PMID- 29564064
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 2008-2258 (Print)
IS  - 2008-4234 (Electronic)
IS  - 2008-2258 (Linking)
VI  - 11
IP  - 1
DP  - 2018 Winter
TI  - Genetic association between a single nucleotide polymorphism in Interleukin-16 
      (rs4072111) and susceptibility to chronic HCV infection in an Iranian population.
PG  - 42-47
AB  - AIM: Our goal was to identify the putative association of rs4072111 variant in 
      IL-16 gene and HCV susceptibility in an Iranian population. BACKGROUND: 
      Interleukin 16 (IL-16), a multifunctional cytokine, plays a vital role in 
      modulation of immune system. METHODS: In present case control and cross sectional 
      study, IL-16 gene variant in 300 patients with hepatitis C (HCV) infection and 
      300 healthy individuals were analyzed. To evaluate this possible association, 
      genomic DNA from venous blood was extracted and genotypes of IL-16 rs4072111 
      variant were determined by polymerase chain reaction- Fragments Length 
      Polymorphism Technique (PCR-RFLP). Then, rs4072111 C/T genotypes frequency and 
      allelic distribution were evaluated in each group. RESULTS: The results of 
      genotyping showed 82% CC, 17.3% CT, 0.7% TT in the control group and 78% CC, 20% 
      CT and 2% TT in the case group. The distribution of rs4072111 C allele was 90.7% 
      in controls and 88% in case group respectively.However, no correlation between 
      IL-16 rs4072111 C/T variants and susceptibility to chronic HCV infection was 
      found in the present study. CONCLUSION: We concluded the rs4072111 C/T cannot be 
      considered as a proper biomarker to identify susceptibility to chronic hepatitis 
      C virus infection.
FAU - Karkhane, Maryam
AU  - Karkhane M
AD  - Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, 
      Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti 
      University of Medical Sciences, Tehran, Iran.
FAU - Mohebbi, Seyed Reza
AU  - Mohebbi SR
AD  - Gastroenterology and Liver Diseases Research Center, Research Institute for 
      Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
FAU - Azimzadeh, Pedram
AU  - Azimzadeh P
AD  - Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, 
      Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti 
      University of Medical Sciences, Tehran, Iran.
FAU - Avarandeh, Hasti
AU  - Avarandeh H
AD  - Foodborne and waterborne diseases research center, Research institute for 
      gastroenterology and liver diseases, Shahid Beheshti University of Medical 
      Sciences.
FAU - Kazemian, Shabnam
AU  - Kazemian S
AD  - Gastroenterology and Liver Diseases Research Center, Research Institute for 
      Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
FAU - Sharifian, Afsaneh
AU  - Sharifian A
AD  - Gastroenterology and Liver Diseases Research Center, Research Institute for 
      Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
FAU - Hatami, Behzad
AU  - Hatami B
AD  - Gastroenterology and Liver Diseases Research Center, Research Institute for 
      Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
FAU - Asadzadeh Aghdaei, Hamid
AU  - Asadzadeh Aghdaei H
AD  - Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, 
      Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti 
      University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Gastroenterol Hepatol Bed Bench
JT  - Gastroenterology and hepatology from bed to bench
JID - 101525875
PMC - PMC5849117
OTO - NOTNLM
OT  - profile
EDAT- 2018/03/23 06:00
MHDA- 2018/03/23 06:01
PMCR- 2018/01/01
CRDT- 2018/03/23 06:00
PHST- 2018/03/23 06:00 [entrez]
PHST- 2018/03/23 06:00 [pubmed]
PHST- 2018/03/23 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - GHFBB-11-042 [pii]
PST - ppublish
SO  - Gastroenterol Hepatol Bed Bench. 2018 Winter;11(1):42-47.