PMID- 29562669
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240109
IS  - 2079-4991 (Print)
IS  - 2079-4991 (Electronic)
IS  - 2079-4991 (Linking)
VI  - 8
IP  - 3
DP  - 2018 Mar 19
TI  - Synthesis of Gold Nanoparticles Using Leaf Extract of Ziziphus zizyphus and their 
      Antimicrobial Activity.
LID - 10.3390/nano8030174 [doi]
LID - 174
AB  - (1) Background: There is a growing need for the development of new methods for 
      the synthesis of nanoparticles. The interest in such particles has raised 
      concerns about the environmental safety of their production methods; (2) 
      Objectives: The current methods of nanoparticle production are often expensive 
      and employ chemicals that are potentially harmful to the environment, which calls 
      for the development of "greener" protocols. Herein we describe the synthesis of 
      gold nanoparticles (AuNPs) using plant extracts, which offers an alternative, 
      efficient, inexpensive, and environmentally friendly method to produce 
      well-defined geometries of nanoparticles; (3) Methods: The phytochemicals present 
      in the aqueous leaf extract acted as an effective reducing agent. The generated 
      AuNPs were characterized by Transmission electron microscopy (TEM), Scanning 
      electron microscope (SEM), and Atomic Force microscopy (AFM), X-ray diffraction 
      (XRD), UV-visible spectroscopy, energy dispersive X-ray (EDX), and 
      thermogravimetric analyses (TGA); (4) Results and Conclusions: The prepared 
      nanoparticles were found to be biocompatible and exhibited no antimicrobial or 
      antifungal effect, deeming the particles safe for various applications in 
      nanomedicine. TGA analysis revealed that biomolecules, which were present in the 
      plant extract, capped the nanoparticles and acted as stabilizing agents.
FAU - Aljabali, Alaa A A
AU  - Aljabali AAA
AUID- ORCID: 0000-0002-9519-6338
AD  - Faculty of Pharmacy, Yarmouk University, P.O.BOX 566, Irbid 21163, Jordan. 
      alaaj@yu.edu.jo.
FAU - Akkam, Yazan
AU  - Akkam Y
AD  - Faculty of Pharmacy, Yarmouk University, P.O.BOX 566, Irbid 21163, Jordan. 
      yazan.a@yu.edu.jo.
FAU - Al Zoubi, Mazhar Salim
AU  - Al Zoubi MS
AUID- ORCID: 0000-0003-0248-4777
AD  - Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, 
      Irbid 21163, Jordan. mszoubi@yu.edu.jo.
FAU - Al-Batayneh, Khalid M
AU  - Al-Batayneh KM
AD  - Department of Biological Science, Yarmouk University, P.O.BOX 566, Irbid 21163, 
      Jordan. albatynehk@yu.edu.jo.
FAU - Al-Trad, Bahaa
AU  - Al-Trad B
AUID- ORCID: 0000-0002-2062-6241
AD  - Department of Biological Science, Yarmouk University, P.O.BOX 566, Irbid 21163, 
      Jordan. bahaa.tr@yu.edu.jo.
FAU - Abo Alrob, Osama
AU  - Abo Alrob O
AD  - Faculty of Pharmacy, Yarmouk University, P.O.BOX 566, Irbid 21163, Jordan. 
      osama.yousef@yu.edu.jo.
FAU - Alkilany, Alaaldin M
AU  - Alkilany AM
AD  - School of Pharmacy, University of Jordan, Aljubeiha, Amman, Jordan 11942, Jordan. 
      a.alkilany@ju.edu.jo.
FAU - Benamara, Mourad
AU  - Benamara M
AD  - Institute for Nanoscience, University of Arkansas, Fayetteville, AR 72701, USA. 
      mourad@uark.edu.
FAU - Evans, David J
AU  - Evans DJ
AUID- ORCID: 0000-0002-6290-2849
AD  - John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK. 
      Dave.Evans@jic.ac.uk.
LA  - eng
PT  - Journal Article
DEP - 20180319
PL  - Switzerland
TA  - Nanomaterials (Basel)
JT  - Nanomaterials (Basel, Switzerland)
JID - 101610216
PMC - PMC5869665
OTO - NOTNLM
OT  - Ziziphus zizyphus
OT  - antifungal activity
OT  - biopharmaceutics
OT  - biosynthesis
OT  - gold nanoparticles
OT  - green chemistry
OT  - nanomaterials
COIS- The authors declare no conflict of interest.
EDAT- 2018/03/23 06:00
MHDA- 2018/03/23 06:01
PMCR- 2018/03/19
CRDT- 2018/03/23 06:00
PHST- 2018/03/01 00:00 [received]
PHST- 2018/03/14 00:00 [revised]
PHST- 2018/03/15 00:00 [accepted]
PHST- 2018/03/23 06:00 [entrez]
PHST- 2018/03/23 06:00 [pubmed]
PHST- 2018/03/23 06:01 [medline]
PHST- 2018/03/19 00:00 [pmc-release]
AID - nano8030174 [pii]
AID - nanomaterials-08-00174 [pii]
AID - 10.3390/nano8030174 [doi]
PST - epublish
SO  - Nanomaterials (Basel). 2018 Mar 19;8(3):174. doi: 10.3390/nano8030174.