PMID- 29563613
OWN - NLM
STAT- MEDLINE
DCOM- 20190913
LR  - 20190913
IS  - 2042-0226 (Electronic)
IS  - 1672-7681 (Print)
IS  - 1672-7681 (Linking)
VI  - 15
IP  - 4
DP  - 2018 Apr
TI  - Chemokine and chemotactic signals in dendritic cell migration.
PG  - 346-352
LID - 10.1038/s41423-018-0005-3 [doi]
AB  - Dendritic cells (DCs) are professional antigen-presenting cells responsible for 
      the activation of specific T-cell responses and for the development of immune 
      tolerance. Immature DCs reside in peripheral tissues and specialize in antigen 
      capture, whereas mature DCs reside mostly in the secondary lymphoid organs where 
      they act as antigen-presenting cells. The correct localization of DCs is strictly 
      regulated by a large variety of chemotactic and nonchemotactic signals that 
      include bacterial products, DAMPs (danger-associated molecular patterns), 
      complement proteins, lipids, and chemokines. These signals function both 
      individually and in concert, generating a complex regulatory network. This 
      network is regulated at multiple levels through different strategies, such as 
      synergistic interactions, proteolytic processing, and the actions of atypical 
      chemokine receptors. Understanding this complex scenario will help to clarify the 
      role of DCs in different pathological conditions, such as autoimmune diseases and 
      cancers and will uncover new molecular targets for therapeutic interventions.
FAU - Tiberio, Laura
AU  - Tiberio L
AUID- ORCID: 0000-0003-0482-9898
AD  - Department of Molecular and Translational Medicine, University of Brescia, 
      Brescia, Italy.
FAU - Del Prete, Annalisa
AU  - Del Prete A
AD  - Department of Molecular and Translational Medicine, University of Brescia, 
      Brescia, Italy.
AD  - Humanitas Clinical and Research Institute, Rozzano-Milano, Italy.
FAU - Schioppa, Tiziana
AU  - Schioppa T
AD  - Department of Molecular and Translational Medicine, University of Brescia, 
      Brescia, Italy.
AD  - Humanitas Clinical and Research Institute, Rozzano-Milano, Italy.
FAU - Sozio, Francesca
AU  - Sozio F
AD  - Department of Molecular and Translational Medicine, University of Brescia, 
      Brescia, Italy.
AD  - Humanitas Clinical and Research Institute, Rozzano-Milano, Italy.
FAU - Bosisio, Daniela
AU  - Bosisio D
AD  - Department of Molecular and Translational Medicine, University of Brescia, 
      Brescia, Italy.
FAU - Sozzani, Silvano
AU  - Sozzani S
AUID- ORCID: 0000-0002-3144-8743
AD  - Department of Molecular and Translational Medicine, University of Brescia, 
      Brescia, Italy. silvano.sozzani@unibs.it.
AD  - Humanitas Clinical and Research Institute, Rozzano-Milano, Italy. 
      silvano.sozzani@unibs.it.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180321
PL  - China
TA  - Cell Mol Immunol
JT  - Cellular & molecular immunology
JID - 101242872
RN  - 0 (Chemokines)
RN  - 0 (Receptors, Chemokine)
SB  - IM
MH  - Animals
MH  - *Cell Movement
MH  - Chemokines/*metabolism
MH  - *Chemotaxis
MH  - Dendritic Cells/*cytology/metabolism
MH  - Humans
MH  - Receptors, Chemokine/metabolism
MH  - Signal Transduction
PMC - PMC6052805
COIS- The authors declare no competing interests.
EDAT- 2018/03/23 06:00
MHDA- 2019/09/14 06:00
PMCR- 2019/04/01
CRDT- 2018/03/23 06:00
PHST- 2017/08/03 00:00 [received]
PHST- 2018/01/11 00:00 [accepted]
PHST- 2018/01/10 00:00 [revised]
PHST- 2018/03/23 06:00 [pubmed]
PHST- 2019/09/14 06:00 [medline]
PHST- 2018/03/23 06:00 [entrez]
PHST- 2019/04/01 00:00 [pmc-release]
AID - 10.1038/s41423-018-0005-3 [pii]
AID - 5 [pii]
AID - 10.1038/s41423-018-0005-3 [doi]
PST - ppublish
SO  - Cell Mol Immunol. 2018 Apr;15(4):346-352. doi: 10.1038/s41423-018-0005-3. Epub 
      2018 Mar 21.