PMID- 29552725
OWN - NLM
STAT- MEDLINE
DCOM- 20190708
LR  - 20190708
IS  - 1432-0878 (Electronic)
IS  - 0302-766X (Linking)
VI  - 373
IP  - 2
DP  - 2018 Aug
TI  - Age-dependent decrease in glomeruli and receptor cells containing alpha1-2 fucose 
      glycan in the mouse main olfactory system but not in the vomeronasal system.
PG  - 361-366
LID - 10.1007/s00441-018-2819-9 [doi]
AB  - Receptor cells of the olfactory epithelium (OE) and vomeronasal organ (VNO) 
      project axons to glomeruli in the main olfactory bulb (MOB) and accessory 
      olfactory bulb (AOB), respectively and undergo continuous turnover throughout 
      life. Alpha1-2 fucose (alpha1-2Fuc) glycan mediates neurite outgrowth and synaptic 
      plasticity and plays important roles in the formation of the olfactory system 
      during development. We previously confirmed the localization of alpha1-2Fuc glycan in 
      the olfactory system of 3- to 4-month-old mice but whether such localization 
      persists throughout life remains unknown. Here, the MOB, AOB, OE and VNO of 1-, 
      3- and 8-month-old mice were histochemically examined using Ulex europaeus 
      agglutinin-I (UEA-I) that specifically binds to alpha1-2Fuc glycan. Binding sites for 
      UEA-I in the MOB were similar among all age groups but the ratio of 
      UEA-I-positive glomeruli significantly decreased with aging. The frequency of 
      UEA-I-positive receptor cells in the OE of the two older groups was also 
      significantly lower than that of 1-month-old mice. On the other hand, UEA-I 
      binding in the AOB and VNO did not significantly differ among all three groups. 
      These findings suggest that the primary pathway of the main olfactory system 
      requires the role of alpha1-2Fuc glycan in young mice rather than old mice, while the 
      vomeronasal pathway equally requires this glycan in both young and old mice.
FAU - Kondoh, Daisuke
AU  - Kondoh D
AD  - Laboratory of Veterinary Anatomy, Obihiro University of Agriculture and 
      Veterinary Medicine, Nishi 2-11 Inada-cho, Obihiro, Hokkaido, 080-8555, Japan. 
      kondoh-d@obihiro.ac.jp.
FAU - Sasaki, Motoki
AU  - Sasaki M
AD  - Laboratory of Veterinary Anatomy, Obihiro University of Agriculture and 
      Veterinary Medicine, Nishi 2-11 Inada-cho, Obihiro, Hokkaido, 080-8555, Japan.
FAU - Kitamura, Nobuo
AU  - Kitamura N
AD  - Laboratory of Veterinary Anatomy, Obihiro University of Agriculture and 
      Veterinary Medicine, Nishi 2-11 Inada-cho, Obihiro, Hokkaido, 080-8555, Japan.
LA  - eng
GR  - Grant-in-Aid for Young Scientists (B) KAKENHI (15K/Ministry of Education, 
      Culture, Sports, Science and Technology/
PT  - Journal Article
DEP - 20180319
PL  - Germany
TA  - Cell Tissue Res
JT  - Cell and tissue research
JID - 0417625
RN  - 0 (Lectins)
RN  - 0 (Plant Lectins)
RN  - 0 (Ulex europaeus lectins)
RN  - 28RYY2IV3F (Fucose)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Fucose/*metabolism
MH  - Lectins/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Olfactory Bulb/*metabolism/ultrastructure
MH  - Olfactory Mucosa/*metabolism/ultrastructure
MH  - Plant Lectins/pharmacology
MH  - Statistics, Nonparametric
MH  - Vomeronasal Organ/*metabolism/ultrastructure
OTO - NOTNLM
OT  - Lectin histochemistry
OT  - Olfactory bulb
OT  - Olfactory epithelium
OT  - Postnatal change
OT  - Vomeronasal organ
EDAT- 2018/03/20 06:00
MHDA- 2019/07/10 06:00
CRDT- 2018/03/20 06:00
PHST- 2017/10/10 00:00 [received]
PHST- 2018/02/27 00:00 [accepted]
PHST- 2018/03/20 06:00 [pubmed]
PHST- 2019/07/10 06:00 [medline]
PHST- 2018/03/20 06:00 [entrez]
AID - 10.1007/s00441-018-2819-9 [pii]
AID - 10.1007/s00441-018-2819-9 [doi]
PST - ppublish
SO  - Cell Tissue Res. 2018 Aug;373(2):361-366. doi: 10.1007/s00441-018-2819-9. Epub 
      2018 Mar 19.