PMID- 29563869
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 10
DP  - 2018
TI  - Altered Brain Functional Hubs and Connectivity in Type 2 Diabetes Mellitus 
      Patients: A Resting-State fMRI Study.
PG  - 55
LID - 10.3389/fnagi.2018.00055 [doi]
LID - 55
AB  - Type 2 diabetes mellitus (T2DM) affects a vast population and is closely 
      associated with cognitive impairment. However, the mechanisms of cognitive 
      impairment in T2DM patients have not been unraveled. Research on the basic units 
      (nodes or hubs and edges) of the brain functional network on the basis of 
      neuroimaging may advance our understanding of the network change pattern in T2DM 
      patients. This study investigated the change patterns of brain functional hubs 
      using degree centrality (DC) analysis and the connectivity among these hubs using 
      functional connectivity and Granger causality analysis. Compared to healthy 
      controls, the DC values were higher in the left anterior cingulate gyrus (ACG) 
      and lower in the bilateral lateral occipital cortices (LOC) and right precentral 
      gyrus (PreCG) in T2DM patients. The functional connectivity between the left ACG 
      and the right PreCG was stronger in T2DM patients, whereas the functional 
      connectivity among the right PreCG and bilateral LOC was weaker. A negative 
      causal effect from the left ACG to left LOC and a positive effect from the left 
      ACG to right LOC were observed in T2DM patients, while in healthy controls, the 
      opposite occurred. Additionally, the reserve of normal brain function in T2DM 
      patients was negatively associated with the elevated glycemic parameters. This 
      study demonstrates that there are brain functional hubs and connectivity 
      alterations that may reflect the aberrant information communication in the brain 
      of T2DM patients. The findings may advance our understanding of the mechanisms of 
      T2DM-related cognitive impairment.
FAU - Liu, Daihong
AU  - Liu D
AD  - Department of Radiology, Southwest Hospital, Third Military Medical University 
      (Army Medical University), Chongqing, China.
FAU - Duan, Shanshan
AU  - Duan S
AD  - Department of Endocrinology, The Third Affiliation Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Zhou, Chaoyang
AU  - Zhou C
AD  - Department of Radiology, Southwest Hospital, Third Military Medical University 
      (Army Medical University), Chongqing, China.
FAU - Wei, Ping
AU  - Wei P
AD  - Department of Endocrinology, Southwest Hospital, Third Military Medical 
      University (Army Medical University), Chongqing, China.
FAU - Chen, Lihua
AU  - Chen L
AD  - Department of Radiology, Southwest Hospital, Third Military Medical University 
      (Army Medical University), Chongqing, China.
FAU - Yin, Xuntao
AU  - Yin X
AD  - Department of Radiology, Southwest Hospital, Third Military Medical University 
      (Army Medical University), Chongqing, China.
FAU - Zhang, Jiuquan
AU  - Zhang J
AD  - Department of Radiology, Southwest Hospital, Third Military Medical University 
      (Army Medical University), Chongqing, China.
FAU - Wang, Jian
AU  - Wang J
AD  - Department of Radiology, Southwest Hospital, Third Military Medical University 
      (Army Medical University), Chongqing, China.
LA  - eng
PT  - Journal Article
DEP - 20180306
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC5845755
OTO - NOTNLM
OT  - Granger causality analysis
OT  - cognitive impairment
OT  - degree centrality
OT  - functional connectivity
OT  - resting-state functional MRI
OT  - type 2 diabetes mellitus
EDAT- 2018/03/23 06:00
MHDA- 2018/03/23 06:01
PMCR- 2018/01/01
CRDT- 2018/03/23 06:00
PHST- 2017/06/19 00:00 [received]
PHST- 2018/02/19 00:00 [accepted]
PHST- 2018/03/23 06:00 [entrez]
PHST- 2018/03/23 06:00 [pubmed]
PHST- 2018/03/23 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2018.00055 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2018 Mar 6;10:55. doi: 10.3389/fnagi.2018.00055. 
      eCollection 2018.