PMID- 29551049
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1738-3684 (Print)
IS  - 1976-3026 (Electronic)
IS  - 1738-3684 (Linking)
VI  - 15
IP  - 4
DP  - 2018 Apr
TI  - Correlations of Four Genetic Single Nucleotide Polymorphisms in Brain-Derived 
      Neurotrophic Factor with Posttraumatic Stress Disorder.
PG  - 407-412
LID - 10.30773/pi.2017.06.17.1 [doi]
AB  - OBJECTIVE: To investigate the correlations of four genetic single nucleotide 
      polymorphisms (SNPs) of brain-derived neurotrophic factor (BDNF) with 
      posttraumatic stress disorder (PTSD). METHODS: A total of 300 patients with 
      sporadic PTSD and 150 healthy subjects (the control group) were selected 
      according to the diagnostic criteria of PTSD (DSM-IV), and the genotypes of the 
      BDNF SNPs G-712A, C270T, rs6265, and rs7103411 were detected by polymerase chain 
      reaction and direct DNA sequencing to determine intergroup differences in the 
      genotypes and allele frequencies; the p values were corrected with the 
      permutation test. RESULTS: The genotypes and allele frequencies of the SNPs 
      G-712A, rs6265, and rs7103411 of BDNF showed no significant intergroup 
      differences (p>0.05). However, the genotype and allele frequencies of C270T 
      showed significant differences between the PTSD group and the control group 
      (p<0.05). CONCLUSION: The SNP C270T of BDNF may be associated with PTSD. 
      Individuals carrying the polymorphic T allele of C270T may be more likely to 
      suffer from PTSD.
FAU - Guo, Jun-Cheng
AU  - Guo JC
AD  - Department of Science and Education, Hainan General Hospital, Hainan, China.
AD  - Department of Science and Education, Affiliated Hainan Hospital of Nanhua 
      University, Hainan, China.
FAU - Yang, Yi-Jun
AU  - Yang YJ
AD  - Hainan Province, Haikou People's Hospital, Hospital Dean's Office, Hainan, China.
FAU - Guo, Min
AU  - Guo M
AD  - The Psychological Research Center of Hainan General Hospital, Hainan, China.
FAU - Wang, Xiao-Dan
AU  - Wang XD
AD  - School of Public Health, Hainan Medical College, Hainan, China.
FAU - Juan, Yang
AU  - Juan Y
AD  - School of Public Health, Hainan Medical College, Hainan, China.
FAU - Gao, Yun-Suo
AU  - Gao YS
AD  - Department of Equipment, Hainan General Hospital, Hainan, China.
FAU - Fu, Lin-Qiu
AU  - Fu LQ
AD  - Department of Psychology, Hainan General Hospital, Hainan, China.
FAU - Jiang, Xiang-Ling
AU  - Jiang XL
AD  - Department of Clinical Laboratory, Hainan General Hospital, Hainan, China.
FAU - Fu, Lin-Mei
AU  - Fu LM
AD  - Medical Center, Hainan General Hospital, Hainan, China.
FAU - Huang, Tao
AU  - Huang T
AD  - Department of Clinical Laboratory, Hainan General Hospital, Hainan, China.
LA  - eng
PT  - Journal Article
DEP - 20180319
PL  - Korea (South)
TA  - Psychiatry Investig
JT  - Psychiatry investigation
JID - 101242994
PMC - PMC5912493
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Gene polymorphism
OT  - Posttraumatic stress disorder
EDAT- 2018/03/20 06:00
MHDA- 2018/03/20 06:01
PMCR- 2018/04/01
CRDT- 2018/03/20 06:00
PHST- 2016/11/23 00:00 [received]
PHST- 2017/06/10 00:00 [revised]
PHST- 2017/06/17 00:00 [accepted]
PHST- 2018/03/20 06:00 [pubmed]
PHST- 2018/03/20 06:01 [medline]
PHST- 2018/03/20 06:00 [entrez]
PHST- 2018/04/01 00:00 [pmc-release]
AID - pi.2017.06.17.1 [pii]
AID - pi-2017-06-17-1 [pii]
AID - 10.30773/pi.2017.06.17.1 [doi]
PST - ppublish
SO  - Psychiatry Investig. 2018 Apr;15(4):407-412. doi: 10.30773/pi.2017.06.17.1. Epub 
      2018 Mar 19.