PMID- 29547614
OWN - NLM
STAT- MEDLINE
DCOM- 20190314
LR  - 20190314
IS  - 1538-067X (Electronic)
IS  - 1092-1095 (Linking)
VI  - 22
IP  - 2
DP  - 2018 Apr 1
TI  - Prevention of Stomatitis: Using Dexamethasone-Based Mouthwash to Inhibit 
      Everolimus-Related Stomatitis.
PG  - 211-217
LID - 10.1188/18.CJON.211-217 [doi]
AB  - BACKGROUND: A common class-specific toxicity of mammalian target of rapamycin 
      (mTOR) inhibitors is stomatitis. Some patients experience a severe form of mTOR 
      inhibitor-associated stomatitis (mIAS) that can have a negative effect on 
      nutritional status, compromise quality of life, and potentially lead to 
      nonadherence, reducing the efficacy of cancer therapy. OBJECTIVES: This article 
      aims to address an unmet need for education about mIAS among oncology nurses and 
      patients and to share findings about everolimus-related stomatitis from the SWISH 
      trial. METHODS: The authors reviewed the literature on mIAS and selected a case 
      series of experiences to illustrate successes and clinical challenges that an 
      oncology nurse might encounter when caring for patients with advanced breast 
      cancer who may develop everolimus-related stomatitis. FINDINGS: Recommendations 
      are provided for oncology nurses to educate patients on prevention, early 
      detection, monitoring, and management strategies to mitigate the incidence and 
      severity of everolimus-related stomatitis.
FAU - Saigal, Babita
AU  - Saigal B
AD  - University of Texas MD Anderson Cancer Center.
FAU - Guerra, Laura
AU  - Guerra L
AD  - Oncology Consultants, P.A.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Clin J Oncol Nurs
JT  - Clinical journal of oncology nursing
JID - 9705336
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Mouthwashes)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - 9HW64Q8G6G (Everolimus)
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Agents/adverse effects/therapeutic use
MH  - Breast Neoplasms/*drug therapy
MH  - Dexamethasone/*therapeutic use
MH  - Everolimus/*adverse effects/*therapeutic use
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Mouthwashes/*therapeutic use
MH  - Oncology Nursing/standards
MH  - Practice Guidelines as Topic
MH  - Stomatitis/*drug therapy/*prevention & control
MH  - Treatment Outcome
OTO - NOTNLM
OT  - breast cancer
OT  - corticosteroid
OT  - everolimus
OT  - mouthwash
OT  - prevention
OT  - stomatitis
EDAT- 2018/03/17 06:00
MHDA- 2019/03/15 06:00
CRDT- 2018/03/17 06:00
PHST- 2018/03/17 06:00 [entrez]
PHST- 2018/03/17 06:00 [pubmed]
PHST- 2019/03/15 06:00 [medline]
AID - 10.1188/18.CJON.211-217 [doi]
PST - ppublish
SO  - Clin J Oncol Nurs. 2018 Apr 1;22(2):211-217. doi: 10.1188/18.CJON.211-217.