PMID- 29557362
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1673-5374 (Print)
IS  - 1876-7958 (Electronic)
IS  - 1673-5374 (Linking)
VI  - 13
IP  - 2
DP  - 2018 Feb
TI  - Contributions of neurotropic human herpesviruses herpes simplex virus 1 and human 
      herpesvirus 6 to neurodegenerative disease pathology.
PG  - 211-221
LID - 10.4103/1673-5374.226380 [doi]
AB  - Human herpesviruses (HVs) have developed ingenious mechanisms that enable them to 
      traverse the defenses of the central nervous system (CNS). The ability of HVs to 
      enter a state of latency, a defining characteristic of this viral family, allows 
      them to persist in the human host indefinitely. As such, HVs represent the most 
      frequently detected pathogens in the brain. Under constant immune pressure, these 
      infections are largely asymptomatic in healthy hosts. However, many neurotropic 
      HVs have been directly connected with CNS pathology in the context of other 
      stressors and genetic risk factors. In this review, we discuss the potential 
      mechanisms by which neurotropic HVs contribute to neurodegenerative disease (NDD) 
      pathology by highlighting two prominent members of the HV family, herpes simplex 
      virus 1 (HSV-1) and human herpesvirus 6 (HHV-6). We (i) introduce the infectious 
      pathways and replicative cycles of HSV-1 and HHV-6 and then (ii) review the 
      clinical evidence supporting associations between these viruses and the NDDs 
      Alzheimer's disease (AD) and multiple sclerosis (MS), respectively. We then (iii) 
      highlight and discuss potential mechanisms by which these viruses exert negative 
      effects on neurons and glia. Finally, we (iv) discuss how these viruses could 
      interact with other disease-modifying factors to contribute to the initiation 
      and/or progression of NDDs.
FAU - Hogestyn, Jessica M
AU  - Hogestyn JM
AD  - Department of Neuroscience, University of Rochester, Rochester, NY, USA.
FAU - Mock, David J
AU  - Mock DJ
AD  - Department of Biomedical Genetics, University of Rochester, Rochester, NY, USA.
FAU - Mayer-Proschel, Margot
AU  - Mayer-Proschel M
AD  - Department of Neuroscience, University of Rochester; Department of Biomedical 
      Genetics, University of Rochester, Rochester, NY, USA.
LA  - eng
GR  - R03 NS103124/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - India
TA  - Neural Regen Res
JT  - Neural regeneration research
JID - 101316351
PMC - PMC5879884
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - central nervous system
OT  - demyelination
OT  - herpes simplex virus 1
OT  - human herpesvirus 6
OT  - multiple sclerosis
OT  - neurodegeneration
OT  - viral latency
OT  - viral reactivation
COIS- None declared
EDAT- 2018/03/21 06:00
MHDA- 2018/03/21 06:01
PMCR- 2018/02/01
CRDT- 2018/03/21 06:00
PHST- 2018/03/21 06:00 [entrez]
PHST- 2018/03/21 06:00 [pubmed]
PHST- 2018/03/21 06:01 [medline]
PHST- 2018/02/01 00:00 [pmc-release]
AID - NeuralRegenRes_2018_13_2_211_226380 [pii]
AID - NRR-13-211 [pii]
AID - 10.4103/1673-5374.226380 [doi]
PST - ppublish
SO  - Neural Regen Res. 2018 Feb;13(2):211-221. doi: 10.4103/1673-5374.226380.