PMID- 29555354
OWN - NLM
STAT- MEDLINE
DCOM- 20190219
LR  - 20191210
IS  - 1872-6844 (Electronic)
IS  - 0920-1211 (Linking)
VI  - 142
DP  - 2018 May
TI  - Nonconvulsive status epilepticus after convulsive status epilepticus: Clinical 
      features, outcomes, and prognostic factors.
PG  - 53-57
LID - S0920-1211(17)30641-1 [pii]
LID - 10.1016/j.eplepsyres.2018.03.012 [doi]
AB  - OBJECTIVES: To investigate clinical characteristics and outcomes of nonconvulsive 
      status epilepticus (NCSE) after convulsive status epilepticus (CSE) and determine 
      risk factors for unfavorable outcomes. METHODS: We reviewed consecutive patients 
      with NCSE after CSE over eight years in the neurological intensive care unit. 
      Clinical presentations and the Salzburg EEG criteria for NCSE were used to 
      identify patients with NCSE after CSE. Demographics, clinical features, and 
      anti-epileptic treatment responses were collected and analyzed. Modified Rankin 
      Scale (mRS) was used to evaluate three-month outcomes. A multivariate logistic 
      regression model was used to determine independent prognostic factors. RESULTS: 
      Among 145 consecutive patients with convulsive SE, 48 (33.1%) patents eventually 
      evolved into NCSE. Two patients with cerebral anoxia were exclude. At three-month 
      follow-up, 23 patients (50.0%) had mRS >/= 3, and 16 (34.8%) died. Thirty-two 
      patients (69.6%) were given continuous intravenous anesthetic drugs (CIVADs). 
      Fourteen patients (30.4%) had CIVAD at the rate >50% proposed maximal dose (PMD). 
      There was a single predictor factor found significant after multivariate logistic 
      regression analysis: the recurrence of EEG seizures within two hours of 
      initiation of CIVAD at a dose of greater than half the proposed maximal dose (OR, 
      9.63; 95%CI, 1.08-86.18; p = 0.043). The use of CIVAD, even with a high dose 
      (>50% PMD), was not independently associated with unfavorable outcomes. 
      CONCLUSIONS: The recurrence of EEG seizures within two hours of initiation of 
      CIVAD at a dose of greater than half the proposed maximal dose predicts 
      unfavorable outcomes in NCSE after CSE. The refractoriness of the seizures might 
      be a significantly greater risk for poor outcome in NCSE after CSE than treatment 
      with CIVADs.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Yuan, Fang
AU  - Yuan F
AD  - Department of Neurology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, PR China.
FAU - Yang, Fang
AU  - Yang F
AD  - Department of Neurology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, PR China.
FAU - Li, Wen
AU  - Li W
AD  - Department of Neurology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, PR China.
FAU - Yang, Xiai
AU  - Yang X
AD  - Department of Neurology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, PR China.
FAU - Gao, Qiong
AU  - Gao Q
AD  - Department of Neurology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, PR China.
FAU - Bi, Lijie
AU  - Bi L
AD  - Department of Neurology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, PR China.
FAU - Jiang, Yongli
AU  - Jiang Y
AD  - Department of Neurology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, PR China.
FAU - Jiang, Wen
AU  - Jiang W
AD  - Department of Neurology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, PR China. Electronic address: jiangwen@fmmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180312
PL  - Netherlands
TA  - Epilepsy Res
JT  - Epilepsy research
JID - 8703089
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Critical Care/statistics & numerical data
MH  - Electroencephalography
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Outcome Assessment, Health Care
MH  - Prognosis
MH  - Retrospective Studies
MH  - Statistics, Nonparametric
MH  - *Status Epilepticus/diagnosis/physiopathology/therapy
MH  - *Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Anesthetic
OT  - Critical care
OT  - Nonconvulsive status epilepticus
OT  - Outcome
OT  - Refractory status epilepticus
EDAT- 2018/03/21 06:00
MHDA- 2019/03/21 06:00
CRDT- 2018/03/21 06:00
PHST- 2017/12/08 00:00 [received]
PHST- 2018/02/06 00:00 [revised]
PHST- 2018/03/11 00:00 [accepted]
PHST- 2018/03/21 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2018/03/21 06:00 [entrez]
AID - S0920-1211(17)30641-1 [pii]
AID - 10.1016/j.eplepsyres.2018.03.012 [doi]
PST - ppublish
SO  - Epilepsy Res. 2018 May;142:53-57. doi: 10.1016/j.eplepsyres.2018.03.012. Epub 
      2018 Mar 12.