PMID- 29558209
OWN - NLM
STAT- MEDLINE
DCOM- 20181029
LR  - 20181029
IS  - 1715-5320 (Electronic)
IS  - 1715-5312 (Linking)
VI  - 43
IP  - 5
DP  - 2018 May
TI  - Electrically evoked local muscle contractions cause an increase in hippocampal 
      BDNF.
PG  - 491-496
LID - 10.1139/apnm-2017-0536 [doi]
AB  - High-intensity exercise has recently been shown to cause an increase in 
      brain-derived neurotropic factor (BDNF) in the hippocampus. Some studies have 
      suggested that myokines secreted from contracting skeletal muscle, such as irisin 
      (one of the truncated form of fibronectin type III domain-containing protein 5 
      (FNDC5)), play important roles in this process. Thus, we hypothesized that 
      locally evoked muscle contractions may cause an increase of BDNF in the 
      hippocampus through some afferent mechanisms. Under anesthesia, Sprague-Dawley 
      rats were fixed on a custom-made dynamometer and their triceps surae muscles were 
      made to maximally contract via delivery of electric stimulations of the sciatic 
      nerve (100 Hz with 1-ms pulse and 3-s duration). Following 50 repeated maximal 
      isometric contractions, the protein expressions of BDNF and activation of its 
      receptor in the hippocampus significantly increased compared with the 
      sham-operated control rats. However, the expression of both BDNF and FNDC5 within 
      stimulated muscles did not significantly increase, nor did their serum 
      concentrations change. These results indicate that local muscular contractions 
      under unconsciousness can induce BDNF expression in the hippocampus. This effect 
      may be mediated by peripheral reception of muscle contraction, but not by 
      systemic factors.
FAU - Maekawa, Takahiro
AU  - Maekawa T
AD  - a Department of Life Sciences, Graduate School of Arts and Sciences, The 
      University of Tokyo, Tokyo 153-8902, Japan.
FAU - Ogasawara, Riki
AU  - Ogasawara R
AD  - a Department of Life Sciences, Graduate School of Arts and Sciences, The 
      University of Tokyo, Tokyo 153-8902, Japan.
AD  - b Department of Life and Materials Engineering, Nagoya Institute of Technology, 
      Nagoya 466-8555, Japan.
FAU - Tsutaki, Arata
AU  - Tsutaki A
AD  - c Graduate School of Health and Sport Sciences, Nippon Sport Science University, 
      Tokyo 158-8508, Japan.
FAU - Lee, Kihyuk
AU  - Lee K
AD  - c Graduate School of Health and Sport Sciences, Nippon Sport Science University, 
      Tokyo 158-8508, Japan.
FAU - Nakada, Satoshi
AU  - Nakada S
AD  - a Department of Life Sciences, Graduate School of Arts and Sciences, The 
      University of Tokyo, Tokyo 153-8902, Japan.
FAU - Nakazato, Koichi
AU  - Nakazato K
AD  - c Graduate School of Health and Sport Sciences, Nippon Sport Science University, 
      Tokyo 158-8508, Japan.
FAU - Ishii, Naokata
AU  - Ishii N
AD  - a Department of Life Sciences, Graduate School of Arts and Sciences, The 
      University of Tokyo, Tokyo 153-8902, Japan.
LA  - eng
PT  - Journal Article
DEP - 20180320
PL  - Canada
TA  - Appl Physiol Nutr Metab
JT  - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition 
      et metabolisme
JID - 101264333
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (FNDC5 protein, rat)
RN  - 0 (Fibronectins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Electric Stimulation
MH  - Fibronectins/blood/genetics
MH  - Gene Expression Regulation
MH  - Hippocampus/*metabolism
MH  - *Isometric Contraction
MH  - Male
MH  - Muscle, Skeletal/physiology
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - afferent pathway
OT  - brain-derived neurotropic factor (BDNF)
OT  - contraction musculaire locale
OT  - domaine de fibronectine de type III (FNDC5)
OT  - facteur neutrophique derive du cerveau (BDNF)
OT  - fibronectin type III domain-containing protein 5(FNDC5)
OT  - hippocampe
OT  - hippocampus
OT  - local muscular contraction
OT  - muscles squelettiques
OT  - skeletal muscle
OT  - voie afferente
EDAT- 2018/03/21 06:00
MHDA- 2018/10/30 06:00
CRDT- 2018/03/21 06:00
PHST- 2018/03/21 06:00 [pubmed]
PHST- 2018/10/30 06:00 [medline]
PHST- 2018/03/21 06:00 [entrez]
AID - 10.1139/apnm-2017-0536 [doi]
PST - ppublish
SO  - Appl Physiol Nutr Metab. 2018 May;43(5):491-496. doi: 10.1139/apnm-2017-0536. 
      Epub 2018 Mar 20.