PMID- 29557672
OWN - NLM
STAT- MEDLINE
DCOM- 20191104
LR  - 20230307
IS  - 1944-9097 (Electronic)
IS  - 0362-028X (Linking)
VI  - 81
IP  - 4
DP  - 2018 Apr
TI  - Analysis of Chloramphenicol and Two Metabolites in Crab and Shrimp Following 
      Waterborne Exposure.
PG  - 677-683
LID - 10.4315/0362-028X.JFP-17-456 [doi]
AB  - The use of chloramphenicol (CAP) in aquaculture products is banned in many 
      countries, including the United States, due to human health issues. Very few 
      depletion and metabolism studies of CAP in seafood have been performed. Current 
      detection methods for CAP residues in food are directed toward the parent drug 
      molecule, but rapid elimination following treatment suggests the need for an 
      alternative marker residue. We identified, characterized, and determined the 
      persistence of two CAP metabolites, CAP-base (CAP-B) and CAP-alcohol (CAP-OH), in 
      crab and shrimp. Interday recoveries of CAP, CAP-B, and CAP-OH in muscle 
      fortified ( n = 9) at levels of 0.15 to 0.60 ng/g ranged from 95 to 127% and 101 
      to 119% for crab and shrimp, respectively, with repeatability ranging from 4 to 
      19%. The limit of detection for CAP and metabolites in crab and shrimp ranged 
      from 0.05 to 0.11 ng/g. We also monitored the depletion of CAP, CAP-B, and CAP-OH 
      in crab following waterborne exposures. To our knowledge, we present the first 
      CAP depletion and metabolite study following waterborne exposure in crabs, with 
      the aim of identifying alternative marker residues.
FAU - Jester, Edward L E
AU  - Jester ELE
AD  - 1 U.S. Food and Drug Administration, Division of Seafood Science and Technology, 
      Gulf Coast Seafood Laboratory, 1 Iberville Drive, Dauphin Island, Alabama 36528, 
      USA; and.
FAU - Loader, Jared I
AU  - Loader JI
AD  - 2 RJ Hill Laboratories Ltd., Private Bag 3205, Hamilton 3240, New Zealand.
FAU - Quintana, Harold A Flores
AU  - Quintana HAF
AD  - 1 U.S. Food and Drug Administration, Division of Seafood Science and Technology, 
      Gulf Coast Seafood Laboratory, 1 Iberville Drive, Dauphin Island, Alabama 36528, 
      USA; and.
FAU - Said, Kathleen R El
AU  - Said KRE
AD  - 1 U.S. Food and Drug Administration, Division of Seafood Science and Technology, 
      Gulf Coast Seafood Laboratory, 1 Iberville Drive, Dauphin Island, Alabama 36528, 
      USA; and.
FAU - Benner, Ronald A Jr
AU  - Benner RA Jr
AD  - 1 U.S. Food and Drug Administration, Division of Seafood Science and Technology, 
      Gulf Coast Seafood Laboratory, 1 Iberville Drive, Dauphin Island, Alabama 36528, 
      USA; and.
FAU - Abraham, Ann
AU  - Abraham A
AD  - 1 U.S. Food and Drug Administration, Division of Seafood Science and Technology, 
      Gulf Coast Seafood Laboratory, 1 Iberville Drive, Dauphin Island, Alabama 36528, 
      USA; and.
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Food Prot
JT  - Journal of food protection
JID - 7703944
RN  - 0 (Anti-Infective Agents)
RN  - 66974FR9Q1 (Chloramphenicol)
SB  - IM
MH  - Animals
MH  - Anti-Infective Agents/analysis
MH  - Aquaculture
MH  - *Brachyura/chemistry
MH  - *Chloramphenicol/analysis
MH  - Drug Residues/*analysis
MH  - Food Contamination/*analysis
MH  - *Palaemonidae/chemistry
MH  - Seafood
MH  - Shellfish/analysis
OTO - NOTNLM
OT  - Chloramphenicol
OT  - Crab
OT  - Metabolites
OT  - Persistence
OT  - Shrimp
EDAT- 2018/03/21 06:00
MHDA- 2019/11/05 06:00
CRDT- 2018/03/21 06:00
PHST- 2018/03/21 06:00 [pubmed]
PHST- 2019/11/05 06:00 [medline]
PHST- 2018/03/21 06:00 [entrez]
AID - S0362-028X(22)08511-8 [pii]
AID - 10.4315/0362-028X.JFP-17-456 [doi]
PST - ppublish
SO  - J Food Prot. 2018 Apr;81(4):677-683. doi: 10.4315/0362-028X.JFP-17-456.