PMID- 29557702
OWN - NLM
STAT- MEDLINE
DCOM- 20190430
LR  - 20190610
IS  - 1559-7016 (Electronic)
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 38
IP  - 6
DP  - 2018 Jun
TI  - Brain-derived neurotrophic factor secreted by the cerebral endothelium: A new 
      actor of brain function?
PG  - 935-949
LID - 10.1177/0271678X18766772 [doi]
AB  - Low cerebral levels of brain-derived neurotrophic factor (BDNF), which plays a 
      critical role in many brain functions, have been implicated in neurodegenerative, 
      neurological and psychiatric diseases. Thus, increasing BDNF levels in the brain 
      is considered an attractive possibility for the prevention/treatment of various 
      brain diseases. To date, BDNF-based therapies have largely focused on neurons. 
      However, given the cross-talk between endothelial cells and neurons and recent 
      evidence that BDNF expressed by the cerebral endothelium largely accounts for 
      BDNF levels present in the brain, it is likely that BDNF-based therapies would be 
      most effective if they also targeted the cerebral endothelium. In this review, we 
      summarize the available knowledge about the biology and actions of BDNF derived 
      from endothelial cells of the cerebral microvasculature and we emphasize the 
      remaining gaps and shortcomings.
FAU - Marie, Christine
AU  - Marie C
AD  - 1 INSERM U1093, Univ. Bourgogne Franche-Comte, Dijon, France.
FAU - Pedard, Martin
AU  - Pedard M
AD  - 1 INSERM U1093, Univ. Bourgogne Franche-Comte, Dijon, France.
AD  - 2 Service de Neurologie, CHRU, Dijon, France.
FAU - Quirie, Aurore
AU  - Quirie A
AD  - 1 INSERM U1093, Univ. Bourgogne Franche-Comte, Dijon, France.
FAU - Tessier, Anne
AU  - Tessier A
AD  - 1 INSERM U1093, Univ. Bourgogne Franche-Comte, Dijon, France.
FAU - Garnier, Philippe
AU  - Garnier P
AD  - 1 INSERM U1093, Univ. Bourgogne Franche-Comte, Dijon, France.
FAU - Totoson, Perle
AU  - Totoson P
AD  - 3 EA4267 PEPITE, FHU INCREASE, Univ. Bourgogne Franche-Comte, Besancon, France.
FAU - Demougeot, Celine
AU  - Demougeot C
AD  - 3 EA4267 PEPITE, FHU INCREASE, Univ. Bourgogne Franche-Comte, Besancon, France.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180320
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain/blood supply/*metabolism/pathology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Endothelial Cells/metabolism/pathology
MH  - Endothelium, Vascular/*metabolism/pathology
MH  - Humans
MH  - Mental Disorders/*metabolism/pathology
MH  - Neurodegenerative Diseases/*metabolism/pathology
MH  - Neurons/*metabolism/pathology
PMC - PMC5998997
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - cerebral endothelium
OT  - cognition
OT  - nitric oxide
OT  - tropomyosin-related kinase B
EDAT- 2018/03/21 06:00
MHDA- 2019/05/01 06:00
PMCR- 2019/06/01
CRDT- 2018/03/21 06:00
PHST- 2018/03/21 06:00 [pubmed]
PHST- 2019/05/01 06:00 [medline]
PHST- 2018/03/21 06:00 [entrez]
PHST- 2019/06/01 00:00 [pmc-release]
AID - 10.1177_0271678X18766772 [pii]
AID - 10.1177/0271678X18766772 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 2018 Jun;38(6):935-949. doi: 10.1177/0271678X18766772. 
      Epub 2018 Mar 20.