PMID- 29566248
OWN - NLM
STAT- MEDLINE
DCOM- 20190404
LR  - 20190404
IS  - 1460-2709 (Electronic)
IS  - 1369-3786 (Linking)
VI  - 57
IP  - 3
DP  - 2019 Apr 1
TI  - Prevalence of sensitization to Aspergillus flavus in patients with allergic 
      bronchopulmonary aspergillosis.
PG  - 270-276
LID - 10.1093/mmy/myy012 [doi]
AB  - Aspergillus fumigatus is the most common Aspergillus species worldwide; however, 
      A. flavus has also been shown to be prevalent in North India. Herein, we 
      investigate the prevalence of sensitization to A. flavus in subjects with 
      allergic bronchopulmonary aspergillosis (ABPA). We also evaluate the occurrence 
      of allergic bronchopulmonary mycosis (ABPM) due to A. flavus. Treatment-naive 
      subjects with ABPA underwent sputum culture; and, skin testing, fungal-specific 
      immunoglobulin E (IgE) and serum precipitation tests for A. fumigatus and A. 
      flavus. Sensitization to A. flavus was diagnosed if any immunological test for A. 
      flavus was positive in subjects with ABPA. ABPM was labelled as probable if 
      sputum cultures grew A. flavus and A. flavus-specific IgE was greater than A. 
      fumigatus-specific IgE; and, possible if only A. flavus-specific IgE was greater 
      than A. fumigatus-specific IgE. Fifty-three subjects with a mean (SD) age of 34.2 
      (12.8) years were included. Sensitization to A. flavus was seen in 51 (96.2%) 
      subjects, with overlap occurring in 49 (92.5%), 21 (39.6%), and 12 (22.6%) 
      instances on fungal-specific IgE, skin prick test and precipitins, respectively. 
      Sputum culture was positive in 18 (33.9%; A. flavus [n = 12], A. fumigatus [n = 
      6]) subjects. ABPM due to A. flavus was diagnosed in 16 (30.2%) subjects (10 
      probable, 6 possible). They were more likely to have high-attenuation mucus and a 
      trend towards higher occurrence of sinusitis, compared to ABPA. We found a high 
      occurrence of sensitization to A. flavus in subjects with ABPA. Subjects with A. 
      flavus-related ABPM had a higher likelihood of high-attenuation mucus and 
      probability of sinusitis. More studies are required to confirm this observation.
CI  - (c) The Author(s) 2018. Published by Oxford University Press on behalf of The 
      International Society for Human and Animal Mycology.
FAU - Sehgal, Inderpaul Singh
AU  - Sehgal IS
AD  - Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and 
      Research (PGIMER), Chandigarh, India.
FAU - Choudhary, Hansraj
AU  - Choudhary H
AD  - Department of Medical Microbiology, Postgraduate Institute of Medical Education 
      and Research (PGIMER), Chandigarh, India.
FAU - Dhooria, Sahajal
AU  - Dhooria S
AD  - Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and 
      Research (PGIMER), Chandigarh, India.
FAU - Aggarwal, Ashutosh Nath
AU  - Aggarwal AN
AD  - Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and 
      Research (PGIMER), Chandigarh, India.
FAU - Bansal, Sandeep
AU  - Bansal S
AD  - Department of Otorhinolaryngology, Postgraduate Institute of Medical Education 
      and Research (PGIMER), Chandigarh, India.
FAU - Garg, Mandeep
AU  - Garg M
AD  - Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical 
      Education and Research (PGIMER), Chandigarh, India.
FAU - Behera, Digambar
AU  - Behera D
AD  - Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and 
      Research (PGIMER), Chandigarh, India.
FAU - Chakrabarti, Arunaloke
AU  - Chakrabarti A
AD  - Department of Medical Microbiology, Postgraduate Institute of Medical Education 
      and Research (PGIMER), Chandigarh, India.
FAU - Agarwal, Ritesh
AU  - Agarwal R
AD  - Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and 
      Research (PGIMER), Chandigarh, India.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - England
TA  - Med Mycol
JT  - Medical mycology
JID - 9815835
RN  - 0 (Antibodies, Fungal)
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Antibodies, Fungal/*blood
MH  - Aspergillosis, Allergic Bronchopulmonary/diagnosis/*epidemiology/*immunology
MH  - Aspergillus flavus/*immunology
MH  - Aspergillus fumigatus/immunology
MH  - Asthma/diagnosis/epidemiology/immunology
MH  - Female
MH  - Humans
MH  - Hypersensitivity/epidemiology/*microbiology
MH  - Immunoglobulin E/blood
MH  - Immunoglobulin G/blood
MH  - India/epidemiology
MH  - Invasive Pulmonary Aspergillosis/*epidemiology/immunology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Prospective Studies
MH  - Skin Tests
OTO - NOTNLM
OT  - Aspergillus
OT  - ABPA
OT  - ABPM
OT  - asthma
OT  - cystic fibrosis
OT  - fungal sensitization
EDAT- 2018/03/23 06:00
MHDA- 2019/04/05 06:00
CRDT- 2018/03/23 06:00
PHST- 2017/11/22 00:00 [received]
PHST- 2018/01/14 00:00 [revised]
PHST- 2018/02/07 00:00 [accepted]
PHST- 2018/03/23 06:00 [pubmed]
PHST- 2019/04/05 06:00 [medline]
PHST- 2018/03/23 06:00 [entrez]
AID - 4941977 [pii]
AID - 10.1093/mmy/myy012 [doi]
PST - ppublish
SO  - Med Mycol. 2019 Apr 1;57(3):270-276. doi: 10.1093/mmy/myy012.