PMID- 29551732 OWN - NLM STAT- MEDLINE DCOM- 20181113 LR - 20200930 IS - 1872-7549 (Electronic) IS - 0166-4328 (Linking) VI - 347 DP - 2018 Jul 16 TI - Physical exercise improves cognitive function by enhancing hippocampal neurogenesis and inhibiting apoptosis in male offspring born to obese mother. PG - 360-367 LID - S0166-4328(17)31508-5 [pii] LID - 10.1016/j.bbr.2018.03.018 [doi] AB - Maternal obesity induces hippocampal functional changes and leads to deficits in cognitive functions, such as learning and memory in offspring. We investigated the protective effects of physical exercise against cognitive function deficit in offspring born to obese mothers. Neurotrophic factors, neurogenesis, and apoptosis were analyzed in the hippocampus and dentate gyrus of offspring. Four-week-old female rats were fed a high-fat diet (HFD) for 20 weeks: 12 weeks prior to mating, and 8 weeks during pregnancy and breast-feeding. Male offspring rats were randomly divided into four groups: Control group (CON), exercise and control group (ECON), male offspring born to obese mother group (MOM), and exercise and MOM group (EMOM). In the exercise groups, treadmill exercise was performed 6 times per week for 4 weeks. Male offspring rats were subjected to the Morris water maze tests and step-down avoidance to assess spatial learning and memory, and short-term memory. The result showed that deficits in spatial learning and memory, and short-term memory in male offspring born to obese mothers was associated with decreases in brain-derived neurotrophic factor (BDNF) levels and neurogenesis, and an increase in apoptosis in the hippocampal dentate gyrus. Physical exercise improved spatial learning and memory, and short-term memory by enhancing BDNF levels and neurogenesis, and by inhibiting apoptosis in the hippocampal dentate gyrus of male offspring born to obese mothers. Our results suggest that physical exercise may be a preventive measure against or a treatment for cognitive function impairment. CI - Copyright (c) 2018 Elsevier B.V. All rights reserved. FAU - Kim, Tae-Woon AU - Kim TW AD - Department of Physiology, College of Medicine, KyungHee University, Seoul, Republic of Korea; Exercise Rehabilitation Research Institute, Department of Exercise & Health Science, SangMyung University, Seoul, Republic of Korea. FAU - Park, Hye-Sang AU - Park HS AD - Department of Physiology, College of Medicine, KyungHee University, Seoul, Republic of Korea. Electronic address: wini-phs@hanmail.net. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180315 PL - Netherlands TA - Behav Brain Res JT - Behavioural brain research JID - 8004872 RN - 0 (Brain-Derived Neurotrophic Factor) RN - EC 2.7.10.1 (Ntrk2 protein, rat) RN - EC 2.7.10.1 (Receptor, trkB) SB - IM MH - Animals MH - Apoptosis/physiology MH - Brain-Derived Neurotrophic Factor/metabolism MH - Cognition Disorders/*etiology/pathology/physiopathology/*therapy MH - Diet, High-Fat/adverse effects MH - Female MH - Hippocampus/pathology/*physiopathology MH - Lactation MH - Learning/physiology MH - Male MH - *Maternal Nutritional Physiological Phenomena MH - Memory/physiology MH - Neurogenesis/physiology MH - Neurons/pathology/physiology MH - Obesity/*physiopathology MH - Pregnancy MH - Random Allocation MH - Rats MH - Receptor, trkB/metabolism MH - Running/*physiology/psychology OTO - NOTNLM OT - Apoptosis OT - Cognitive function OT - Exercise OT - Maternal obesity OT - Neurogenesis OT - Offspring EDAT- 2018/03/20 06:00 MHDA- 2018/11/14 06:00 CRDT- 2018/03/20 06:00 PHST- 2017/09/08 00:00 [received] PHST- 2018/03/12 00:00 [revised] PHST- 2018/03/13 00:00 [accepted] PHST- 2018/03/20 06:00 [pubmed] PHST- 2018/11/14 06:00 [medline] PHST- 2018/03/20 06:00 [entrez] AID - S0166-4328(17)31508-5 [pii] AID - 10.1016/j.bbr.2018.03.018 [doi] PST - ppublish SO - Behav Brain Res. 2018 Jul 16;347:360-367. doi: 10.1016/j.bbr.2018.03.018. Epub 2018 Mar 15.