PMID- 29556138
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240318
IS  - 1475-2867 (Print)
IS  - 1475-2867 (Electronic)
IS  - 1475-2867 (Linking)
VI  - 18
DP  - 2018
TI  - Prognostic role of long non-coding RNA XIST expression in patients with solid 
      tumors: a meta-analysis.
PG  - 34
LID - 10.1186/s12935-018-0535-x [doi]
LID - 34
AB  - BACKGROUND: The aberrant expression of long non-coding RNA (lncRNA) X 
      inactivate-specific transcript (XIST) has been demonstrated to be involved in the 
      tumourigenesis and the development of various cancers. Therefore, we conducted a 
      meta-analysis to assess the prognostic role of lncRNA XIST expression in solid 
      tumors. METHODS: The databases of PubMed, EMBase, Web of Science, Cochrane 
      library (up to Dec 31, 2017) were searched for the related studies and identified 
      15 eligible studies containing 1209 patients to include in the meta-analysis. 
      Hazards ratios (HRs) with corresponding 95% confidence intervals (CIs) were 
      pooled to estimate the association between lncRNA XIST expression and survival of 
      cancer patients from Asian. RESULTS: The result showed that higher lncRNA XIST 
      expression in cancer tissue was related to a worse overall survival (OS) 
      (HR = 1.54, 95% CI 1.07-2.23). In subgroup analysis, it revealed that lncRNA XIST 
      overexpression was significantly associated with worse OS in digestive system 
      tumors (HR = 1.67, 95% CI 1.11-2.51, p = 0.031). In addition, the association 
      between high lncRNA XIST expression and poor OS was also statistically 
      significant in other subgroups, including multivariate analysis (HR = 2.39, 95% 
      CI 1.28-4.46, p = 0.006, random-effect), patients' number was greater than 65 
      (HR = 1.75, 95% CI 1.24-2.47, p = 0.001, random-effect), and reported in text 
      (HR = 2.50, 95% CI 1.49-4.18, p = 0.000, random-effect). CONCLUSIONS: The 
      expression of lncRNA XIST could be regarded as a poor prognostic biomarker for 
      solid tumors, which might shed new light on epigenetic diagnostics and 
      therapeutics in tumors.
FAU - Mao, Huihui
AU  - Mao H
AD  - 1Comprehensive Laboratory, Changzhou Key Lab of Individualized Diagnosis and 
      Treatment Associated with High Technology Research, The Third Affiliated Hospital 
      of Soochow University, Changzhou, 213003 China. GRID: grid.452253.7
FAU - Wang, Kai
AU  - Wang K
AD  - 2Department of Urology, The Third Affiliated Hospital of Soochow University, 
      Changzhou, 213003 China. GRID: grid.452253.7
FAU - Feng, Yuehua
AU  - Feng Y
AD  - 1Comprehensive Laboratory, Changzhou Key Lab of Individualized Diagnosis and 
      Treatment Associated with High Technology Research, The Third Affiliated Hospital 
      of Soochow University, Changzhou, 213003 China. GRID: grid.452253.7
FAU - Zhang, Jun
AU  - Zhang J
AD  - 1Comprehensive Laboratory, Changzhou Key Lab of Individualized Diagnosis and 
      Treatment Associated with High Technology Research, The Third Affiliated Hospital 
      of Soochow University, Changzhou, 213003 China. GRID: grid.452253.7
FAU - Pan, Lili
AU  - Pan L
AD  - 1Comprehensive Laboratory, Changzhou Key Lab of Individualized Diagnosis and 
      Treatment Associated with High Technology Research, The Third Affiliated Hospital 
      of Soochow University, Changzhou, 213003 China. GRID: grid.452253.7
FAU - Zhan, Yuxia
AU  - Zhan Y
AD  - 1Comprehensive Laboratory, Changzhou Key Lab of Individualized Diagnosis and 
      Treatment Associated with High Technology Research, The Third Affiliated Hospital 
      of Soochow University, Changzhou, 213003 China. GRID: grid.452253.7
FAU - Sheng, Haijun
AU  - Sheng H
AD  - 1Comprehensive Laboratory, Changzhou Key Lab of Individualized Diagnosis and 
      Treatment Associated with High Technology Research, The Third Affiliated Hospital 
      of Soochow University, Changzhou, 213003 China. GRID: grid.452253.7
FAU - Luo, Guanghua
AU  - Luo G
AD  - 1Comprehensive Laboratory, Changzhou Key Lab of Individualized Diagnosis and 
      Treatment Associated with High Technology Research, The Third Affiliated Hospital 
      of Soochow University, Changzhou, 213003 China. GRID: grid.452253.7
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180309
PL  - England
TA  - Cancer Cell Int
JT  - Cancer cell international
JID - 101139795
PMC - PMC5845363
OTO - NOTNLM
OT  - Long non-coding RNA
OT  - Meta-analysis
OT  - Prognosis
OT  - XIST
EDAT- 2018/03/21 06:00
MHDA- 2018/03/21 06:01
PMCR- 2018/03/09
CRDT- 2018/03/21 06:00
PHST- 2018/01/15 00:00 [received]
PHST- 2018/03/06 00:00 [accepted]
PHST- 2018/03/21 06:00 [entrez]
PHST- 2018/03/21 06:00 [pubmed]
PHST- 2018/03/21 06:01 [medline]
PHST- 2018/03/09 00:00 [pmc-release]
AID - 535 [pii]
AID - 10.1186/s12935-018-0535-x [doi]
PST - epublish
SO  - Cancer Cell Int. 2018 Mar 9;18:34. doi: 10.1186/s12935-018-0535-x. eCollection 
      2018.