PMID- 29553868
OWN - NLM
STAT- MEDLINE
DCOM- 20190731
LR  - 20190731
IS  - 1551-5044 (Electronic)
IS  - 0022-1554 (Print)
IS  - 0022-1554 (Linking)
VI  - 66
IP  - 7
DP  - 2018 Jul
TI  - Association Between Fibroblast Growth Factor Receptor 1 Gene Amplification and 
      Human Papillomavirus Prevalence in Tonsillar Squamous Cell Carcinoma With 
      Clinicopathologic Analysis.
PG  - 511-522
LID - 10.1369/0022155418761652 [doi]
AB  - Amplification of fibroblast growth factor receptor 1 ( FGFR1) has been reported 
      in many squamous cell carcinomas, and human papillomavirus (HPV)-related 
      oropharyngeal squamous cell carcinoma has been characterized as a distinct subset 
      with favorable prognosis. Here, we investigated the FGFR1 amplification and HPV 
      status in tonsillar squamous cell carcinoma (TSCC) and analyzed the clinical 
      characteristics. HPV in situ hybridization (HPV ISH) and FGFR1 fluorescence in 
      situ hybridization (FISH) were performed using tissue microarray from 89 cases of 
      TSCC. Fourteen of 89 (15.7%) TSCC cases had FGFR1 amplification, and HPV was 
      detected in 59 of 89 (66.3%) cases. FGFR1 amplification status was not associated 
      with HPV positivity ( p=0.765). Outcomes were not significantly different between 
      FGFR1 amplified and non-amplified patients. Although FGFR1 amplified patients ( 
      n=4) in the HPV ISH-negative group ( n=30) had a tendency for poorer overall 
      survival, no statistical significance was identified ( p=0.150, log-rank). FGFR1 
      protein overexpression showed better disease-free survival ( p=0.031, log-rank) 
      in HPV-negative TSCC. This study suggests FGFR1 amplification may be important in 
      the pathogenesis of TSCC regardless of HPV status.
FAU - Park, Soonchan
AU  - Park S
AD  - Department of Radiology, Kyung Hee University Hospital at Gangdong, College of 
      Medicine, Kyung Hee University, Seoul, Republic of Korea.
FAU - Lee, Miji
AU  - Lee M
AD  - Department of Pathology, Veterans Health Service Medical Center, Seoul, Republic 
      of Korea.
FAU - Cho, Kyung-Ja
AU  - Cho KJ
AD  - Departments of Pathology, University of Ulsan College of Medicine, Asan Medical 
      Center, Seoul, Republic of Korea.
FAU - Kim, Sung Bae
AU  - Kim SB
AD  - Medical Oncology, University of Ulsan College of Medicine, Asan Medical Center, 
      Seoul, Republic of Korea.
FAU - Roh, Jong-Lyel
AU  - Roh JL
AD  - Head and Neck Surgery, University of Ulsan College of Medicine, Asan Medical 
      Center, Seoul, Republic of Korea.
FAU - Choi, Seung-Ho
AU  - Choi SH
AD  - Head and Neck Surgery, University of Ulsan College of Medicine, Asan Medical 
      Center, Seoul, Republic of Korea.
FAU - Nam, Soon Yuhl
AU  - Nam SY
AD  - Head and Neck Surgery, University of Ulsan College of Medicine, Asan Medical 
      Center, Seoul, Republic of Korea.
FAU - Kim, Sang Yoon
AU  - Kim SY
AD  - Head and Neck Surgery, University of Ulsan College of Medicine, Asan Medical 
      Center, Seoul, Republic of Korea.
FAU - Song, Joon Seon
AU  - Song JS
AD  - Departments of Pathology, University of Ulsan College of Medicine, Asan Medical 
      Center, Seoul, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180319
PL  - United States
TA  - J Histochem Cytochem
JT  - The journal of histochemistry and cytochemistry : official journal of the 
      Histochemistry Society
JID - 9815334
RN  - EC 2.7.10.1 (FGFR1 protein, human)
RN  - EC 2.7.10.1 (Receptor, Fibroblast Growth Factor, Type 1)
MH  - Adult
MH  - Carcinoma, Squamous Cell/*complications/*genetics/pathology/virology
MH  - Disease-Free Survival
MH  - Female
MH  - Gene Amplification
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Palatine Tonsil/metabolism/pathology/virology
MH  - Papillomaviridae/isolation & purification
MH  - Papillomavirus Infections/*complications/*genetics/pathology/virology
MH  - Prevalence
MH  - Receptor, Fibroblast Growth Factor, Type 1/*genetics
MH  - Tonsillar Neoplasms/*complications/*genetics/pathology/virology
PMC - PMC6055260
OTO - NOTNLM
OT  - fibroblast growth factor receptor 1
OT  - fluorescence in situ hybridization
OT  - human papillomavirus
OT  - squamous cell carcinoma
OT  - tonsil
COIS- Competing Interests: The author(s) declared no potential conflicts of interest 
      with respect to the research, authorship, and/or publication of this article.
EDAT- 2018/03/20 06:00
MHDA- 2019/08/01 06:00
PMCR- 2019/07/01
CRDT- 2018/03/20 06:00
PHST- 2018/03/20 06:00 [pubmed]
PHST- 2019/08/01 06:00 [medline]
PHST- 2018/03/20 06:00 [entrez]
PHST- 2019/07/01 00:00 [pmc-release]
AID - 10.1369_0022155418761652 [pii]
AID - 10.1369/0022155418761652 [doi]
PST - ppublish
SO  - J Histochem Cytochem. 2018 Jul;66(7):511-522. doi: 10.1369/0022155418761652. Epub 
      2018 Mar 19.