenterology and Endoscopy Unit, Universita degli Studi di Milano, 
      Milan, Italy. Department of Gastroenterology, Consorci Sanitari Terrassa, 
      Barcelona, Spain. Department of Allergy, Hospital Universitario Gregorio Maranon, 
      Madrid, Spain. Department of Gastroenterology, Hospital Universitario Miguel 
      Servet, Zaragoza, Spain. Department of Gastroenterology, Hospital de Viladecans, 
      Barcelona, Spain. Department of Gastroenterology, Hospital de la Santa Creu I 
      Sant Pau, Barcelona, Spain. Department of Gastroenterology, Hospital Clinico 
      Universitario, Valladolid, Spain. Clinical Analysis and Pediatrics, Hospital 
      Universitario Rio Hortega, Valladolid, Spain. Department of Pediatrics, Hospital 
      Universitario San Pedro de Alcantara, Caceres, Spain. Department of 
      Gastroenterology, Hospital Quiron, Marbella, Spain. Departement of 
      Gastroenterology, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP), and CIBEREHD, Madrid, Spain. 
      Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, and 
      CIBEREHD, Ciudad Real, Spain.
FAU - Lucendo, Alfredo J
AU  - Lucendo AJ
AD  - Department of Gastroenterology, Hospital Universitario San Pedro de Alcantara, 
      Caceres, Spain. Centro de Investigacion Biomedica en Red de Enfermedades 
      Hepaticas y Digestivas (CIBEREHD), Madrid, Spain. Department of Pediatrics, 
      Pediatric Gastroenterology Unit, Hospital Universitario Puerta de 
      Hierro-Majadahonda, Madrid, Spain. Department of Surgery, Division of 
      Gastroenterology, Oncology and Gastroenterology, University of Padua, Padua, 
      Italy. Gastroenterology and Endoscopy Unit, Universita degli Studi di Milano, 
      Milan, Italy. Department of Gastroenterology, Consorci Sanitari Terrassa, 
      Barcelona, Spain. Department of Allergy, Hospital Universitario Gregorio Maranon, 
      Madrid, Spain. Department of Gastroenterology, Hospital Universitario Miguel 
      Servet, Zaragoza, Spain. Department of Gastroenterology, Hospital de Viladecans, 
      Barcelona, Spain. Department of Gastroenterology, Hospital de la Santa Creu I 
      Sant Pau, Barcelona, Spain. Department of Gastroenterology, Hospital Clinico 
      Universitario, Valladolid, Spain. Clinical Analysis and Pediatrics, Hospital 
      Universitario Rio Hortega, Valladolid, Spain. Department of Pediatrics, Hospital 
      Universitario San Pedro de Alcantara, Caceres, Spain. Department of 
      Gastroenterology, Hospital Quiron, Marbella, Spain. Departement of 
      Gastroenterology, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP), and CIBEREHD, Madrid, Spain. 
      Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, and 
      CIBEREHD, Ciudad Real, Spain.
AD  - Department of Gastroenterology, Hospital Universitario San Pedro de Alcantara, 
      Caceres, Spain. Centro de Investigacion Biomedica en Red de Enfermedades 
      Hepaticas y Digestivas (CIBEREHD), Madrid, Spain. Department of Pediatrics, 
      Pediatric Gastroenterology Unit, Hospital Universitario Puerta de 
      Hierro-Majadahonda, Madrid, Spain. Department of Surgery, Division of 
      Gastroenterology, Oncology and Gastroenterology, University of Padua, Padua, 
      Italy. Gastroenterology and Endoscopy Unit, Universita degli Studi di Milano, 
      Milan, Italy. Department of Gastroenterology, Consorci Sanitari Terrassa, 
      Barcelona, Spain. Department of Allergy, Hospital Universitario Gregorio Maranon, 
      Madrid, Spain. Department of Gastroenterology, Hospital Universitario Miguel 
      Servet, Zaragoza, Spain. Department of Gastroenterology, Hospital de Viladecans, 
      Barcelona, Spain. Department of Gastroenterology, Hospital de la Santa Creu I 
      Sant Pau, Barcelona, Spain. Department of Gastroenterology, Hospital Clinico 
      Universitario, Valladolid, Spain. Clinical Analysis and Pediatrics, Hospital 
      Universitario Rio Hortega, Valladolid, Spain. Department of Pediatrics, Hospital 
      Universitario San Pedro de Alcantara, Caceres, Spain. Department of 
      Gastroenterology, Hospital Quiron, Marbella, Spain. Departement of 
      Gastroenterology, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP), and CIBEREHD, Madrid, Spain. 
      Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, and 
      CIBEREHD, Ciudad Real, Spain.
CN  - Upper GI Tract Study Group from the Spanish Gastroenterological Association (AEG)
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20180315
PL  - United States
TA  - Am J Gastroenterol
JT  - The American journal of gastroenterology
JID - 0421030
SB  - IM
CIN - Am J Gastroenterol. 2018 Jul;113(7):941-944. PMID: 29910462
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Case-Control Studies
MH  - Child
MH  - Colombia/epidemiology
MH  - Eosinophilic Esophagitis/complications/*epidemiology
MH  - Female
MH  - France/epidemiology
MH  - Helicobacter Infections/*complications
MH  - *Helicobacter pylori
MH  - Humans
MH  - Italy/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Prospective Studies
MH  - Spain/epidemiology
MH  - Young Adult
EDAT- 2018/03/17 06:00
MHDA- 2019/09/10 06:00
CRDT- 2018/03/17 06:00
PHST- 2017/09/08 00:00 [received]
PHST- 2018/01/09 00:00 [accepted]
PHST- 2018/03/17 06:00 [pubmed]
PHST- 2019/09/10 06:00 [medline]
PHST- 2018/03/17 06:00 [entrez]
AID - 10.1038/s41395-018-0035-6 [doi]
PST - ppublish
SO  - Am J Gastroenterol. 2018 Jul;113(7):972-979. doi: 10.1038/s41395-018-0035-6. Epub 
      2018 Mar 15.