PMID- 29558533
OWN - NLM
STAT- MEDLINE
DCOM- 20180921
LR  - 20180921
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 59
IP  - 4
DP  - 2018 Mar 20
TI  - Local Progression Kinetics of Geographic Atrophy in Age-Related Macular 
      Degeneration Are Associated With Atrophy Border Morphology.
PG  - AMD12-AMD18
LID - 10.1167/iovs.17-23203 [doi]
AB  - PURPOSE: To assess the impact of distinct atrophy border characteristics based on 
      spectral-domain optical coherence tomography (SD-OCT) imaging on local atrophy 
      progression. METHODS: Patients with geographic atrophy (GA) secondary to AMD were 
      recruited in the context of the Longitudinal Fundus Autofluorescence in 
      Age-related Macular Degeneration and Directional Spread in Geographic Atrophy 
      studies (NCT00393692, NCT02051998). Horizontal and vertical SD-OCT scans were 
      acquired at sequential visits using a device allowing for anatomically accurate 
      registration of follow-up to baseline scans. For quantification of local atrophy 
      progression, the lateral spread of GA (LSGA) was measured. Further, border types 
      were independently graded. Comparison of LSGA between the different border types 
      was performed using linear mixed-effects models. RESULTS: Seventy-two eyes of 49 
      patients (27 female) aged 74.0 years (Inter quartile range [IQR], 68.1-79.0) were 
      included into this analysis. A total of 258 border sections were analyzed 
      longitudinally over a median period of 1.2 years (IQR, 0.9-1.6). At baseline, 
      17.1% borders were classified as 'regular', 47.7% as 'irregular', and 35.3% as 
      'splitting'. Sixty-two percent of the eyes exhibited more than one border type. 
      LSGA was slowest in 'regular' borders (62.85 +/- 25.29 mum/y), followed by 
      'irregular' borders (91.15 +/- 15.05 mum/y) and fastest in 'splitting' borders 
      (183.15 +/- 18.17 mum/y). Differences between the 'splitting' and each other border 
      type were statistically significant (P < 0.001). CONCLUSIONS: The results 
      indicate that SD-OCT-based assessment of local GA border morphology can serve as 
      a predictor for local atrophy progression. These observations help to better 
      understand the natural history and potential pathogenetic factors of GA 
      development and progression.
FAU - Lindner, Moritz
AU  - Lindner M
AD  - Department of Ophthalmology, University of Bonn, Bonn, Germany.
AD  - The Nuffield Laboratory of Ophthalmology, Sleep and Circadian Neuroscience 
      Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, 
      Oxford, United Kingdom.
AD  - Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, 
      United Kingdom.
FAU - Kosanetzky, Sebastian
AU  - Kosanetzky S
AD  - Department of Ophthalmology, University of Bonn, Bonn, Germany.
FAU - Pfau, Maximilian
AU  - Pfau M
AD  - Department of Ophthalmology, University of Bonn, Bonn, Germany.
FAU - Nadal, Jennifer
AU  - Nadal J
AD  - Institute for Medical Biometry, Informatics and Epidemiology, University Hospital 
      Bonn, Bonn, Germany.
FAU - Gordt, Lukas A
AU  - Gordt LA
AD  - Department of Ophthalmology, University of Bonn, Bonn, Germany.
FAU - Schmitz-Valckenberg, Steffen
AU  - Schmitz-Valckenberg S
AD  - Department of Ophthalmology, University of Bonn, Bonn, Germany.
FAU - Schmid, Matthias
AU  - Schmid M
AD  - Institute for Medical Biometry, Informatics and Epidemiology, University Hospital 
      Bonn, Bonn, Germany.
FAU - Holz, Frank G
AU  - Holz FG
AD  - Department of Ophthalmology, University of Bonn, Bonn, Germany.
FAU - Fleckenstein, Monika
AU  - Fleckenstein M
AD  - Department of Ophthalmology, University of Bonn, Bonn, Germany.
CN  - FAM-Study Group
LA  - eng
SI  - ClinicalTrials.gov/NCT00393692
SI  - ClinicalTrials.gov/NCT02051998
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Atrophy
MH  - Disease Progression
MH  - Female
MH  - Fluorescein Angiography
MH  - Follow-Up Studies
MH  - Geographic Atrophy/*diagnosis/etiology
MH  - Humans
MH  - Kinetics
MH  - Macular Degeneration/*complications
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retina/diagnostic imaging/*pathology
MH  - Retinal Pigment Epithelium/diagnostic imaging/*pathology
MH  - Tomography, Optical Coherence
EDAT- 2018/03/21 06:00
MHDA- 2018/09/22 06:00
CRDT- 2018/03/21 06:00
PHST- 2018/03/21 06:00 [entrez]
PHST- 2018/03/21 06:00 [pubmed]
PHST- 2018/09/22 06:00 [medline]
AID - 2675983 [pii]
AID - 10.1167/iovs.17-23203 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2018 Mar 20;59(4):AMD12-AMD18. doi: 
      10.1167/iovs.17-23203.