PMID- 29564917
OWN - NLM
STAT- MEDLINE
DCOM- 20190708
LR  - 20190708
IS  - 1744-4160 (Electronic)
IS  - 1381-3455 (Linking)
VI  - 125
IP  - 3
DP  - 2019 Jul
TI  - Interactive effects of apelin, renin-angiotensin system and nitric oxide in 
      treatment of obesity-induced type 2 diabetes mellitus in male albino rats.
PG  - 244-254
LID - 10.1080/13813455.2018.1453521 [doi]
AB  - Apelin and its receptor (APJ) are involved in the regulation of a variety of 
      pathophysiological processes. We studied the effect of apelin treatment on 
      obesity-induced type 2 diabetes mellitus (T2DM) and possible interaction between 
      apelin/APJ system and renin-angiotensin system (RAS). Forty eight male albino 
      rats were divided into two groups: control group and diabetic group. Diabetic 
      group was subdivided into: control diabetic, apelin-treated, 
      apelin + losartan-treated, apelin + l-NAME-treated and losartan-treated diabetic 
      subgroup. Administration of apelin-13 yielded an improvement of IR, 
      dyslipidaemia, inflammation, oxidative stress with significant decrease in AT1R 
      gene expression and significant increase in ACE2 gene expression in adipose 
      tissues. Losartan + apelin yielded a further significant decrease in ATR1 gene 
      expression, glycaemic indices, serum TGs and TPA versus Apelin only. Adding 
      l-NAME in subgroup (2D) reversed the effect of apelin. We suggested that the 
      beneficial effect of Apelin is mainly mediated by NO-activated pathway and/or 
      ACE2/Ang (1-7) dependent pathway.
FAU - Sabry, Maha Mohamed
AU  - Sabry MM
AD  - a Physiology Department, Faculty of Medicine , Cairo University , Cairo , Egypt.
FAU - Mahmoud, Manal Moustafa
AU  - Mahmoud MM
AD  - a Physiology Department, Faculty of Medicine , Cairo University , Cairo , Egypt.
FAU - Shoukry, Heba Samy
AU  - Shoukry HS
AD  - a Physiology Department, Faculty of Medicine , Cairo University , Cairo , Egypt.
FAU - Rashed, Laila
AU  - Rashed L
AD  - b Biochemistry Department, Faculty of Medicine , Cairo University , Cairo , 
      Egypt.
FAU - Kamar, Samaa Samir
AU  - Kamar SS
AD  - c Medical Histology Department, Faculty of Medicine , Cairo University , Cairo , 
      Egypt.
FAU - Ahmed, Mona Mohamed
AU  - Ahmed MM
AD  - a Physiology Department, Faculty of Medicine , Cairo University , Cairo , Egypt.
LA  - eng
PT  - Journal Article
DEP - 20180322
PL  - England
TA  - Arch Physiol Biochem
JT  - Archives of physiology and biochemistry
JID - 9510153
RN  - 0 (Angiotensin II Type 1 Receptor Blockers)
RN  - 0 (Apelin)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Insulin)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - JMS50MPO89 (Losartan)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
SB  - IM
MH  - Angiotensin II Type 1 Receptor Blockers/administration & dosage
MH  - Animals
MH  - Apelin/*administration & dosage
MH  - Biomarkers/*analysis
MH  - Blood Glucose/analysis
MH  - Diabetes Mellitus, Experimental/etiology/metabolism/pathology/*prevention & 
      control
MH  - Diabetes Mellitus, Type 2/etiology/metabolism/pathology/*prevention & control
MH  - Diet, High-Fat/adverse effects
MH  - Drug Therapy, Combination
MH  - Enzyme Inhibitors/administration & dosage
MH  - Insulin/metabolism
MH  - Insulin Resistance
MH  - Losartan/administration & dosage
MH  - Male
MH  - NG-Nitroarginine Methyl Ester/administration & dosage
MH  - Nitric Oxide/*metabolism
MH  - Obesity/*complications/etiology/pathology
MH  - Rats
MH  - Renin-Angiotensin System/*drug effects
OTO - NOTNLM
OT  - Type 2 diabetes mellitus (T2DM)
OT  - apelin
OT  - endothelial nitric oxide synthase (eNOS)
OT  - renin-angiotensin system (RAS)
EDAT- 2018/03/23 06:00
MHDA- 2019/07/10 06:00
CRDT- 2018/03/23 06:00
PHST- 2018/03/23 06:00 [pubmed]
PHST- 2019/07/10 06:00 [medline]
PHST- 2018/03/23 06:00 [entrez]
AID - 10.1080/13813455.2018.1453521 [doi]
PST - ppublish
SO  - Arch Physiol Biochem. 2019 Jul;125(3):244-254. doi: 
      10.1080/13813455.2018.1453521. Epub 2018 Mar 22.