PMID- 29566610
OWN - NLM
STAT- MEDLINE
DCOM- 20181015
LR  - 20181015
IS  - 1544-2217 (Electronic)
IS  - 0300-9858 (Linking)
VI  - 55
IP  - 4
DP  - 2018 Jul
TI  - Histologic Changes Associated With Placental Separation in Gilts Infected with 
      Porcine Reproductive and Respiratory Syndrome Virus.
PG  - 521-530
LID - 10.1177/0300985818765067 [doi]
AB  - The placenta is a vital organ providing the developing fetus with nutrient and 
      gas exchange, thermoregulation, and waste elimination necessary for fetal 
      development, as well as producing hormones to maintain pregnancy. It is 
      hypothesized that fetal pig death in porcine reproductive and respiratory 
      syndrome may be attributed to pathology of the maternal-fetal interface leading 
      to premature placental separation. This study was designed to evaluate the 
      chronologic progression of porcine reproductive and respiratory syndrome virus 
      (PRRSV)-induced lesions at the maternal-fetal interface, with particular focus on 
      placental separation in experimentally challenged third-trimester gilts. Fifteen 
      gilts were inoculated with a virulent strain of PRRSV-2 on gestation day 86 +/- 
      0.4. On multiple days postinoculation, 3 gilts along with 1 sham-inoculated 
      control per time point were euthanized, and uterine and fetal placental tissues 
      corresponding to each fetus were collected for histopathologic evaluation. The 
      presence of any fetal lesion was 23 times more likely in compromised 
      (meconium-stained and decomposed) compared with viable fetuses ( P < .001). In 
      PRRSV-infected gilts, endometritis was more severe than placentitis, and the 
      severity of endometrial inflammation and vasculitis increased progressively from 
      2 to 14 days postinoculation. Neither placental vasculitis nor a chronologic 
      progression in the severity of placental detachment was observed. Severe 
      placental detachment was more frequently present in PRRSV-infected compared with 
      noninfected samples and was most significantly associated with placental 
      inflammation, compared with other uterine lesions, viral load, or termination 
      day. The results of this study suggest that placental separation by itself is not 
      sufficient to significantly compromise fetal viability in reproductive porcine 
      reproductive and respiratory syndrome.
FAU - Novakovic, Predrag
AU  - Novakovic P
AD  - 1 Department of Large Animal Clinical Sciences, Western College of Veterinary 
      Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
FAU - Detmer, Susan E
AU  - Detmer SE
AD  - 2 Department of Veterinary Pathology, Western College of Veterinary Medicine, 
      University of Saskatchewan, Saskatoon, SK, Canada.
FAU - Suleman, Muhammad
AU  - Suleman M
AD  - 1 Department of Large Animal Clinical Sciences, Western College of Veterinary 
      Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
FAU - Malgarin, Carol M
AU  - Malgarin CM
AD  - 1 Department of Large Animal Clinical Sciences, Western College of Veterinary 
      Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
FAU - MacPhee, Daniel J
AU  - MacPhee DJ
AD  - 3 Department of Veterinary Biomedical Sciences, Western College of Veterinary 
      Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
FAU - Harding, John C S
AU  - Harding JCS
AD  - 1 Department of Large Animal Clinical Sciences, Western College of Veterinary 
      Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180322
PL  - United States
TA  - Vet Pathol
JT  - Veterinary pathology
JID - 0312020
SB  - IM
MH  - Animals
MH  - Endometritis/pathology/*veterinary/virology
MH  - Endometrium/pathology/virology
MH  - Female
MH  - Fetus/pathology/virology
MH  - Placenta/pathology/virology
MH  - Porcine Reproductive and Respiratory Syndrome/*pathology/virology
MH  - Porcine respiratory and reproductive syndrome virus/*physiology
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/pathology/*veterinary/virology
MH  - Swine
MH  - Vasculitis/pathology/*veterinary/virology
MH  - Viral Load/veterinary
OTO - NOTNLM
OT  - detachment
OT  - endometritis
OT  - fetal death
OT  - pigs
OT  - placenta
OT  - placental separation
OT  - porcine reproductive and respiratory syndrome
OT  - vasculitis
EDAT- 2018/03/24 06:00
MHDA- 2018/10/16 06:00
CRDT- 2018/03/24 06:00
PHST- 2018/03/24 06:00 [pubmed]
PHST- 2018/10/16 06:00 [medline]
PHST- 2018/03/24 06:00 [entrez]
AID - 10.1177/0300985818765067 [doi]
PST - ppublish
SO  - Vet Pathol. 2018 Jul;55(4):521-530. doi: 10.1177/0300985818765067. Epub 2018 Mar 
      22.