PMID- 29566095
OWN - NLM
STAT- MEDLINE
DCOM- 20180727
LR  - 20181114
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 3
DP  - 2018
TI  - Metabolic recovery from heavy exertion following banana compared to sugar 
      beverage or water only ingestion: A randomized, crossover trial.
PG  - e0194843
LID - 10.1371/journal.pone.0194843 [doi]
LID - e0194843
AB  - OBJECTIVES AND METHODS: Using a randomized, crossover, counterbalanced approach, 
      cyclists (N = 20, overnight fasted state) engaged in the four 75-km time trials 
      (2-week washout) while ingesting two types of bananas with similar carbohydrate 
      (CHO) but different phenolic content (Cavendish, CAV; mini-yellow, MIY, 63% 
      higher polyphenols), a 6% sugar beverage (SUG), and water only (WAT). CHO intake 
      was set at 0.2 g/kg every 15 minutes. Blood samples were collected pre-exercise 
      and 0 h-, 0.75 h-,1.5 h-, 3 h-, 4.5 h-, 21 h-, 45 h-post-exercise. RESULTS: Each 
      of the CHO trials (CAV, MIY, SUG) compared to water was associated with higher 
      post-exercise plasma glucose and fructose, and lower leukocyte counts, plasma 
      9+13 HODES, and IL-6, IL-10, and IL-1ra. OPLS-DA analysis showed that metabolic 
      perturbation (N = 1,605 metabolites) for WAT (86.8+/-4.0 arbitrary units) was 
      significantly greater and sustained than for CAV (70.4+/-3.9, P = 0.006), MIY 
      (68.3+/-4.0, P = 0.002), and SUG (68.1+/-4.2, P = 0.002). VIP ranking (<3.0, N = 25 
      metabolites) showed that both CAV and MIY were associated with significant fold 
      changes in metabolites including those from amino acid and xenobiotics pathways. 
      OPLS-DA analysis of immediate post-exercise metabolite shifts showed a 
      significant separation of CAV and MIY from both WAT and SUG (R2Y = 0.848, Q2Y = 
      0.409). COX-2 mRNA expression was lower in both CAV and MIY, but not SUG, versus 
      WAT at 21-h post-exercise in THP-1 monocytes cultured in plasma samples. Analysis 
      of immediate post-exercise samples showed a decrease in LPS-stimulated THP-1 
      monocyte extracellular acidification rate (ECAR) in CAV and MIY, but not SUG, 
      compared to WAT. CONCLUSIONS: CHO ingestion from bananas or a sugar beverage had 
      a comparable influence in attenuating metabolic perturbation and inflammation 
      following 75-km cycling. Ex-vivo analysis with THP-1 monocytes supported a 
      decrease in COX-2 mRNA expression and reduced reliance on glycolysis for ATP 
      production following ingestion of bananas but not sugar water when compared to 
      water alone. TRIAL REGISTRATION: ClinicalTrials.gov, U.S. National Institutes of 
      Health, identifier: NCT02994628.
FAU - Nieman, David C
AU  - Nieman DC
AUID- ORCID: 0000-0002-8305-1860
AD  - Human Performance Laboratory, Appalachian State University, North Carolina 
      Research Campus, Kannapolis, North Carolina, United States of America.
FAU - Gillitt, Nicholas D
AU  - Gillitt ND
AD  - Dole Nutrition Research Laboratory, North Carolina Research Campus, Kannapolis, 
      North Carolina, United States of America.
FAU - Sha, Wei
AU  - Sha W
AD  - Bioinformatics Services Division, University of North Carolina at Charlotte, 
      North Carolina Research Campus, Kannapolis, North Carolina, United States of 
      America.
FAU - Esposito, Debora
AU  - Esposito D
AD  - Plants for Human Health Institute, North Carolina State University, North 
      Carolina Research Campus, Kannapolis, North Carolina, United States of America.
FAU - Ramamoorthy, Sivapriya
AU  - Ramamoorthy S
AD  - Metabolon, Inc., Durham, North Carolina, United States of America.
LA  - eng
SI  - ClinicalTrials.gov/NCT02994628
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20180322
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Dietary Carbohydrates)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Adult
MH  - *Beverages
MH  - *Bicycling/physiology
MH  - Cross-Over Studies
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Drinking Behavior/physiology
MH  - Eating/physiology
MH  - Exercise/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Musa
MH  - Physical Exertion/drug effects/*physiology
MH  - *Recovery of Function/drug effects
MH  - *Water/administration & dosage
MH  - Young Adult
PMC - PMC5864065
COIS- Competing Interests: We have the following interests. This study was funded by 
      Dole Foods. Dr. Nicholas Gillitt works as a scientist in the Dole Nutrition 
      Research Laboratory, and Sivapriya Ramamoorthy is employed by Metabolon, Inc. 
      There are no patents, products in development or marketed products to declare. 
      This does not alter our adherence to all the PLOS ONE policies on sharing data 
      and materials, as detailed online in the guide for authors.
EDAT- 2018/03/23 06:00
MHDA- 2018/07/28 06:00
PMCR- 2018/03/22
CRDT- 2018/03/23 06:00
PHST- 2018/01/08 00:00 [received]
PHST- 2018/02/21 00:00 [accepted]
PHST- 2018/03/23 06:00 [entrez]
PHST- 2018/03/23 06:00 [pubmed]
PHST- 2018/07/28 06:00 [medline]
PHST- 2018/03/22 00:00 [pmc-release]
AID - PONE-D-17-43865 [pii]
AID - 10.1371/journal.pone.0194843 [doi]
PST - epublish
SO  - PLoS One. 2018 Mar 22;13(3):e0194843. doi: 10.1371/journal.pone.0194843. 
      eCollection 2018.