PMID- 29558315
OWN - NLM
STAT- MEDLINE
DCOM- 20190102
LR  - 20190102
IS  - 1096-4657 (Electronic)
IS  - 0361-073X (Linking)
VI  - 44
IP  - 3
DP  - 2018 May-Jun
TI  - Altered cardiovascular function is related to reduced BDNF in Parkinson's 
      disease.
PG  - 232-245
LID - 10.1080/0361073X.2018.1449589 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) has been linked to cardiovascular health 
      and function, however, the exact role is yet to be understood. The current study 
      examined the relationship of circulatory BDNF with vascular function in 
      Parkinson's disease (PD). ELISA was used to determine plasma BDNF in PD patients 
      and healthy control (CT). Additionally, forearm resting blood flow (RBf), 
      vascular resistance (RVr), venous capacitance (RVc), and venous outflow (RVo) as 
      well as post occlusion blood flow (OcBf), vascular resistance (OcVr), venous 
      capacitance (OcVc), and venous outflow (OcVo) were obtained using strain-gauge 
      plethysmography. Simple linear regression showed that being PD patient can 
      predict (p < 0.05) 12.9% of BDNF, 16.8% of RVc, 15.0% of OcVc, and 13.6% of OcVo. 
      Subsequent stepwise regression included BDNF, RVc, OcVc, and OcVo, showed that 
      being PD patient predicted (p < 0.05) 58.0% of BDNF, 47.7% of OcVo, and 15.1% of 
      OcVc. Another simple linear regression demonstrated that BDNF predicted 
      (p < 0.05) 18.5% of OcBf, 22.0% of OcVr, and 24.1% of OcVc in PD. In a subsequent 
      stepwise linear regression, BDNF explained 26% ofOcVr (p = 0.008) and 42% of OcVc 
      (p = 0.002) in PD. The study showed that BDNF is reduced and related to altered 
      vascular function in PD. The results suggest that BDNF might contribute to 
      preserving and maybe improving vascular function in PD.
FAU - Alomari, Mahmoud A
AU  - Alomari MA
AUID- ORCID: 0000-0003-3605-5946
AD  - a Division of Physical Therapy, Department of Rehabilitation Sciences , Jordan 
      University of Science and Technology , Irbid , Jordan.
FAU - Khalil, Hanan
AU  - Khalil H
AUID- ORCID: 0000-0001-7741-8892
AD  - b Department of Rehabilitation Sciences, Faculty of Applied Medical Sciences , 
      Jordan University of Science and Technology , Irbid , Jordan.
FAU - Khabour, Omar F
AU  - Khabour OF
AUID- ORCID: 0000-0002-3006-3104
AD  - c Department Medical Laboratory Science , Jordan University of Science and 
      Technology , Irbid , Jordan.
FAU - Alzoubi, Karem H
AU  - Alzoubi KH
AUID- ORCID: 0000-0002-2808-5099
AD  - d Department of Clinical Pharmacy , Jordan University of Science and Technology , 
      Irbid , Jordan.
FAU - Dersieh, Esraa H
AU  - Dersieh EH
AD  - e Department of Biological Sciences , Jordan University of Science and Technology 
      , Irbid , Jordan.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20180320
PL  - United States
TA  - Exp Aging Res
JT  - Experimental aging research
JID - 7603335
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aging
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Forearm/blood supply
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*blood/*physiopathology
MH  - Regional Blood Flow/physiology
MH  - Vascular Capacitance/physiology
MH  - Vascular Resistance/physiology
EDAT- 2018/03/21 06:00
MHDA- 2019/01/03 06:00
CRDT- 2018/03/21 06:00
PHST- 2018/03/21 06:00 [pubmed]
PHST- 2019/01/03 06:00 [medline]
PHST- 2018/03/21 06:00 [entrez]
AID - 10.1080/0361073X.2018.1449589 [doi]
PST - ppublish
SO  - Exp Aging Res. 2018 May-Jun;44(3):232-245. doi: 10.1080/0361073X.2018.1449589. 
      Epub 2018 Mar 20.