PMID- 29552187
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 15
IP  - 4
DP  - 2018 Apr
TI  - Expression of factors and key components associated with the PI3K signaling 
      pathway in colon cancer.
PG  - 5465-5472
LID - 10.3892/ol.2018.8044 [doi]
AB  - The pathophysiology of colorectal cancer (CRC) has not been fully elucidated. The 
      dysregulation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway 
      frequently contributes to the tumorigenesis and progression of human cancer. The 
      aim of the present study was to explore the expression and clinical significance 
      of a number of associated factors and key components of the PI3K signaling 
      pathway, including phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic 
      subunit alpha (p110alpha), phosphorylated protein kinase B (p-Akt) Ser473, p-mammalian 
      target of rapamycin (mTOR) Ser2448, cyclin D1, cyclin dependent kinase (CDK)4, 
      RELA proto-oncogene, nuclear factor-kappabeta subunit (p65), Ras and extracellular 
      signal-regulated kinase (ERK)1/2 in human CRC. The expression of target proteins 
      was detected using immunohistochemistry (IHC) in 65 CRC cases and 15 colonic 
      adenoma cases. The association between the expression of target proteins and 
      clinical pathological parameters was analyzed using a chi(2) test. IHC results 
      revealed that the expression of all target proteins was significantly increased 
      in CRC tissues compared with in colonic adenoma tissues (P<0.05). No significant 
      associations were observed between the expression of p110alpha, p-Akt Ser473, p-mTOR 
      Ser2448 and sex, age, differentiation, lymph node metastasis or 
      Tumor-Node-Metastasis staging (P>0.05). Cyclin D1, CDK4 and Ras were revealed to 
      be expressed significantly higher in poorly differentiated CRC compared with 
      moderately differentiated CRC (P<0.05). Expression of p65 and ERK1/2 were 
      significantly increased in cancer tissues with lymph node metastasis compared 
      with cancer tissues without lymph node metastasis (P<0.05). These results suggest 
      that the target proteins may all participate in the tumorigenesis of CRC. 
      Furthermore, cyclin D1, CDK4, Ras, p65 and ERK1/2 may be important in the 
      progression of CRC. The results of the present study may provide novel predictive 
      factors and therapeutic targets for CRC.
FAU - Chen, Hua
AU  - Chen H
AD  - Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, 
      Jinan, Shandong 250013, P.R. China.
FAU - Gao, Junyi
AU  - Gao J
AD  - Weifang Medical College, Weifang, Shandong 261031, P.R. China.
FAU - Du, Zhenhua
AU  - Du Z
AD  - Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, 
      Jinan, Shandong 250013, P.R. China.
FAU - Zhang, Xuequn
AU  - Zhang X
AD  - Graduate School, Taishan Medical University, Xintai, Shandong 271200, P.R. China.
FAU - Yang, Fei
AU  - Yang F
AD  - Department of Pathology, Jinan Central Hospital Affiliated to Shandong 
      University, Jinan, Shandong 250013, P.R. China.
FAU - Gao, Wei
AU  - Gao W
AD  - Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, 
      Jinan, Shandong 250013, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20180213
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC5840680
OTO - NOTNLM
OT  - colon cancer
OT  - immunohistochemistry
OT  - phosphoinositide 3-kinase signaling pathway
EDAT- 2018/03/20 06:00
MHDA- 2018/03/20 06:01
PMCR- 2018/02/13
CRDT- 2018/03/20 06:00
PHST- 2017/01/03 00:00 [received]
PHST- 2017/11/16 00:00 [accepted]
PHST- 2018/03/20 06:00 [entrez]
PHST- 2018/03/20 06:00 [pubmed]
PHST- 2018/03/20 06:01 [medline]
PHST- 2018/02/13 00:00 [pmc-release]
AID - OL-0-0-8044 [pii]
AID - 10.3892/ol.2018.8044 [doi]
PST - ppublish
SO  - Oncol Lett. 2018 Apr;15(4):5465-5472. doi: 10.3892/ol.2018.8044. Epub 2018 Feb 
      13.