PMID- 29562767
OWN - NLM
STAT- MEDLINE
DCOM- 20200518
LR  - 20200518
IS  - 1947-6043 (Electronic)
IS  - 1947-6035 (Print)
IS  - 1947-6035 (Linking)
VI  - 10
IP  - 4
DP  - 2019 Oct
TI  - Synovial Fluid Eotaxin-1 Levels May Reflect Disease Progression in Primary Knee 
      Osteoarthritis Among Elderly Han Chinese: A Cross-Sectional Study.
PG  - 408-416
LID - 10.1177/1947603518764280 [doi]
AB  - OBJECTIVE: The CC chemokine family member eotaxin-1, also named chemokine C-C 
      motif ligand 11 (CCL11), has been detected in knee osteoarthritis (OA) and could 
      induce breakdown of cartilage matrix. This study was performed to investigate the 
      plasma and synovial fluid eotaxin-1 levels with the disease progression in 
      elderly Han Chinese with primary knee OA. DESIGN: A total of 143 elderly primary 
      knee OA patients and 135 healthy controls were enrolled in the study. The Western 
      Ontario and McMaster Universities Arthritis Index (WOMAC) was performed to 
      evaluate the clinical severity. The radiographic severity was assessed by 
      Kellgren-Lawrence (K-L) grading. Plasma and synovial fluid (SF) eotaxin-1 levels 
      were explored using enzyme-linked immunosorbent assay. The SF levels of matrix 
      metalloproteinase-3 (MMP-3) and interleukin-6 (IL-6) were also examined. RESULTS: 
      Elevated plasma eotaxin-1 levels were found in knee OA patients compared with 
      healthy controls. Eotaxin-1 levels in SF of knee OA patients with K-L grade 4 
      were significantly elevated compared with those with K-L grades 2 and 3. 
      Meanwhile, knee OA patients with K-L grade 3 had significantly increased SF 
      levels of eotaxin-1 compared with those with K-L grade 2. Plasma eotaxin-1 levels 
      in different K-L grading did not reach significant difference. Eotaxin-1 levels 
      in SF of knee OA patients were significantly associated with disease severity 
      evaluated by KL grading criteria. In addition, eotaxin-1 levels in SF were 
      positively related to clinical severity illustrated by WOMAC as well as 
      biochemical markers MMP-3 and IL-6. CONCLUSIONS: Eotaxin-1 levels in SF instead 
      of plasma, were independently and positively related to the disease severity in 
      elderly knee OA patients. The inhibition of eotaxin-1 and its related signaling 
      pathways may serve as a novel therapeutic approach for OA progression.
FAU - Li, Bei
AU  - Li B
AD  - School of Public Health, Southern Medical University, Guangzhou, China.
AD  - School of Health Services Management, Southern Medical University, Guangzhou, 
      China.
FAU - Zhang, Yi-Li
AU  - Zhang YL
AD  - School of Public Health, Southern Medical University, Guangzhou, China.
AD  - School of Health Services Management, Southern Medical University, Guangzhou, 
      China.
FAU - Yu, Shou-Yi
AU  - Yu SY
AD  - School of Public Health, Southern Medical University, Guangzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180322
PL  - United States
TA  - Cartilage
JT  - Cartilage
JID - 101518378
RN  - 0 (Biomarkers)
RN  - 0 (CCL11 protein, human)
RN  - 0 (Chemokine CCL11)
SB  - IM
MH  - Aged
MH  - Biomarkers/metabolism
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Chemokine CCL11/*metabolism
MH  - Cross-Sectional Studies
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Osteoarthritis, Knee/*diagnosis/immunology
MH  - Radiography
MH  - Severity of Illness Index
MH  - Synovial Fluid/*immunology
PMC - PMC6755868
OTO - NOTNLM
OT  - disease progression
OT  - elderly knee osteoarthritis
OT  - eotaxin-1
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2018/03/23 06:00
MHDA- 2020/05/19 06:00
PMCR- 2020/04/01
CRDT- 2018/03/23 06:00
PHST- 2018/03/23 06:00 [pubmed]
PHST- 2020/05/19 06:00 [medline]
PHST- 2018/03/23 06:00 [entrez]
PHST- 2020/04/01 00:00 [pmc-release]
AID - 10.1177_1947603518764280 [pii]
AID - 10.1177/1947603518764280 [doi]
PST - ppublish
SO  - Cartilage. 2019 Oct;10(4):408-416. doi: 10.1177/1947603518764280. Epub 2018 Mar 
      22.