PMID- 29557099
OWN - NLM
STAT- MEDLINE
DCOM- 20190522
LR  - 20200225
IS  - 1833-3516 (Print)
IS  - 2209-1491 (Electronic)
IS  - 1833-3516 (Linking)
VI  - 48
IP  - 1
DP  - 2018 Mar 31
TI  - Hyperbaric oxygen treatment in thromboangiitis obliterans: a retrospective 
      clinical audit.
PG  - 31-35
LID - 10.28920/dhm48.1.31-35 [doi]
AB  - INTRODUCTION: Wounds refractory to standard treatment in patients with 
      thromboangiitis obliterans (TAO, Buerger's disease) are associated with 
      amputation, other morbidity and mortality. The purpose of this study was to 
      investigate the effect of hyperbaric oxygen treatment (HBOT) in patients with 
      TAO. MATERIALS AND METHODS: Ninety-seven patients with TAO with ischaemic wounds 
      treated between January 2007 and July 2016 were included in this dual-centre, 
      non-randomised, retrospective study. Patients receiving HBOT in addition to 
      conventional treatment were enrolled in an HBOT group (n = 47) and those 
      receiving conventional treatment alone in a non-HBOT group (n = 50). All patients 
      were Rutherford grade III at the time of enrolment. RESULTS: Significant 
      improvement in the major amputation rate was observed in the HBOT group 10 months 
      after starting treatment (2/47 vs. 13/50, P = 0.007). Numbers of patients 
      progressing to Rutherford grade I (27/47 vs. 17/50, P = 0.035), numbers of 
      patients healing completely (21 vs. 11, P = 0.031 and pain scores (visual 
      analogue scale; 1, range 0-8 vs. 6, range 0-9, P < 0.001) were also significantly 
      improved in the HBOT group. CONCLUSION: The addition of HBOT to conventional 
      treatment in TAO patients with non-healing ischaemic wounds and severe extremity 
      pain, conferred significant benefits in terms of wound healing and rest pain 
      control. Multi-centre, prospective, randomized studies with blinded outcome 
      analysis are now needed to elicit more reliable results.
CI  - Copyright: This article is the copyright of the authors who grant Diving and 
      Hyperbaric Medicine a non-exclusive licence to publish the article in electronic 
      and other forms.
FAU - Hemsinli, Dogus
AU  - Hemsinli D
AD  - Cardiovascular Surgery Department, Health Sciences University, Kanuni Research 
      and Training Hospital, Trabzon, Turkey.
AD  - Cardiovascular Surgery Department, Health Sciences University, Kanuni Research 
      and Training Hospital, Kasustu Mahallesi, Topal Osman Sokak, No:7, 61290 Yomra, 
      Trabzon, Turkey dogushem@hotmail.com.
FAU - Altun, Gokalp
AU  - Altun G
AD  - Cardiovascular Surgery Department, Karadeniz Technical University, Faculty of 
      Medicine, Trabzon.
FAU - Kaplan, Safiye Tuba
AU  - Kaplan ST
AD  - Internal Medicine Department, Health Sciences University, Kanuni Research and 
      Training Hospital, Trabzon.
FAU - Yildirim, Furkan
AU  - Yildirim F
AD  - Underwater and Hyperbaric Medicine Department, Health Sciences University, 
      Antalya Research and Training Hospital, Antalya, Turkey.
FAU - Cebi, Gamze
AU  - Cebi G
AD  - Underwater and Hyperbaric Medicine Department, Health Sciences University, Kanuni 
      Research and Training Hospital, Trabzon.
LA  - eng
PT  - Journal Article
DEP - 20180331
PL  - Australia
TA  - Diving Hyperb Med
JT  - Diving and hyperbaric medicine
JID - 101282742
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Clinical Audit
MH  - Female
MH  - Humans
MH  - *Hyperbaric Oxygenation/methods
MH  - Male
MH  - Middle Aged
MH  - Oxygen
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Thromboangiitis Obliterans/*therapy
MH  - *Wound Healing
PMC - PMC6467820
OTO - NOTNLM
OT  - Buerger's disease
OT  - Chronic wounds
OT  - Outcome
OT  - Pain
EDAT- 2018/03/21 06:00
MHDA- 2019/05/23 06:00
PMCR- 2019/03/31
CRDT- 2018/03/21 06:00
PHST- 2018/01/17 00:00 [received]
PHST- 2018/01/28 00:00 [accepted]
PHST- 2018/03/21 06:00 [entrez]
PHST- 2018/03/21 06:00 [pubmed]
PHST- 2019/05/23 06:00 [medline]
PHST- 2019/03/31 00:00 [pmc-release]
AID - 10.28920/dhm48.1.31-35 [doi]
PST - epublish
SO  - Diving Hyperb Med. 2018 Mar 31;48(1):31-35. doi: 10.28920/dhm48.1.31-35.