PMID- 29555202
OWN - NLM
STAT- MEDLINE
DCOM- 20180510
LR  - 20180621
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Linking)
VI  - 659
DP  - 2018 Jun 15
TI  - Association of vitamin D receptor gene polymorphisms with serum 25(OH)D levels 
      and metabolic syndrome in Thai population.
PG  - 59-66
LID - S0378-1119(18)30285-3 [pii]
LID - 10.1016/j.gene.2018.03.047 [doi]
AB  - Metabolic syndrome (MetS) increases the risk of developing cardiovascular disease 
      (CVD) and type 2 diabetes mellitus (T2DM). The vitamin D receptor gene (VDR) 
      polymorphisms have been found associated with MetS and serum 25(OH)D levels but 
      these associations remain controversial. The aim of this study was to investigate 
      the relationship between the VDR polymorphisms and MetS, metabolic components, 
      and serum 25(OH)D levels within the Thai population. A case-control study 
      included 237 participants with MetS according to the MetS diagnostic criteria of 
      NCEP ATPIII and 376 controls. Anthropometric data, blood pressure, lipid 
      profiles, serum 25 (OH)D, and fasting blood glucose were measured. VDR FokI, 
      BsmI, TaqI, and Cdx2 polymorphisms were genotyped by using PCR-HRM. There were no 
      significant differences in the frequencies of VDR genotypes and alleles between 
      MetS and the control groups. VDR TaqI TT, and BsmI BB + Bb genotypes were 
      associated with lower 25(OH)D levels (p < 0.05) in comparison to TaqI Tt, and 
      BsmI bb genotypes in the MetS group, respectively. In addition, the VDR Cdx2 GG 
      genotype was associated with higher WC compared with the AG genotype in all 
      subjects (p < 0.05). Logistic regression analysis revealed that BB + Bb genotypes 
      of the VDR BsmI had significantly increased the odds ratio (OR) of 
      hypertriglyceridemia when compared with the bb genotype (OR 1.87; 95% CI 
      1.10-3.19, p = 0.022). In conclusion, VDR BsmI variant was associated with 
      hypertriglyceridemia and may be predisposed to developing MetS. VDR TaqI and BsmI 
      polymorphisms seems to influence serum 25(OH)D levels in MetS subjects, while 
      Cdx2 polymorphism may influence WC in all subjects.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Sangkaew, Boonnisa
AU  - Sangkaew B
AD  - School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 
      Thailand.
FAU - Nuinoon, Manit
AU  - Nuinoon M
AD  - School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 
      Thailand; Research Excellence Center for Innovation and Health Products (RECIHP), 
      Walailak University, Nakhon Si Thammarat, Thailand.
FAU - Jeenduang, Nutjaree
AU  - Jeenduang N
AD  - School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 
      Thailand; Research Excellence Center for Innovation and Health Products (RECIHP), 
      Walailak University, Nakhon Si Thammarat, Thailand. Electronic address: 
      nutjaree.je@wu.ac.th.
LA  - eng
PT  - Journal Article
DEP - 20180316
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (Receptors, Calcitriol)
RN  - 0 (VDR protein, human)
RN  - P6YZ13C99Q (Calcifediol)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Calcifediol/*blood
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/blood/*genetics
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Receptors, Calcitriol/*genetics
MH  - Thailand
OTO - NOTNLM
OT  - Metabolic syndrome
OT  - Polymorphism
OT  - Serum 25(OH)D
OT  - VDR
EDAT- 2018/03/21 06:00
MHDA- 2018/05/11 06:00
CRDT- 2018/03/21 06:00
PHST- 2018/01/01 00:00 [received]
PHST- 2018/03/03 00:00 [revised]
PHST- 2018/03/15 00:00 [accepted]
PHST- 2018/03/21 06:00 [pubmed]
PHST- 2018/05/11 06:00 [medline]
PHST- 2018/03/21 06:00 [entrez]
AID - S0378-1119(18)30285-3 [pii]
AID - 10.1016/j.gene.2018.03.047 [doi]
PST - ppublish
SO  - Gene. 2018 Jun 15;659:59-66. doi: 10.1016/j.gene.2018.03.047. Epub 2018 Mar 16.